INT172592

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Context Info
Confidence 0.28
First Reported 2001
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 6.25
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (PTH1R) plasma membrane (PTH1R) nucleus (PTH1R)
intracellular (PTH1R) cytoplasm (PTH1R) signal transducer activity (PTH1R)
Anatomy Link Frequency
chondrocyte 1
endochondral bone 1
lungs 1
vein 1
PTH1R (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 464 100.00 Very High Very High Very High
fibrosis 40 98.00 Very High Very High Very High
Inflammation 67 93.84 High High
ketamine 8 93.68 High High
cytokine 1 90.64 High High
agonist 1 89.28 High High
Arthritis 3 25.04 Quite Low
anesthesia 9 9.68 Low Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fat Embolism 456 100.00 Very High Very High Very High
Chondrodysplasia 3 98.88 Very High Very High Very High
Fibrosis 40 98.00 Very High Very High Very High
Dwarfism 1 96.72 Very High Very High Very High
Edema 80 94.72 High High
INFLAMMATION 66 93.84 High High
Hypercalcemia 1 93.28 High High
Kidney Stones 1 92.56 High High
Cv Unclassified Under Development 16 86.12 High High
Adult Respiratory Distress Syndrome 24 84.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, other chondrocyte-associated genes, such as sox5, IHH, and PTHR1 were also up-regulated.
Positive_regulation (regulated) of PTHR1 in chondrocyte
1) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2579486 Disease Relevance 0 Pain Relevance 0.05
In our experimental study, PFE was induced by using linoleic acid, which is a kind of FFA that we used in order to mainly focus on the natural evolution of FFA and the role it plays in nontraumatic PFE.
Positive_regulation (induced) of PFE associated with cva
2) Confidence 0.26 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526389 Disease Relevance 0.94 Pain Relevance 0.33
PFE was induced by an intravenous injection of 0.2 mL linoleic acid in 24 rabbits.
Positive_regulation (induced) of PFE associated with cva
3) Confidence 0.26 Published 2008 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2526389 Disease Relevance 0.43 Pain Relevance 0.22
In our study, PFE was induced by injecting linoleic acid through the intravenous route in all 24 rabbits.
Positive_regulation (induced) of PFE associated with cva
4) Confidence 0.26 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526389 Disease Relevance 0.54 Pain Relevance 0.24
According to these criteria, it was not clear whether or not PFE was artificially induced in the experiment.
Spec (whether) Positive_regulation (induced) of PFE associated with cva
5) Confidence 0.26 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526389 Disease Relevance 0.99 Pain Relevance 0.42
Following this, we analyze the CT and pathologic findings of the sequential changes of the experimental PFE using a FFA, and we correlated this with the CT and pathologic findings of experimentally induced PFE in rabbit lungs.


Positive_regulation (induced) of PFE in lungs associated with cva
6) Confidence 0.26 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526389 Disease Relevance 0.92 Pain Relevance 0.33
In conclusion, PFE was caused by using linoleic acid which is kind of free fatty acid and this study served as one model of the occurrence of nontraumatic PFE.
Positive_regulation (caused) of PFE associated with cva
7) Confidence 0.18 Published 2008 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2526389 Disease Relevance 0.97 Pain Relevance 0.35
The dose of linoleic acid was decided upon by conducting a pilot study, and we also based our decision on the results from the study by Baker et al. (11), in which PFE was induced in dogs by using oleic acid (0.07 mL/kg).
Positive_regulation (induced) of PFE associated with cva
8) Confidence 0.18 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526389 Disease Relevance 0.67 Pain Relevance 0.29
In 24 rabbits, PFE was induced by intravenous injection through the ear vein with a 1-mL syringe loaded with 0.2 mL dose of linoleic acid (cis-9, cis-12- octadecadienoic acid, 99% purity; Sigma, St.
Positive_regulation (induced) of PFE in vein associated with cva
9) Confidence 0.18 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526389 Disease Relevance 0.41 Pain Relevance 0.22
In addition, naturally occurring point mutations of a histidine at the junction between IC1 and the TM2 and a threonine in TM6 of the human PTH1 receptor have been reported to be associated with constitutive activation of the PTH1 receptor in Jansen-type metaphyseal chondrodysplasia, a rare genetic form of short-limbed dwarfism caused by delayed endochondral bone formation that is associated with severe hypercalcemia and hypercalciuria [18].
Positive_regulation (activation) of PTH1 receptor in endochondral bone associated with hypercalcemia, dwarfism, kidney stones and chondrodysplasia
10) Confidence 0.09 Published 2001 Journal Genome Biol Section Body Doc Link PMC138994 Disease Relevance 0.38 Pain Relevance 0.04

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