INT172554

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Context Info
Confidence 0.16
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.48
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp1a) extracellular region (Mmp1a) proteinaceous extracellular matrix (Mmp1a)
Anatomy Link Frequency
chondrocytes 2
articular 2
joint 2
stromal cells 2
stem cell 2
Mmp1a (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 153 100.00 Very High Very High Very High
rheumatoid arthritis 167 99.40 Very High Very High Very High
Inflammation 171 96.88 Very High Very High Very High
methotrexate 21 93.36 High High
Osteoarthritis 37 85.00 Quite High
antagonist 30 82.96 Quite High
Leflunomide 2 68.64 Quite High
cytokine 80 67.00 Quite High
Kinase C 1 66.64 Quite High
Arthritis 12 58.40 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 5 99.84 Very High Very High Very High
Rheumatoid Arthritis 172 99.40 Very High Very High Very High
Stress 24 99.18 Very High Very High Very High
Osteoarthritis 38 98.80 Very High Very High Very High
INFLAMMATION 185 96.88 Very High Very High Very High
Osteogenic Sarcomas 3 92.56 High High
Adhesions 17 90.24 High High
Breast Cancer 26 89.28 High High
Hyperplasia 4 88.00 High High
Malignant Neoplastic Disease 3 85.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, Manacu et al. [72] found that, in primary cultures of human osteoarthritic chondrocytes, the presence of ET-1 in the medium triggered increased production of MMP-1 and MMP-13.
Positive_regulation (increased) of Gene_expression (production) of MMP-1 in chondrocytes associated with osteoarthritis
1) Confidence 0.16 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.66 Pain Relevance 0.17
Factors other than oxidative stress, such as ozone and lipid peroxides also induce collagen I and MMP-1 gene expression (Choi et al 1994).
Positive_regulation (induce) of Gene_expression (expression) of MMP-1 associated with stress and metalloproteinase
2) Confidence 0.08 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.53 Pain Relevance 0.32
One of the triggering factors appears to be articular hypoxia, which stimulates both synthesis of proangiogenic factors but also the expression of chemotactic factors, MMPs such as MMP-1 and MMP-3 (combined with a downregulation of TIMP-1 in RASFs), and osteoclastogenic factors such as inhibitor of differentiation [54].
Positive_regulation (stimulates) of Gene_expression (expression) of MMP-1 in articular associated with hypoxia and metalloproteinase
3) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.53 Pain Relevance 0.33
Finally, it has been shown that RA synovial fibroblasts exhibit increased production of MMPs (MMP-1, MMP-3, MMP-13, MMP-14 and MMP-15) and contribute significantly to the joint destruction observed in RA [53,54].
Positive_regulation (increased) of Gene_expression (production) of MMP-1 in joint associated with metalloproteinase and rheumatoid arthritis
4) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 0.93 Pain Relevance 0.65
The finding of an increased expression of MMP-1 corroborates previous findings in treated periodontal tissues [33].
Positive_regulation (increased) of Gene_expression (expression) of MMP-1
5) Confidence 0.06 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.28 Pain Relevance 0
Derenne et al. showed that the bisphosphonates pamidronate and zoledronate inhibited interleukin-6-induced production of matrix metalloproteinase-1 by bone marrow stromal cells [13].
Positive_regulation (interleukin-6-induced) of Gene_expression (production) of matrix metalloproteinase-1 in stromal cells associated with metalloproteinase
6) Confidence 0.05 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138714 Disease Relevance 0.71 Pain Relevance 0.05
B1 by small interfering RNA abrogated the capacity of RA bone marrow CD34+ cells to differentiate into fibroblast-like cells and to produce MMP-1 and vascular endothelial growth factor upon stimulation with stem cell factor, granulocyte-macrophage colony stimulating factor and TNF-?
Positive_regulation (upon) of Gene_expression (produce) of MMP-1 in stem cell associated with metalloproteinase and rheumatoid arthritis
7) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1526601 Disease Relevance 0.85 Pain Relevance 0.52

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