INT172525

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Context Info
Confidence 0.73
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 4.17
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PSEN2) endoplasmic reticulum (PSEN2) embryo development (PSEN2)
protein complex (PSEN2) cytosol (PSEN2) peptidase activity (PSEN2)
Anatomy Link Frequency
MCF7 1
brain 1
PSEN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 7 92.00 High High
Serotonin 1 91.68 High High
Central nervous system 20 82.04 Quite High
Neuropeptide 3 79.32 Quite High
cytokine 14 61.92 Quite High
Inflammation 34 50.00 Quite Low
Rsd 18 5.00 Very Low Very Low Very Low
addiction 12 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 32 99.20 Very High Very High Very High
Lung Cancer 3 98.28 Very High Very High Very High
Glioblastoma 1 97.96 Very High Very High Very High
Cancer 268 97.08 Very High Very High Very High
Glioma 3 95.52 Very High Very High Very High
Brain Tumor 1 95.24 Very High Very High Very High
Inflammatory Breast Neoplasms 114 94.00 High High
Skin Cancer 5 92.16 High High
Breast Cancer 35 92.04 High High
Head & Neck Cancer 1 89.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Over 900 patients have been treated by gene transfer products (nonreplication-selective AdV p53, Aventis Pharma) over a period of 5 years.
Localization (selective) of AdV
1) Confidence 0.73 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 0.64 Pain Relevance 0.08
It has also been reported that Ad5-p53 suppresses the tumorigenic potential of human glioblastoma cells and inhibits cell growth in the rodent 9L glioma brain tumor (4, 13).
Localization (reported) of Ad5 in brain associated with glioblastoma, brain tumor and glioma
2) Confidence 0.73 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 1.73 Pain Relevance 0
In mammals, presenilins 1 and 2 (PSEN1 and PSEN2), which are processing enzymes of APP and the ApoE4 protein, are implicated in the etiology of AD (Walsh and Selkoe, 2004; Selkoe and Wolfe, 2007).
Localization (implicated) of PSEN2 associated with disease
3) Confidence 0.40 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2910937 Disease Relevance 0.16 Pain Relevance 0.16
Expression of the ER and PgR genes, c-myb, c-erb2, c-myc, c-fos, the epidermal growth factor receptor (EGFR) gene, and pS2 (a small secreted protein isolated from MCF7 cells after induction by 17?
Localization (secreted) of pS2 in MCF7
4) Confidence 0.32 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.64 Pain Relevance 0
In c, proposed localization of pS1 and pS2 promoters in the region upstream of the coding sequence of the pcnB gene is shown
Spec (proposed) Localization (localization) of pS2
5) Confidence 0.07 Published 2010 Journal Mol Genet Genomics Section Body Doc Link PMC2939334 Disease Relevance 0 Pain Relevance 0
35 boxes can be easily predicted for pS1, in the case of pS2, it is possible to predict only ?
Localization (case) of pS2
6) Confidence 0.07 Published 2010 Journal Mol Genet Genomics Section Body Doc Link PMC2939334 Disease Relevance 0 Pain Relevance 0
Note that there are perhaps at least two alternative start sites from pS2, located in the region between positions ?
Localization (located) of pS2
7) Confidence 0.07 Published 2010 Journal Mol Genet Genomics Section Body Doc Link PMC2939334 Disease Relevance 0 Pain Relevance 0

General Comments

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