INT172617

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Context Info
Confidence 0.33
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.47
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HAT1) nucleolus (HAT1) nucleus (HAT1)
transferase activity, transferring acyl groups (HAT1) cytoplasm (HAT1)
Anatomy Link Frequency
brain 1
HAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 36 99.36 Very High Very High Very High
rheumatoid arthritis 74 98.56 Very High Very High Very High
cytokine 21 95.04 Very High Very High Very High
Inflammation 39 93.04 High High
corticosteroid 6 75.12 Quite High
dexamethasone 1 73.12 Quite High
Inflammatory mediators 2 68.16 Quite High
Potency 4 42.56 Quite Low
cINOD 5 31.84 Quite Low
agonist 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
African Trypanosomiasis 232 100.00 Very High Very High Very High
Disease 174 99.78 Very High Very High Very High
Repression 3 99.40 Very High Very High Very High
Frailty 38 99.36 Very High Very High Very High
Asthma 53 99.28 Very High Very High Very High
Recurrence 2 98.78 Very High Very High Very High
Rheumatoid Arthritis 74 98.56 Very High Very High Very High
Infection 67 98.54 Very High Very High Very High
INFLAMMATION 49 93.04 High High
Cancer 9 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our study also observed that the high disease burden of HAT was largely attributed to high levels of disease under-reporting in Urambo, which suggested that for every reported case of HAT nine went un-reported [18].
Positive_regulation (attributed) of HAT associated with african trypanosomiasis and disease
1) Confidence 0.33 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970539 Disease Relevance 0.96 Pain Relevance 0
The public health burden for HAT has been estimated at 1,609,000 DALYs with 50,000 annual deaths [9], although there are many methodological and data issues that deserve greater consideration when making such estimates for HAT [10].
Positive_regulation (estimates) of HAT associated with african trypanosomiasis
2) Confidence 0.29 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970539 Disease Relevance 1.68 Pain Relevance 0
The level of HAT activity is elevated in patients with asthma, and HDAC activity is reduced in bronchial biopsies, which may contribute to local proinflammatory cytokine production.20 Glucocorticoids switch off inflammatory genes in those with asthma by directly inhibiting HAT activity and by recruiting HDAC2 to activate nuclear factor ?
Positive_regulation (elevated) of HAT associated with asthma, inflammation and cytokine
3) Confidence 0.08 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2892049 Disease Relevance 0.61 Pain Relevance 0.20
While the predictive value of these murine models in terms of the potential for curing stage 2 patients is not fully established (only melarsoprol cures both), the demonstration that a drug candidate can clear systemic trypanosome infections in both the acute and chronic model, as well as clearing the brain infection (no relapse in the chronic model), is widely considered as the critical feature for a stage 2 HAT drug candidate.
Positive_regulation (feature) of HAT in brain associated with african trypanosomiasis, recurrence and infection
4) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3006138 Disease Relevance 0.73 Pain Relevance 0
Recent studies on the balance of HAT and HDAC activity in human RA synovial tissue indicated that HDAC activity was significantly decreased in RA synovial tissue compared to osteoarthritis (OA) and normal tissues, thus HDAC/HAT might be strongly shifted toward histone hyperacetylation in RA patients [12].
Positive_regulation (shifted) of HAT associated with rheumatoid arthritis and osteoarthritis
5) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 0.99 Pain Relevance 0.33
APOL1 lyses trypanosomes except the ones which are causing HAT [102].
Neg (except) Positive_regulation (causing) of HAT associated with african trypanosomiasis
6) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.50 Pain Relevance 0
For example, the HAT activity of CBP is stimulated at the G1-S phase boundary of the cell cycle, and hormone-induced acetylation of ACTR represses nuclear receptor function.
Positive_regulation (stimulated) of HAT
7) Confidence 0.01 Published 2002 Journal Genome Biol Section Body Doc Link PMC139359 Disease Relevance 0 Pain Relevance 0

General Comments

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