INT172527

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Context Info
Confidence 0.60
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 4.76
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGFBP7) extracellular region (IGFBP7) cell adhesion (IGFBP7)
Anatomy Link Frequency
margin 2
internal 2
IGFBP7 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 76.96 Quite High
Inflammation 55 75.92 Quite High
anesthesia 2 65.20 Quite High
Osteoarthritis 4 48.08 Quite Low
fibrosis 12 39.12 Quite Low
metalloproteinase 13 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dermal Scarring 192 100.00 Very High Very High Very High
Reprotox - General 1 6 99.84 Very High Very High Very High
Breast Cancer 55 98.72 Very High Very High Very High
Cancer 153 98.40 Very High Very High Very High
Malignant Neoplastic Disease 8 98.12 Very High Very High Very High
Familial Combined Hyperlipidemia 254 87.84 High High
Inflammatory Breast Neoplasms 228 77.72 Quite High
Adenocarcinoma 3 71.20 Quite High
INFLAMMATION 37 68.24 Quite High
Obesity 16 67.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The differential expression of nine genes (AGT, AK5, CNR1, GALR2, IGFBP7, KISSR1, PLXDC1, PLXNC1 and PROK2) was successfully validated using quantitative real-time PCR (Figure S2 and Table S9).
Gene_expression (expression) of IGFBP7
1) Confidence 0.60 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.27 Pain Relevance 0.07
Ten of these 19 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5), demonstrated a statistically significant difference for the gene expression levels between keloid margin and internal control skin.
Gene_expression (expression) of IGFBP7 in internal associated with dermal scarring
2) Confidence 0.53 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.66 Pain Relevance 0
A statistically significant (P < .05) differential expression and a fold change of more than 2 were determined between keloid margin and internal control biopsy samples for 10 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5).
Gene_expression (expression) of IGFBP7 in internal associated with dermal scarring
3) Confidence 0.53 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.24 Pain Relevance 0
We validated the differential expression of nine genes (AGT, AK5, CNR1, GALR2, IGFBP7, KISSR1, PLXDC1, PLXNC1 and PROK2) using quantitative real-time PCR (Figure S2).
Gene_expression (expression) of IGFBP7
4) Confidence 0.46 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.33 Pain Relevance 0
Expression of cell growth related genes PCNA and IGFBP7 was downregulated by the high concentration of curcumin (Table 2).
Gene_expression (Expression) of IGFBP7
5) Confidence 0.27 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.05 Pain Relevance 0
A statistically significant (P < .05) differential expression and a fold change of more than 2 were determined between keloid margin and internal control biopsy samples for 10 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5).
Gene_expression (expression) of IGFBP7 in margin associated with dermal scarring
6) Confidence 0.18 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.24 Pain Relevance 0
Ten of these 19 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5), demonstrated a statistically significant difference for the gene expression levels between keloid margin and internal control skin.
Gene_expression (expression) of IGFBP7 in margin associated with dermal scarring
7) Confidence 0.18 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.66 Pain Relevance 0
Downregulation or loss of IGFBP-rP1 expression is associated with progression of breast cancer [43] and prostate cancer [44].
Gene_expression (expression) of IGFBP-rP1 associated with breast cancer and reprotox - general 1
8) Confidence 0.02 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.08 Pain Relevance 0.12
Transfection of IGFBP-rP1 in prostate cancer cells gives rise to a less malignant phenotype, in a manner that is directly proportional to the level of expression [44].
Gene_expression (Transfection) of IGFBP-rP1 associated with malignant neoplastic disease and reprotox - general 1
9) Confidence 0.02 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.23 Pain Relevance 0.17

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