INT172529

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Context Info
Confidence 0.48
First Reported 2000
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 16.69
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PGR) enzyme binding (PGR) DNA binding (PGR)
cell-cell signaling (PGR) cytoplasm (PGR) signal transduction (PGR)
Anatomy Link Frequency
uterine cervix 2
endometrium 2
PGR (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 18 99.82 Very High Very High Very High
Inflammation 124 86.24 High High
cytokine 26 73.24 Quite High
palliative 29 71.80 Quite High
Dismenorea 10 64.00 Quite High
antagonist 50 57.00 Quite High
cva 20 51.20 Quite High
Central nervous system 21 48.88 Quite Low
imagery 36 41.92 Quite Low
agonist 37 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 910 100.00 Very High Very High Very High
Inflammatory Breast Neoplasms 481 100.00 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 151 100.00 Very High Very High Very High
Triple Negative Breast Cancer 5 99.58 Very High Very High Very High
Breast Cancer 711 98.70 Very High Very High Very High
Disease 259 98.56 Very High Very High Very High
Endometriosis (extended) 40 97.08 Very High Very High Very High
Metastasis 94 94.52 High High
Uterine Fibroids 120 92.72 High High
Sprains And Strains 6 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The significant decrease in PgR expression with letrozole remained significant in the ER+, HER2+ subpopulation.
Negative_regulation (decrease) of Gene_expression (expression) of PgR
1) Confidence 0.48 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001223 Disease Relevance 0.35 Pain Relevance 0
In addition, more cases showed a reduction in progesterone receptor (PgR) expression following letrozole than anastrozole [97].
Negative_regulation (reduction) of Gene_expression (expression) of PgR
2) Confidence 0.39 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001217 Disease Relevance 0.45 Pain Relevance 0
Average tumor PgR expression decreased dramatically on letrozole treatment (P = 0.0001), and only 4.4% of surgical specimens exhibited an Allred score of between six and eight for PgR expression.
Negative_regulation (decreased) of Gene_expression (expression) of PgR associated with cancer
3) Confidence 0.35 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001223 Disease Relevance 0.37 Pain Relevance 0
In contrast, changes in PgR expression with tamoxifen therapy were not consistent, with both increases and decreases in expression frequently observed in the overall and ER+, HER2+ subpopulations.
Negative_regulation (decreases) of Gene_expression (expression) of PgR
4) Confidence 0.35 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001223 Disease Relevance 0.35 Pain Relevance 0
Letrozole, but not tamoxifen, significantly reduced the expression of estrogen-regulated proteins PgR and TFF1 [38].
Negative_regulation (reduced) of Gene_expression (expression) of PgR
5) Confidence 0.35 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001223 Disease Relevance 0.38 Pain Relevance 0
Interestingly, letrozole was effective even in marginally ER+ tumors and, unlike tamoxifen, consistently reduced the expression from estrogen-regulated genes (progesterone receptor and trefoil factor 1).
Negative_regulation (reduced) of Gene_expression (expression) of progesterone receptor associated with cancer
6) Confidence 0.35 Published 2007 Journal Breast Cancer Res Treat Section Abstract Doc Link PMC2001223 Disease Relevance 0.48 Pain Relevance 0
"Triple negativity" was defined as a lack of expression of ER, PgR, and HER2.
Negative_regulation (lack) of Gene_expression (expression) of PgR
7) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2972282 Disease Relevance 0.21 Pain Relevance 0
These tumors may share clinical and biologic properties with triple negative breast cancers (TNBCs) that lack expression of ER, progesterone receptor (PgR) and HER2 [5-8].
Negative_regulation (lack) of Gene_expression (expression) of PgR associated with triple negative breast cancer and cancer
8) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2972282 Disease Relevance 0.85 Pain Relevance 0.07
In addition, more cases showed a reduction in progesterone receptor (PgR) expression following letrozole than anastrozole [97].
Negative_regulation (reduction) of Gene_expression (expression) of progesterone receptor
9) Confidence 0.28 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001217 Disease Relevance 0.45 Pain Relevance 0
In general, the absence of estrogen receptor (ER) and progesterone receptor (PgR) expression has been correlated with a shorter disease-free survival time and overall poor clinical outcome of breast cancer patients, including those with IBC [19].
Negative_regulation (absence) of Gene_expression (expression) of PgR associated with inflammatory breast neoplasms, breast cancer and disease
10) Confidence 0.25 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.29 Pain Relevance 0.04
In general, the absence of estrogen receptor (ER) and progesterone receptor (PgR) expression has been correlated with a shorter disease-free survival time and overall poor clinical outcome of breast cancer patients, including those with IBC [19].
Negative_regulation (absence) of Gene_expression (expression) of progesterone receptor associated with inflammatory breast neoplasms, breast cancer and disease
11) Confidence 0.25 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.29 Pain Relevance 0.04
Compared with non-IBC LABC, IBC tumors frequently lacked expression of the cytosolic ER (44% of IBC tumors were ER positive versus 64% of LABC) and PgR (30% of IBC tumors were PgR positive versus 51% of LABC), regardless of menopausal status.
Negative_regulation (lacked) of Neg (lacked) Gene_expression (expression) of PgR associated with inflammatory breast neoplasms, endometriosis (extended), cancer and advanced or metastatic breast cancer
12) Confidence 0.25 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 3.26 Pain Relevance 0
There will also be great benefit in generating better mouse models of specific types of human breast cancer, ranging from triple negative breast cancer (oestrogen receptor negative, progesterone receptor negative and HER2 negative) to oestrogen receptor positive tumours.
Negative_regulation (negative) of Neg (negative) Gene_expression (negative) of progesterone receptor associated with cancer, triple negative breast cancer and breast cancer
13) Confidence 0.18 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397525 Disease Relevance 1.00 Pain Relevance 0
There will also be great benefit in generating better mouse models of specific types of human breast cancer, ranging from triple negative breast cancer (oestrogen receptor negative, progesterone receptor negative and HER2 negative) to oestrogen receptor positive tumours.
Negative_regulation (negative) of Neg (negative) Gene_expression (negative) of progesterone receptor associated with cancer, triple negative breast cancer and breast cancer
14) Confidence 0.18 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397525 Disease Relevance 1.00 Pain Relevance 0
Loss of PR expression has previously been attributed to a non-functional ER [28], which may be one reason for the absence of correlation between tumor estradiol and tumor VEGF.
Negative_regulation (Loss) of Gene_expression (expression) of PR associated with cancer
15) Confidence 0.17 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2279135 Disease Relevance 1.77 Pain Relevance 0
This parallelism between cervical ripening and symphyseal relaxation at term suggests that pubic symphyseal relaxation could be hormonally controlled by some mechanism of functional P4 withdrawal such as decreased expression of PR at the end of gestation.
Negative_regulation (decreased) of Gene_expression (expression) of PR associated with withdrawal
16) Confidence 0.17 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305330 Disease Relevance 0.19 Pain Relevance 0.27
1 suppresses expression of progesterone receptor (PR) suggesting that TGF?
Negative_regulation (suppresses) of Gene_expression (expression) of progesterone receptor
17) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0.23 Pain Relevance 0.14
1 mediated suppression of PR expression [19].
Negative_regulation (suppression) of Gene_expression (expression) of PR
18) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
Recently, we have demonstrated that before parturition, diminished responsiveness of the cervix to P4 might be caused by a decrease in progesterone receptor (PR) levels and this may be the mechanism of functional P4 withdrawal in the uterine cervix at term [21].
Negative_regulation (decrease) of Gene_expression (levels) of progesterone receptor in uterine cervix associated with withdrawal
19) Confidence 0.13 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305330 Disease Relevance 0.07 Pain Relevance 0.22
1 down-regulates PR expression [19] and inhibits cell proliferation and migration [32].
Negative_regulation (down-regulates) of Gene_expression (expression) of PR
20) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0.13 Pain Relevance 0.06

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