INT172518

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 6.01
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
MCF7 1
brain 1
platelet 1
fibroblasts 1
Gill 1


Pain Term Frequency Confidence Heat
cytokine 17 69.68 Quite High
palliative 7 67.68 Quite High
Inflammation 40 50.00 Quite Low
member 8 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Adhesions 44 99.20 Very High Very High Very High
Cancer 344 99.16 Very High Very High Very High
Inflammatory Breast Neoplasms 114 98.76 Very High Very High Very High
Breast Cancer 62 96.80 Very High Very High Very High
Glioma 4 95.44 Very High Very High Very High
Head & Neck Cancer 22 95.20 Very High Very High Very High
Colon Cancer 45 94.08 High High
Metastasis 61 89.36 High High
Pathologic Processes 1 87.24 High High
Death 12 86.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of the ER and PgR genes, c-myb, c-erb2, c-myc, c-fos, the epidermal growth factor receptor (EGFR) gene, and pS2 (a small secreted protein isolated from MCF7 cells after induction by 17?
Gene_expression (Expression) of epidermal growth factor receptor in MCF7
1) Confidence 0.75 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.98 Pain Relevance 0
The same result was obtained for the epidermal growth factor receptor (EGFR), which contains a total of 25 ectodomain disulfide bonds, and is expressed at substantial levels on A431 cells (Gill and Lazar, 1981) (Figure 4B).
Gene_expression (expressed) of epidermal growth factor receptor in Gill
2) Confidence 0.75 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0 Pain Relevance 0
Double mutant AdV additionally lacking the integrin-binding penton base RGD motif were shown to efficiently target epidermal growth factor receptor or epithelial cell adhesion molecules, depending on the choice of the bispecific linker, resulting in a relative glioma/normal brain transduction ratio of 60 times that achieved with native AdV.
Gene_expression (target) of epidermal growth factor receptor in brain associated with glioma and adhesions
3) Confidence 0.65 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 0.71 Pain Relevance 0.03
Among these components, epidermal growth factor receptor (EGFR), a membrane protein, has been well studied for its function in cancer biology.
Gene_expression (studied) of epidermal growth factor receptor associated with cancer
4) Confidence 0.65 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717822 Disease Relevance 0.81 Pain Relevance 0
Recently, the introduction of epidermal growth factor receptor (EGFR) inhibitors, such as cetuximab, together with PBT, has improved response and survival rates in these patients (Vermorken et al, 2008).
Gene_expression (introduction) of epidermal growth factor receptor
5) Confidence 0.65 Published 2010 Journal Br J Cancer Section Body Doc Link PMC2883700 Disease Relevance 0.70 Pain Relevance 0.07
In another study, overexpression of PLD2 resulted in transformation of fibroblasts overexpressing the epidermal growth factor receptor or c-Src [37].
Gene_expression (overexpressing) of epidermal growth factor receptor in fibroblasts
6) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.92 Pain Relevance 0
FAK is a downstream target of several growth factor receptors, including epidermal growth factor receptor and platelet-derived growth factor receptor, and upon activation FAK recruits a variety of signaling factors that can regulate cell adhesion and cell motility [111].
Gene_expression (target) of epidermal growth factor receptor in platelet associated with adhesions
7) Confidence 0.65 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.91 Pain Relevance 0

General Comments

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