INT17262

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Context Info
Confidence 0.59
First Reported 1987
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 17
Total Number 21
Disease Relevance 15.14
Pain Relevance 6.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
molecular_function (Plat) cytoplasm (Plat)
Anatomy Link Frequency
brain 3
plasma 2
chest 2
sciatic nerve 1
neurons 1
Plat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain score 3 99.86 Very High Very High Very High
Angina 17 99.74 Very High Very High Very High
cva 10 99.64 Very High Very High Very High
intrathecal 3 99.50 Very High Very High Very High
nMDA receptor 3 99.12 Very High Very High Very High
ischemia 109 98.60 Very High Very High Very High
Sciatic nerve 3 98.28 Very High Very High Very High
Neuropathic pain 5 98.08 Very High Very High Very High
allodynia 2 97.96 Very High Very High Very High
Pain 13 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Brain Injury 10 100.00 Very High Very High Very High
Coronary Artery Disease 28 99.84 Very High Very High Very High
Hyperlipidemia 5 99.76 Very High Very High Very High
Myocardial Infarction 45 99.74 Very High Very High Very High
Angina 6 99.74 Very High Very High Very High
Cv General 3 Under Development 8 99.64 Very High Very High Very High
Stroke 289 98.96 Very High Very High Very High
Nicotine Addiction 64 98.96 Very High Very High Very High
Pressure And Volume Under Development 26 98.92 Very High Very High Very High
Body Weight 4 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also showed that inhibition of the tissue type plasminogen activator (tPA-stop/PAI-1) significantly interfered with the activity-induced increase in perforated synapses.
Negative_regulation (inhibition) of tissue type plasminogen activator in synapses
1) Confidence 0.59 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10594650 Disease Relevance 0 Pain Relevance 0.35
These potentially identify new targets to reduce tPA related complications in ischemic stroke and perhaps extend the therapeutic window of tPA.


Negative_regulation (reduce) of tPA associated with stroke
2) Confidence 0.58 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 0.48 Pain Relevance 0.03
Intrathecal injection of a specific inhibitor of tPA decreased electrical stimulation-induced Fos expression in dorsal horn neurons following axotomy, and also prevented the development of thermal hyperalgesia following partial sciatic nerve ligation.
Negative_regulation (inhibitor) of tPA in neurons associated with thermal hyperalgesia, sciatic nerve, dorsal horn neuron and intrathecal
3) Confidence 0.57 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 14750967 Disease Relevance 0.56 Pain Relevance 0.96
Increased levels of an endogenous inhibitor of tissue-plasminogen activator (t-PA) have been thought to relate to the genesis of acute myocardial ischemia.
Negative_regulation (inhibitor) of t-PA associated with coronary artery disease and ischemia
4) Confidence 0.52 Published 1987 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 3100598 Disease Relevance 0.60 Pain Relevance 0.21
Intrathecal and continuous administration of tPA inhibitor, tPA-STOP, suppressed root ligation-induced mechanical allodynia in a dose-dependent manner during an early stage of injury (0-4 days).
Negative_regulation (inhibitor) of tPA associated with allodynia, injury and intrathecal
5) Confidence 0.43 Published 2007 Journal Glia Section Abstract Doc Link 17299772 Disease Relevance 1.22 Pain Relevance 1.03
Intrathecal and continuous administration of tPA inhibitor, tPA-STOP, suppressed root ligation-induced mechanical allodynia in a dose-dependent manner during an early stage of injury (0-4 days).
Negative_regulation (inhibitor) of tPA associated with allodynia, injury and intrathecal
6) Confidence 0.43 Published 2007 Journal Glia Section Abstract Doc Link 17299772 Disease Relevance 1.22 Pain Relevance 1.03
A number of the identified tPA regulated genes in our study are associated with neutrophils.
Negative_regulation (number) of tPA in neutrophils
7) Confidence 0.42 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 0.62 Pain Relevance 0.11
Mast cell stabilization with cromoglycate reduces tPA related brain hemorrhage, brain edema and neutrophil infiltration [15].
Negative_regulation (reduces) of tPA in brain associated with pressure and volume under development and cva
8) Confidence 0.42 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 0.73 Pain Relevance 0.12
To detect the protective effect of delayed postconditioning on the exaggerative effect of t-PA on brain injury, rats were randomly assigned into 4 groups: control ischemia; ischemia plus t-PA; ischemia plus postconditioning; ischemia plus both t-PA and postconditioning.
Negative_regulation (effect) of t-PA in brain associated with ischemia and brain injury
9) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588536 Disease Relevance 0.95 Pain Relevance 0.26
Nonetheless, this study does not suggest a pathogenic role of t-PA inhibitor in coronary atherosclerosis.
Negative_regulation (inhibitor) of t-PA associated with coronary artery disease
10) Confidence 0.39 Published 1987 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 3100598 Disease Relevance 0.98 Pain Relevance 0.15
To examine the role of the rapid inhibitor of t-PA, plasma samples were analyzed from 75 patients with chest pain syndrome undergoing coronary angiography (mean age 57 years), 24 patients with clinically documented coronary artery disease (unstable angina, positive exercise stress test or previous history of myocardial infarction; mean age 58 years) and 15 young normal subjects (mean age 26 years).
Spec (examine) Negative_regulation (inhibitor) of t-PA in chest associated with stress, complex regional pain syndromes, angina, coronary artery disease and myocardial infarction
11) Confidence 0.39 Published 1987 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 3100598 Disease Relevance 0.70 Pain Relevance 0.24
Association of high levels of inhibitor of t-PA with hypertriglyceridemia may be of importance in the development of coronary thrombosis, especially in elderly patients.
Negative_regulation (inhibitor) of t-PA associated with thrombosis related under development and hyperlipidemia
12) Confidence 0.39 Published 1987 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 3100598 Disease Relevance 1.06 Pain Relevance 0.17
t-PA exacerbated-brain injury was inhibited by delayed postconditioning
Negative_regulation (inhibited) of t-PA in brain associated with brain injury
13) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588536 Disease Relevance 0.81 Pain Relevance 0.14
The most marked effect of tissue plasminogen activator was observed in the chest pain score being reduced by 43% in the tissue plasminogen activator group as compared with placebo.
Negative_regulation (reduced) of tissue plasminogen in chest associated with angina and pain score
14) Confidence 0.36 Published 1993 Journal Int. J. Cardiol. Section Abstract Doc Link 8282435 Disease Relevance 0.58 Pain Relevance 0.78
Mortality trials have subsequently demonstrated that agents such as recombinant tissue plasminogen activator, streptokinase, and anisoylated plasminogen streptokinase activator complex remarkably reduce early mortality rates among patients with acute myocardial infarction when treatment is instituted within the first 6 hours of infarction.
Negative_regulation (reduce) of tissue plasminogen activator associated with infarction and myocardial infarction
15) Confidence 0.18 Published 1991 Journal Heart Lung Section Abstract Doc Link 1894538 Disease Relevance 1.20 Pain Relevance 0.17
Here we examined whether the plasminogen activator inhibitor-1 and -2 (PAI-1 and PAI-2) mRNA, endogenous inhibitors of tPA and uPA, are induced in the DRG following sciatic nerve transection.
Spec (whether) Negative_regulation (inhibitors) of tPA in sciatic nerve associated with sciatic nerve
16) Confidence 0.06 Published 2005 Journal Neuroscience Section Abstract Doc Link 15780477 Disease Relevance 0.40 Pain Relevance 0.22
Endothelial function improved progressively and C-reactive protein, P-selectin, and tissue plasminogen activator inhibitor levels decreased, but there was no decrease in exercise electrocardiographic ischemia.
Negative_regulation (decreased) of tissue plasminogen activator associated with ischemia
17) Confidence 0.04 Published 2003 Journal Am. J. Cardiol. Section Abstract Doc Link 14609594 Disease Relevance 0.42 Pain Relevance 0.29
Protein C inhibits factors Va and VIIIa in the coagulation cascade and inactivates tissue plasminogen activator inhibitor, thus maintaining hemostasis.
Negative_regulation (inactivates) of tissue plasminogen activator
18) Confidence 0.02 Published 2003 Journal J Extra Corpor Technol Section Abstract Doc Link 12680495 Disease Relevance 0.24 Pain Relevance 0
Protein C inhibits factors Va and VIIIa in the coagulation cascade and inactivates tissue plasminogen activator inhibitor, thus maintaining hemostasis.
Negative_regulation (inhibitor) of tissue plasminogen activator
19) Confidence 0.02 Published 2003 Journal J Extra Corpor Technol Section Abstract Doc Link 12680495 Disease Relevance 0.24 Pain Relevance 0
Decreased plasma tissue plasminogen activator activity was observed in smokers.
Negative_regulation (Decreased) of plasma tissue plasminogen activator in plasma associated with nicotine addiction
20) Confidence 0.01 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2844977 Disease Relevance 1.62 Pain Relevance 0.04

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