INT172616

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Context Info
Confidence 0.06
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 4.25
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HNF4A) nucleoplasm (HNF4A) nucleus (HNF4A)
DNA binding (HNF4A) cytoplasm (HNF4A)
Anatomy Link Frequency
liver 1
muscle 1
SW620 1
HNF4A (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 17 99.98 Very High Very High Very High
aspirin 14 96.64 Very High Very High Very High
Inflammation 26 95.04 Very High Very High Very High
cINOD 29 90.56 High High
antagonist 20 74.00 Quite High
Kinase C 12 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 4 99.70 Very High Very High Very High
Apoptosis 145 99.08 Very High Very High Very High
Colon Cancer 55 95.68 Very High Very High Very High
INFLAMMATION 30 95.04 Very High Very High Very High
Breast Cancer 50 92.56 High High
Metastasis 14 90.96 High High
Cancer 224 90.08 High High
Colorectal Cancer 36 89.40 High High
Thrombosis 1 89.08 High High
Familial Adenomatous Polyposis 17 86.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that sodium butyrate and Trichostatin A (TSA), inducers of G0–G1 cell cycle arrest and apoptosis in the SW620 colonic carcinoma cell line, up-regulate Tcf activity.
Regulation (regulate) of Tcf in SW620 associated with carcinoma and apoptosis
1) Confidence 0.06 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.50 Pain Relevance 0
-catenin/Tcf-responsive genes by modulating Tcf activity without disrupting ?
Regulation (modulating) of Tcf
2) Confidence 0.06 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.98 Pain Relevance 0.58
Biological network analysis revealed that a number of the differentially expressed energy metabolism genes are targets of HNF4-alpha in liver and/or pancreas [25, 37].
Regulation (targets) of HNF4-alpha in liver
3) Confidence 0.04 Published 2008 Journal Genes Nutr Section Body Doc Link PMC2593008 Disease Relevance 0.87 Pain Relevance 0.20
These substrate proteins include the transcriptional activators E2F1-3 (involved in progression through G1/S cell-cycle transition), P53, c-Jun (a transcription factor involved in the response to mitogens), the erythroid Krüppel-like transcription factor (EKLF), the transcriptional coactivator GATA1 that is required for megakaryocyte and erythrocyte differentiation, the muscle-specific differentiation regulator MyoD, the product of the proto-oncogene c-myb, the HMG protein HMGI(Y), the T-cell factor regulated transcription activator TCF (which is downstream of Wnt signaling proteins), hepatocyte nuclear factor HNF-4, the general transcription factors TFIIE?
Regulation (regulated) of TCF in muscle
4) Confidence 0.04 Published 2002 Journal Genome Biol Section Body Doc Link PMC139359 Disease Relevance 0 Pain Relevance 0
Thus, we examined the effect of PLD isoform-selective inhibitor on TCF activity.
Spec (examined) Regulation (effect) of TCF
5) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.10 Pain Relevance 0
All the categories in this cluster revolve around regulation of transcription.
Regulation (regulation) of transcription
6) Confidence 0.03 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2587479 Disease Relevance 0 Pain Relevance 0
Such small-scale changes on transcription factors in turn can introduce large-scale transcriptome-level changes via downstream target genes.
Regulation (changes) of transcription
7) Confidence 0.01 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2587479 Disease Relevance 0 Pain Relevance 0
The receptor dimers bind to retinoic acid response elements or retinoid X response elements in the promoter sequences of target genes, and they modulate gene transcription [23-25].
Regulation (modulate) of transcription
8) Confidence 0.01 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2949655 Disease Relevance 0.94 Pain Relevance 0
Second, the reduced enzyme activities measured in the previous studies could be, at least in part, based on factors acting is trans; e.g. mutations affecting the activity of transcription factors controlling the expression of the TPI enzyme.
Regulation (affecting) of transcription
9) Confidence 0.00 Published 2008 Journal BMC Genet Section Body Doc Link PMC2424074 Disease Relevance 0.24 Pain Relevance 0
agonists modulate the activity of several transcription
Regulation (modulate) of transcription associated with agonist
10) Confidence 0.00 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 0.63 Pain Relevance 0.23

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