INT172622

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Context Info
Confidence 0.65
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.56
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (EP300) transferase activity, transferring acyl groups (EP300) DNA binding (EP300)
cytoplasm (EP300) nucleolus (EP300) nucleus (EP300)
Anatomy Link Frequency
neuronal 1
EP300 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 141 99.20 Very High Very High Very High
cocaine 185 98.96 Very High Very High Very High
addiction 160 94.52 High High
drug abuse 46 89.20 High High
Nicotine 59 70.04 Quite High
imagery 42 64.32 Quite High
cannabis 22 61.04 Quite High
opiate 60 60.12 Quite High
methadone 57 59.36 Quite High
Opioid 37 58.36 Quite High
Disease Link Frequency Relevance Heat
Cognitive Disorder 119 98.04 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 284 98.00 Very High Very High Very High
Drug Dependence 279 94.52 High High
Sleep Disorders 113 89.44 High High
Opiate Addiction 36 87.40 High High
Congenital Anomalies 30 77.52 Quite High
Psychosis 4 58.48 Quite High
INFLAMMATION 10 49.88 Quite Low
Disease 19 48.76 Quite Low
Nicotine Addiction 25 47.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The clinical relevance of altered P300 amplitudes follows the relevance of the P300 as an indicator of neuronal activity related to cognitive processing [32-34].
Localization (relevance) of P300 in neuronal associated with cognitive disorder
1) Confidence 0.65 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2198909 Disease Relevance 0.15 Pain Relevance 0.44
C/EBP increases the phosphorylation of p300, which in turn alters its nuclear localization and increases its activity [184].
Localization (localization) of p300
2) Confidence 0.23 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.51 Pain Relevance 0.03
C/EBP increases the phosphorylation of p300, which in turn alters its nuclear localization and increases its activity [184].
Localization (localization) of p300
3) Confidence 0.23 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.51 Pain Relevance 0.03
Both systems are based on P300, a potential evoked by an awaited infrequent stimulus.
Localization (based) of P300
4) Confidence 0.22 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2944670 Disease Relevance 0 Pain Relevance 0
This conclusion is further supported by the observation that both N1 and P300 are influenced by noradrenergic, dopaminergic, and cholinergic systems, i.e., systems which are known to mediate attention and arousal [81, 82].


Localization (influenced) of P300
5) Confidence 0.15 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.24 Pain Relevance 0.03
This study also demonstrated that continued abstinence from heroin and from cocaine and alcohol is also associated with a trend toward normalization of the P300.
Localization (normalization) of P300 associated with alcohol and cocaine
6) Confidence 0.10 Published 2008 Journal Appl Psychophysiol Biofeedback Section Body Doc Link PMC2259255 Disease Relevance 0.46 Pain Relevance 0.51
Continued abstinence from heroin, cocaine, and alcohol was shown to be associated with a trend toward P300 normalization.
Localization (normalization) of P300 associated with alcohol and cocaine
7) Confidence 0.10 Published 2008 Journal Appl Psychophysiol Biofeedback Section Body Doc Link PMC2259255 Disease Relevance 0.69 Pain Relevance 0.69
Both p300 and CBP can mediate acetylation of Rch1 and importin-?
Localization (importin) of p300
8) Confidence 0.09 Published 2002 Journal Genome Biol Section Body Doc Link PMC139359 Disease Relevance 0 Pain Relevance 0

General Comments

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