INT172551

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Context Info
Confidence 0.07
First Reported 2002
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 38
Total Number 38
Disease Relevance 20.83
Pain Relevance 3.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INCENP) chromosome segregation (INCENP) chromosome (INCENP)
cytoskeleton (INCENP) nucleus (INCENP) protein complex (INCENP)
Anatomy Link Frequency
macrophage 2
neuronal 1
nerve 1
long bones 1
platelet 1
INCENP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 390 100.00 Very High Very High Very High
Inflammatory response 21 100.00 Very High Very High Very High
adenocard 6 100.00 Very High Very High Very High
agonist 61 99.74 Very High Very High Very High
Arthritis 63 98.56 Very High Very High Very High
cytokine 195 97.08 Very High Very High Very High
Hippocampus 25 95.20 Very High Very High Very High
metalloproteinase 66 94.76 High High
corticosteroid 20 92.44 High High
Inflammatory marker 10 92.32 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 434 100.00 Very High Very High Very High
Cancer 381 100.00 Very High Very High Very High
Hypercalcemia 188 100.00 Very High Very High Very High
Metastasis 33 100.00 Very High Very High Very High
Adhesions 26 100.00 Very High Very High Very High
Skin Cancer 5 100.00 Very High Very High Very High
Apoptosis 275 99.48 Very High Very High Very High
Hepatocellular Cancer 85 98.96 Very High Very High Very High
Arthritis 82 98.56 Very High Very High Very High
Targeted Disruption 162 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unfortunately, from the many mechanisms, no single one shows a stringent correlation with the inhibition of bone resorption in vivo when different bisphosphonates of various potencies are investigated.
Negative_regulation (inhibition) of in vivo associated with hypercalcemia
1) Confidence 0.07 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138713 Disease Relevance 0.33 Pain Relevance 0.05
As regards tumor bone resorption, bisphosphonates very effectively inhibit tumoral bone resorption both in vitro and in vivo.
Negative_regulation (inhibit) of in vitro associated with cancer and hypercalcemia
2) Confidence 0.07 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138713 Disease Relevance 1.09 Pain Relevance 0.05
As regards tumor bone resorption, bisphosphonates very effectively inhibit tumoral bone resorption both in vitro and in vivo.
Negative_regulation (inhibit) of in vivo associated with cancer and hypercalcemia
3) Confidence 0.07 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138713 Disease Relevance 1.09 Pain Relevance 0.05
Furthermore, bisphosphonates can inhibit the adhesion of tumor cells to mineralized matrices in vitro, both when the cells or the matrix are treated [13,14].
Negative_regulation (inhibit) of in vitro associated with cancer and adhesions
4) Confidence 0.07 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138713 Disease Relevance 1.48 Pain Relevance 0.03
In vivo, both the hypercalcemia induced by the tumor [10] and the development of the metastases [11] are diminished.
Negative_regulation (diminished) of In vivo associated with cancer, hypercalcemia and metastasis
5) Confidence 0.07 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138713 Disease Relevance 1.35 Pain Relevance 0.04
In vitro, bisphosphonates decrease the destruction of bone in embryonic long bones and in neonatal calvaria [5].
Negative_regulation (decrease) of In vitro in long bones
6) Confidence 0.07 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138713 Disease Relevance 0.51 Pain Relevance 0
Finally, there is now evidence that bisphosphonates can decrease multiplication of tumor cells in vitro and can also induce their apoptosis by inhibiting the mevalonate pathway (Fig. 3) [15].


Negative_regulation (decrease) of in vitro associated with cancer and apoptosis
7) Confidence 0.07 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138713 Disease Relevance 1.33 Pain Relevance 0.03
Thus, it is advantageous to establish the in vitro model using the shortest exposure time possible.
Negative_regulation (establish) of in vitro
8) Confidence 0.04 Published 2010 Journal Combinatorial Chemistry & High Throughput Screening Section Body Doc Link PMC2908937 Disease Relevance 0.59 Pain Relevance 0.03
We demonstrated that ADRB3 agonists are able to inhibit in-vitro spontaneous contractions of myometrial strips, via a cyclic AMP-mediated pathway.
Negative_regulation (inhibit) of in-vitro associated with agonist
9) Confidence 0.04 Published 2007 Journal BMC Pregnancy Childbirth Section Abstract Doc Link PMC1892055 Disease Relevance 0.08 Pain Relevance 0.08
In vitro, it is a potent inhibitor of both 1?
Negative_regulation (inhibitor) of In vitro
10) Confidence 0.03 Published 2008 Journal Ann Clin Microbiol Antimicrob Section Body Doc Link PMC2253556 Disease Relevance 0.26 Pain Relevance 0.04
In vivo suppression also requires B7 expression on effector cells.
Negative_regulation (suppression) of In vivo
11) Confidence 0.03 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0.04
As a result increase in concentration decreases in vitro ocular availability.
Negative_regulation (decreases) of in vitro
12) Confidence 0.02 Published 2008 Journal AAPS J Section Body Doc Link PMC2751374 Disease Relevance 0.11 Pain Relevance 0.03
Studies on in vitro corneal permeation of flurbiprofen have revealed that increase in the concentration of drug in aqueous drops decreased the % permeation or in vitro ocular availability.
Negative_regulation (decreased) of in vitro
13) Confidence 0.02 Published 2008 Journal AAPS J Section Body Doc Link PMC2751374 Disease Relevance 0.24 Pain Relevance 0.03
They also have been demonstrated to inhibit human platelet activity in vitro [122].
Negative_regulation (inhibit) of in vitro in platelet
14) Confidence 0.02 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852848 Disease Relevance 0.55 Pain Relevance 0.12
Olive oil phenolics have been found to decrease arachidonic acid release and arachidonic acid metabolite synthesis in vitro and both of these are involved in the inflammatory process [109].
Negative_regulation (decrease) of in vitro associated with inflammation
15) Confidence 0.02 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852848 Disease Relevance 1.32 Pain Relevance 0.53
In vitro inhibition of NF-?
Negative_regulation (inhibition) of In vitro
16) Confidence 0.02 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1413525 Disease Relevance 0.61 Pain Relevance 0.24
Finally, we tested the ability of RU to reduce rat macrophage inflammatory responses in vitro.
Negative_regulation (reduce) of in vitro in macrophage associated with inflammatory response
17) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374451 Disease Relevance 0.79 Pain Relevance 0.39
This property correlated with RU-mediated inhibition of murine macrophage activation and inflammatory mediator release in vitro (Figures 3 and 4).
Negative_regulation (inhibition) of in vitro in macrophage associated with inflammation
18) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374451 Disease Relevance 0.73 Pain Relevance 0.46
Inhibition of BChE by OP nerve agents in vitro
Negative_regulation (Inhibition) of in vitro in nerve
19) Confidence 0.01 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2415180 Disease Relevance 0.28 Pain Relevance 0
The clinical activity of HDAC inhibitors alone is very scarce, although it has been shown that most of them inhibit histone deacetylase activity in vitro, synergizing with all-trans retinoic acid (ATRA) in inducing differentiation of myeloid blast cells.
Negative_regulation (inhibit) of in vitro in blast cells
20) Confidence 0.01 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 1.03 Pain Relevance 0

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