INT1726

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1979
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 65
Total Number 66
Disease Relevance 38.81
Pain Relevance 44.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Kitl) extracellular region (Kitl) cell adhesion (Kitl)
plasma membrane (Kitl) cytoskeleton (Kitl) cytoplasm (Kitl)
Anatomy Link Frequency
gray matter 14
neurons 4
spinal 2
ventral 2
dorsal 2
Kitl (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 272 100.00 Very High Very High Very High
Pain 110 100.00 Very High Very High Very High
Raphe magnus 50 100.00 Very High Very High Very High
Opioid 32 100.00 Very High Very High Very High
Enkephalin 17 100.00 Very High Very High Very High
mu opioid receptor 15 100.00 Very High Very High Very High
Glutamate 15 100.00 Very High Very High Very High
Raphe 13 100.00 Very High Very High Very High
midbrain 11 100.00 Very High Very High Very High
Dynorphin 7 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 576 100.00 Very High Very High Very High
Urological Neuroanatomy 348 100.00 Very High Very High Very High
Pain 89 100.00 Very High Very High Very High
Nociception 55 99.74 Very High Very High Very High
Overactive Bladder 5 99.32 Very High Very High Very High
Head & Neck Cancer 3 99.08 Very High Very High Very High
Anxiety Disorder 4 98.92 Very High Very High Very High
Sprains And Strains 14 98.76 Very High Very High Very High
Neuropathic Pain 12 98.56 Very High Very High Very High
Intractable Pain 2 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, a slight elevation of Con A-induced proliferation was observed 120 hr after morphine pellet implantation.
Positive_regulation (elevation) of Con associated with morphine
1) Confidence 0.70 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3385646 Disease Relevance 0.19 Pain Relevance 0.70
In contrast, in the VA-HIT study, gemfibrozil increased HDL-C on average by 7.5% with a 2% reduction in risk correlated with every 1% increase in HDL-C (Rubenset al 2001).
Positive_regulation (increased) of C on associated with disorder of lipid metabolism
2) Confidence 0.49 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.05 Pain Relevance 0.04
While simvastatin plus ezetimibe decreased LDL-C by 57%, HDL-C only increased by 10% compared to baseline.
Positive_regulation (increased) of C on associated with disorder of lipid metabolism
3) Confidence 0.45 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.61 Pain Relevance 0
The analgesic effect of electrical stimulation of the periaqueductal gray matter (PAG) was studied in mice selectively bred for high and low stress-induced analgesia (HA and LA lines, respectively).
Positive_regulation (stimulation) of periaqueductal gray in gray matter associated with stress, analgesic, urological neuroanatomy, central grey and analgesia
4) Confidence 0.19 Published 1989 Journal Brain Res. Section Abstract Doc Link 2743148 Disease Relevance 0.37 Pain Relevance 0.81
This may be because patients on imatinib have high concentrations of stem cell factor.
Positive_regulation (concentrations) of stem cell factor in stem cell
5) Confidence 0.10 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 0.82 Pain Relevance 0
By measuring the green fluorescence accumulating in spines a and b (Ga and Gb), we estimated how efficiently these spines captured PSD-95-paGFP* (Figure 4B and 4C, +60 min).
Positive_regulation (accumulating) of Gb in spines
6) Confidence 0.08 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0
The analgesic effect of electrical stimulation of the periaqueductal gray matter (PAG) was studied in 4 strains of mice: C57BL/6By (C57), BALB/cBy (BALB), CXBH, and CXBK.
Positive_regulation (stimulation) of periaqueductal gray in PAG associated with analgesic, urological neuroanatomy, sprains and strains and central grey
7) Confidence 0.05 Published 1990 Journal Brain Res. Section Abstract Doc Link 2154297 Disease Relevance 0.46 Pain Relevance 0.88
Cytokine production was promoted with ConA, LPS, or PMA plus ionomycin, and was detected with the enzyme-linked immunosorbent assay.
Positive_regulation (promoted) of ConA
8) Confidence 0.05 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 16225758 Disease Relevance 0.09 Pain Relevance 0
Upon ConA stimulation, SM735 suppressed IFN-gamma in a dose-dependent manner, but did not affect IL-2 secretion.
Positive_regulation (stimulation) of ConA
9) Confidence 0.05 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 16225758 Disease Relevance 0.05 Pain Relevance 0
When gD binds to its receptors, there are conformational changes in gD which apparently activate gB and gH/gL, so that these glycoproteins promote fusion involving the virion envelope and cellular membranes [4-6].
Positive_regulation (activate) of gB
10) Confidence 0.02 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.53 Pain Relevance 0
Electrical stimulation of mesencephalic periaqueductal gray matter (PAG) is known to have an aversive effect and elicits spontaneous instrumental escape behavior.
Positive_regulation (stimulation) of periaqueductal gray in gray matter associated with urological neuroanatomy and central grey
11) Confidence 0.01 Published 1999 Journal Metab Brain Dis Section Abstract Doc Link 10646689 Disease Relevance 0.36 Pain Relevance 0.14
Seven patients suffering intractable pain from head and neck cancer (age 48-73, mean 57.5 years) underwent acute stimulation of dorsal periaqueductal gray matter (PAG) with immediate cessation of pain.
Positive_regulation (stimulation) of periaqueductal gray in head associated with pain, intractable pain, urological neuroanatomy, head & neck cancer and central grey
12) Confidence 0.01 Published 1987 Journal Pacing Clin Electrophysiol Section Abstract Doc Link 2436181 Disease Relevance 0.76 Pain Relevance 0.42
Several tyrosine kinase growth factor oncoproteins activate the PI3-kinase pathway including EGFR (an ARE-gene), PDGFR, VEGFR, stem-cell factor (kit, an ARE-gene) and hepatocyte growth factor (met).
Positive_regulation (activate) of stem-cell factor in hepatocyte
13) Confidence 0.01 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.59 Pain Relevance 0.18
Seven patients suffering intractable pain from head and neck cancer (age 48-73, mean 57.5 years) underwent acute stimulation of dorsal periaqueductal gray matter (PAG) with immediate cessation of pain.
Positive_regulation (stimulation) of periaqueductal gray in neck associated with pain, intractable pain, urological neuroanatomy, head & neck cancer and central grey
14) Confidence 0.00 Published 1987 Journal Pacing Clin Electrophysiol Section Abstract Doc Link 2436181 Disease Relevance 0.76 Pain Relevance 0.42
Noxious stimulation increases glutamate and arginine in the periaqueductal gray matter in rats: a microdialysis study.
Positive_regulation (increases) of periaqueductal gray in gray matter associated with pain, glutamate and central grey
15) Confidence 0.00 Published 2000 Journal Pain Section Title Doc Link 10924806 Disease Relevance 0.65 Pain Relevance 0.59
Blockade of nociceptive inhibition of plasma extravasation by opioid stimulation of the periaqueductal gray and its interaction with vagus-induced inhibition in the rat.
Positive_regulation (stimulation) of periaqueductal gray in plasma associated with nociception, qutenza, central grey and opioid
16) Confidence 0.00 Published 2003 Journal Neuroscience Section Title Doc Link 12809707 Disease Relevance 0.76 Pain Relevance 0.69
Furthermore, the effects of electrical stimulation of the periaqueductal gray are blocked by microinjection of a 5-HT antagonist into the n. raphe magnus.
Positive_regulation (stimulation) of periaqueductal gray associated with raphe magnus, antagonist and central grey
17) Confidence 0.00 Published 1984 Journal Neuropharmacology Section Abstract Doc Link 6098854 Disease Relevance 0.55 Pain Relevance 0.95
Damage to, or selective depletion of 5-HT from the raphe-spinal 5-HT system has been reported not to alter nociceptive thresholds or the effects of stimulation of the periaqueductal gray.
Positive_regulation (stimulation) of periaqueductal gray in spinal associated with nociception, central grey and raphe
18) Confidence 0.00 Published 1984 Journal Neuropharmacology Section Abstract Doc Link 6098854 Disease Relevance 0.80 Pain Relevance 1.03
Repetitive electrical stimulation of the mesencephalic periaqueductal gray (PAG) inhibited these nociceptive discharges.
Positive_regulation (stimulation) of periaqueductal gray associated with nociception, urological neuroanatomy and central grey
19) Confidence 0.00 Published 1979 Journal Neurosci. Lett. Section Abstract Doc Link 229438 Disease Relevance 0.37 Pain Relevance 0.42
Distraction significantly increased the activation of the cingulo-frontal cortex including the orbitofrontal and perigenual anterior cingulate cortex (ACC), as well as the periaquaeductal gray (PAG) and the posterior thalamus.
Positive_regulation (activation) of periaquaeductal gray in posterior associated with urological neuroanatomy, thalamus and anterior cingulate cortex
20) Confidence 0.00 Published 2004 Journal Pain Section Abstract Doc Link 15157701 Disease Relevance 1.26 Pain Relevance 1.34

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox