INT172558

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 17
Disease Relevance 8.92
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdh1) cell adhesion (Cdh1) Golgi apparatus (Cdh1)
plasma membrane (Cdh1) cytoplasm (Cdh1)
Anatomy Link Frequency
enteroendocrine cells 1
lymphocytes 1
intestinal epithelium 1
skin 1
basement membranes 1
Cdh1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 32 98.68 Very High Very High Very High
Crohn's disease 63 96.48 Very High Very High Very High
metalloproteinase 9 96.40 Very High Very High Very High
antagonist 16 67.20 Quite High
Inflammation 73 66.64 Quite High
Inflammatory response 11 41.76 Quite Low
addiction 9 39.36 Quite Low
substance P 3 18.00 Low Low
Kinase C 13 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 103 100.00 Very High Very High Very High
Cancer 344 99.84 Very High Very High Very High
Adenoma 29 99.84 Very High Very High Very High
Non-small-cell Lung Cancer 24 99.84 Very High Very High Very High
Bladder Cancer 3 99.52 Very High Very High Very High
Leukemia 4 99.40 Very High Very High Very High
Microphthalmia 23 99.36 Very High Very High Very High
Disease 130 96.48 Very High Very High Very High
Volume Depletion And Dehydration 7 96.32 Very High Very High Very High
Apoptosis 133 95.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Histochemical analysis of the colon and small intestine from induced Cre+Cdh1fl/fl mice with PAS and AB staining revealed that the number of mucus producing goblet cells was strongly reduced (Fig. 3C and 3D, and data not shown).
Positive_regulation (induced) of Cdh1fl in goblet cells
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.05 Pain Relevance 0
The number of the scarce enteroendocrine cells, as evaluated by synaptophysin staining, did not appear to be changed in Cre+Cdh1fl/fl mice (data not shown).


Positive_regulation (changed) of Cdh1fl in enteroendocrine cells
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0 Pain Relevance 0
Our results demonstrate that these two mechanisms of host defense are both dependent on E-cadherin.
Positive_regulation (dependent) of E-cadherin
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.70 Pain Relevance 0.24
This role of E-cadherin for the assembly of other junctional complexes including desmosomes, tight junctions, and gap junctions [42] has been suggested to be related to the function of adherens junctions to establish cell polarity [41].
Positive_regulation (role) of E-cadherin
4) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.23 Pain Relevance 0
Our data reveal that E-cadherin is required for correct maturation and placement of Paneth cells, supporting its role in cell polarization [6].
Positive_regulation (required) of E-cadherin in Paneth cells
5) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.06 Pain Relevance 0
Therefore, our study by directly targeting E-cadherin now confirms and expands these previous indirect findings and further clarifies E-cadherin's critical role as an anti-apoptotic and survival factor of the intestinal epithelium.
Positive_regulation (targeting) of E-cadherin in intestinal epithelium associated with apoptosis
6) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.30 Pain Relevance 0
Interestingly, E-cadherin was found to be required for tight junction formation but not desmosome assembly in skin [41].
Positive_regulation (required) of E-cadherin in skin
7) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.19 Pain Relevance 0
These changes were accompanied by severe EC damage, decreased E-cadherin RNA level, elevated IFN-?
Positive_regulation (elevated) of E-cadherin
8) Confidence 0.26 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2715133 Disease Relevance 0.09 Pain Relevance 0.04
Only in the TRD group, IRS for E-cadherin was significantly increased in adenoma (1.2 ± 0.2) compared to normal mucosa (0.3 ± 0.1) (P ?
Positive_regulation (increased) of E-cadherin associated with adenoma
9) Confidence 0.14 Published 2010 Journal Journal of Carcinogenesis Section Body Doc Link PMC2862504 Disease Relevance 0.52 Pain Relevance 0
has been shown to upregulate E-cadherin in NSCLC, there are no
Positive_regulation (upregulate) of E-cadherin associated with non-small-cell lung cancer
10) Confidence 0.11 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 0.61 Pain Relevance 0.05
Noted differences of the cytospin preparations relative to the heterotransplanted tumors were a decrease in keratin and EFGr staining and an increase in E-cadherin and CD44 positivity.
Positive_regulation (increase) of E-cadherin associated with cancer
11) Confidence 0.11 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 1.26 Pain Relevance 0
TFE3 and TFEB have been identified as cell type-specific leukemia inhibitory factor-responsive activators of E-cadherin [54].


Positive_regulation (activators) of E-cadherin associated with leukemia
12) Confidence 0.11 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 1.31 Pain Relevance 0
First, we noted that Lm uses InlA to access E-cadherin as it becomes exposed at multicellular junctions (MCJs, Figure 6A) [30].
Positive_regulation (access) of E-cadherin
13) Confidence 0.10 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0.07 Pain Relevance 0
Compared to isotype controls, USC-HN1 displays significantly increased staining of FABP5, E-cadherin, and CD24.
Positive_regulation (increased) of E-cadherin
14) Confidence 0.07 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 0.42 Pain Relevance 0
7 by lymphocytes increases adhesion to E-cadherin expressing bladder cancer targets, indicating a role of integrin ?
Positive_regulation (increases) of E-cadherin in lymphocytes associated with bladder cancer and adhesions
15) Confidence 0.05 Published 2008 Journal Perspectives in Medicinal Chemistry Section Body Doc Link PMC2746574 Disease Relevance 0.95 Pain Relevance 0.03
This was concluded from experiments in keratinocytes which showed that Rac 1 inactivation by transfection with a dominant-inactive mutant as well as inactivation of Rho A by C3 toxin for 25 min was sufficient to displace E-cadherin but not desmoplakin from cell junctions (Braga et al. 1997).
Neg (not) Positive_regulation (displace) of E-cadherin in keratinocytes
16) Confidence 0.05 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.50 Pain Relevance 0
Attachment of tumor cells to basement membranes and to other cells is mediated through cell adhesion molecules such as laminin and E-cadherin.
Positive_regulation (mediated) of E-cadherin in basement membranes associated with cancer and adhesions
17) Confidence 0.04 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138714 Disease Relevance 1.67 Pain Relevance 0.05

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