INT172559

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Context Info
Confidence 0.02
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 21.49
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Proc) extracellular space (Proc) extracellular region (Proc)
Anatomy Link Frequency
skeleton 1
osteoclast 1
parathyroid 1
microglia 1
vascular endothelium 1
Proc (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 29 100.00 Very High Very High Very High
chemokine 15 100.00 Very High Very High Very High
Inflammation 77 99.60 Very High Very High Very High
palliative 10 99.32 Very High Very High Very High
Pain 23 93.40 High High
glial activation 2 92.32 High High
rheumatoid arthritis 50 87.80 High High
Central nervous system 20 87.44 High High
bDMF 49 84.44 Quite High
cINOD 112 82.36 Quite High
Disease Link Frequency Relevance Heat
Cancer 972 100.00 Very High Very High Very High
Hypercalcemia 122 99.98 Very High Very High Very High
Breast Cancer 296 99.86 Very High Very High Very High
Osteoporosis 157 99.66 Very High Very High Very High
Metastasis 829 99.60 Very High Very High Very High
INFLAMMATION 94 99.60 Very High Very High Very High
Adhesions 18 99.44 Very High Very High Very High
Disease 222 99.40 Very High Very High Very High
Peptic Ulcer 6 99.28 Very High Very High Very High
Ulcers 33 98.94 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
recruits different immune cells to the tumor microenvironment: monocytes and macrophages promote tumor invasion, angiogenesis and metastasis whereas mast cells secrete numerous tumor promoting factors [83].
Localization (secrete) of factors in mast cells associated with cancer and metastasis
1) Confidence 0.02 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 1.27 Pain Relevance 0.04
The first step is the surgical debridement, supported by superficial destruction and detachment of attached micro-organisms.The critically colonised (microbial bio-film) or infected wound can be antiseptically treated with low temperature plasma combined with degradation of bacterial endotoxins.By configuration of the low temperature plasma, it is possible that the plasma penetrates only into the superficial layer of the wound without any toxic effects on deeper layers of regenerative granulation tissue, and the reduced energy in the deeper layers can regulate inflammation on a reparative level and support cell proliferation and cell functions (phagocytosis, releasing of growth factors) with the consequence of stimulation on wound healing.
Localization (releasing) of factors in support cell associated with inflammation, wound healing and injury
2) Confidence 0.01 Published 2008 Journal GMS Krankenhaushygiene Interdisziplinar Section Body Doc Link PMC2831521 Disease Relevance 0.91 Pain Relevance 0.08
Thus, drugs that arrest ulcer progression by antioxidant action, and also promote secretion of PGE2, gastric mucus, and growth factors would accelerate gastric ulcer healing.
Localization (secretion) of factors associated with ulcers and peptic ulcer
3) Confidence 0.01 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.61 Pain Relevance 0.15
Multiple tumor-secreted factors act on the bone microenvironment to drive a feed-forward cycle of tumor growth.
Localization (secreted) of factors associated with cancer
4) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2731927 Disease Relevance 1.26 Pain Relevance 0.19
Because breast cancer cells secrete factors which stimulate osteoclast formation and bone resorption in osteolytic metastases, we analyzed osteoclast number at sites of bone metastases from 2ME2- and SD-208-treated mice.
Spec (analyzed) Localization (secrete) of factors in osteoclast associated with breast cancer, hypercalcemia and metastasis
5) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.48 Pain Relevance 0
in tumor cells decreases bone metastases by suppressing tumor secretion of proangiogenic factors and blocking vessel formation.


Localization (secretion) of factors associated with cancer and metastasis
6) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.60 Pain Relevance 0
Breast cancers that metastasize to bone secrete factors, such as parathyroid hormone-related protein (PTHrP) and interleukin-11 (IL-11), that stimulate osteoclastic bone destruction and the release and activation of growth factors immobilized in the bone matrix.
Localization (secrete) of factors in parathyroid associated with breast cancer and osteoporosis
7) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.24 Pain Relevance 0.17
signaling pathways regulate tumor-secreted factors such as CXCR4 which promotes tumor cell homing to the bone [50], and VEGF which stimulates tumor angiogenesis and increases both osteoclast [65], [69] and osteoblast activity [61].
Localization (secreted) of factors in osteoblast associated with cancer and osteoporosis
8) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.35 Pain Relevance 0
Further characterization of the localization of each of these factors in taste bud-containing regions could provide clues as to their specific roles in taste bud development.


Localization (localization) of factors in taste bud
9) Confidence 0.01 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.08 Pain Relevance 0.20
Therefore, evidence has started to accumulate that the function of microglia is neuroprotection in young individuals (by secretion of neurotrophic factors and anti-inflammatory cytokines) and that “senescent” microglia contribute to the onset of sporadic AD (Streit et al., 2004, 2009).
Localization (secretion) of factors in microglia associated with inflammation, disease and cytokine
10) Confidence 0.01 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2893374 Disease Relevance 1.42 Pain Relevance 0.23
and neurons and secretion of growth factors, early in the disease (Wyss-Coray et al., 2003; Maragakis et al., 2006; Wyss-Coray, 2006).
Localization (secretion) of factors in neurons associated with disease
11) Confidence 0.01 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2893374 Disease Relevance 0.75 Pain Relevance 0.46
This endothelium also blocks the transfer of lipid particles into the arterial wall, inhibits the release of chemokines/cytokines/growth factors and prevents adhesion of platelets and monocytes to the vascular endothelium.
Localization (release) of factors in vascular endothelium associated with chemokine, adhesions and cytokine
12) Confidence 0.01 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.68 Pain Relevance 0.19
This seed and soil hypothesis is supported by the fact that bone is a repository for a number of growth factors and that osteoclastic bone resorption releases these growth factors.
Localization (releases) of factors associated with hypercalcemia and osteoporosis
13) Confidence 0.01 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138714 Disease Relevance 2.03 Pain Relevance 0.07
First, and most probable, the decrease in osteoclastic bone resorption makes the skeleton a less hospitable environment for the tumor cells, by reducing the release of bone-derived growth factors that may stimulate tumor growth or production of osteolytic factors.
Localization (release) of factors in skeleton associated with cancer, hypercalcemia and osteoporosis
14) Confidence 0.01 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138714 Disease Relevance 1.93 Pain Relevance 0
More work is needed to determine whether bisphosphonates truly have antitumor activity in humans, or whether the reduction in tumor burden in bone is due to the reduction of bone-derived growth factors released into the local microenvironment as a consequence of inhibiting osteoclastic bone resorption.
Localization (released) of factors associated with cancer, hypercalcemia and osteoporosis
15) Confidence 0.01 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138714 Disease Relevance 1.50 Pain Relevance 0
This production results in the release of growth factors, such as transforming growth factor-?
Localization (release) of factors
16) Confidence 0.01 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138714 Disease Relevance 1.81 Pain Relevance 0
As the tumor develops further, additional factors are also secreted.
Localization (secreted) of factors associated with cancer
17) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727886 Disease Relevance 0.78 Pain Relevance 0
These findings have contributed to the rationale for the development of targeted therapies that delete B cells [60] or that attenuate the function of secreted and membrane associated factors that contribute to B cell accumulation and survival at sites of disease [61].
Localization (secreted) of factors in B cell associated with disease
18) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC2833442 Disease Relevance 0.77 Pain Relevance 0.30

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