INT172513

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Context Info
Confidence 0.02
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.24
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 1
ECT (Homo sapiens)
Mir343 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 44 99.16 Very High Very High Very High
Antinociceptive 31 82.00 Quite High
antinociception 44 77.00 Quite High
intrathecal 35 65.28 Quite High
epidural 2 64.80 Quite High
agonist 32 44.80 Quite Low
tail-flick 9 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Acute pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Paralysis 9 61.08 Quite High
Heart Rate Under Development 1 59.24 Quite High
Sleep Disorders 2 58.24 Quite High
Death 2 57.84 Quite High
Nociception 13 50.00 Quite Low
Targeted Disruption 4 49.68 Quite Low
Pain 3 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus it is possible if McN-A-343 is not totally selective for the M1 subtype, that the ECT effects of McN-A-343 at the level of the spinal cord are mediated by M3 receptors.
ECT Negative_regulation (effects) of McN-A-343 in spinal cord associated with spinal cord
1) Confidence 0.02 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC137595 Disease Relevance 0.24 Pain Relevance 0.47

General Comments

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