INT172500

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Context Info
Confidence 0.01
First Reported 2002
Last Reported 2002
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.00
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Ednra) plasma membrane (Ednra) signal transducer activity (Ednra)
Ednra (Rattus norvegicus)
Coc (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 94 100.00 Very High Very High Very High
Dopamine 30 99.28 Very High Very High Very High
Pain 4 97.92 Very High Very High Very High
nMDA receptor 16 95.80 Very High Very High Very High
withdrawal 4 92.40 High High
anticonvulsant 6 85.68 High High
Glutamate 6 81.56 Quite High
gABA 10 79.36 Quite High
antagonist 4 78.08 Quite High
agonist 4 58.72 Quite High
Disease Link Frequency Relevance Heat
Pain 4 97.92 Very High Very High Very High
Substance Withdrawal Syndrome 4 92.76 High High
Convulsion 102 91.84 High High
Toxicity 6 88.80 High High
Depression 14 88.44 High High
Stress 66 73.88 Quite High
Shock 2 38.80 Quite Low
Attention Deficit Hyperactivity Disorder 2 11.44 Low Low
Body Weight 6 5.00 Very Low Very Low Very Low
Drowning 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, EtOH enhanced COC-induced euphoric effects and attenuated subjective pain, and is actually the most frequently coabused drug with COC [15,16].
EtOH Positive_regulation (enhanced) of COC associated with pain and cocaine
1) Confidence 0.01 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC137594 Disease Relevance 0.83 Pain Relevance 0.65
In particular, with respect to combined COC-EtOH treatments, the euphoric effects of COC [34] have been reported to be enhanced by EtOH, possibly due to DA receptor-mediated endocrinal changes, the synthesis of the euphoric metabolite cocaethylene, etc [34,39].
EtOH Spec (possibly) Positive_regulation (enhanced) of COC associated with dopamine and cocaine
2) Confidence 0.01 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC137594 Disease Relevance 0.17 Pain Relevance 0.55

General Comments

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