INT172526

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Context Info
Confidence 0.51
First Reported 2000
Last Reported 2005
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 4.70
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RHOC) signal transduction (RHOC) plasma membrane (RHOC)
nucleus (RHOC) intracellular (RHOC) GTPase activity (RHOC)
RHOC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 28 78.16 Quite High
Chronic pancreatitis 8 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 28 100.00 Very High Very High Very High
Adenocarcinoma 205 99.80 Very High Very High Very High
Inflammatory Breast Neoplasms 122 99.40 Very High Very High Very High
Cancer 184 97.28 Very High Very High Very High
Metastasis 97 94.92 High High
Disease 18 91.16 High High
Clostridium Infection 4 89.56 High High
Carcinoma 7 72.28 Quite High
Breast Cancer 31 50.00 Quite Low
Syndrome 3 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown, both C3 exotransferase treatment and expression of dnRhoC did not significantly alter total levels of RhoC protein.
Neg (not) Regulation (alter) of RhoC protein
1) Confidence 0.51 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.16 Pain Relevance 0
Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and Caveolin-1

Background

Regulation (Regulation) of RhoC associated with pancreatic cancer
2) Confidence 0.22 Published 2005 Journal Mol Cancer Section Title Doc Link PMC1173138 Disease Relevance 0.89 Pain Relevance 0
This study also presents a fresh link to the regulation of RhoC-mediated migration and invasion, giving a functional role for RhoC in PC tumor cells.


Regulation (regulation) of RhoC associated with adenocarcinoma and cancer
3) Confidence 0.22 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.48 Pain Relevance 0.03
One effect that high cav-1 expression could have in PC cells is regulating RhoC activity, thus limiting cell migration and promoting growth.
Regulation (regulating) of RhoC associated with adenocarcinoma
4) Confidence 0.22 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.67 Pain Relevance 0
Two genes, RhoC GTPase and a novel gene, were found to be concordantly altered in 91% of the IBC specimens versus 0% of the stage-matched non-IBC tumors.
Regulation (altered) of RhoC associated with inflammatory breast neoplasms and cancer
5) Confidence 0.21 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.51 Pain Relevance 0.07

General Comments

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