INT172624

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Context Info
Confidence 0.22
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.05
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NCOA3) small molecule metabolic process (NCOA3) Golgi apparatus (NCOA3)
nucleolus (NCOA3) nucleus (NCOA3) transferase activity, transferring acyl groups (NCOA3)
Anatomy Link Frequency
platelets 1
nucleus 1
NCOA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 3 65.48 Quite High
addiction 3 50.00 Quite Low
Gabapentin 1 27.92 Quite Low
agonist 4 18.08 Low Low
Cholecystokinin 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 56 97.08 Very High Very High Very High
Targeted Disruption 1 93.68 High High
Avian Sarcoma 1 90.88 High High
Breast Cancer 43 81.52 Quite High
Apoptosis 14 80.72 Quite High
Carcinoma 3 70.36 Quite High
Advanced Or Metastatic Breast Cancer 3 66.96 Quite High
Ductal Carcinoma 1 23.00 Low Low
Cardiovascular Disease 12 5.00 Very Low Very Low Very Low
Recurrence 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, (no. 22) NCOA3 (pCIP/SRC3) is associated by an unknown mechanism with a decrease in circulating platelets in Src3(?
SRC3 Binding (associated) of in platelets
1) Confidence 0.22 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958630 Disease Relevance 0.27 Pain Relevance 0.03
None of the variant proteins interacted constitutively with coactivators of the p160 family (SRC-1, TIF-2 and ACTR) in this assay.
ACTR Binding (interacted) of
2) Confidence 0.12 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0
Osborne and colleagues [44] reported an association between the ER coactivator AIB1 (SRC-3) and tamoxifen resistance, particularly in patients with HER-2-positive tumors treated with tamoxifen.
SRC-3 Binding (association) of associated with cancer
3) Confidence 0.06 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400674 Disease Relevance 0.78 Pain Relevance 0
Acetylation of transcription factors can alter their ability to bind DNA (in the cases of E2F1, p53, EKLF, GATA1, and HNF-4), to interact with other proteins (c-Jun, TCF, ACTR, and HNF-4), or to remain in the nucleus (HNF-4).
ACTR Binding (interact) of in nucleus
4) Confidence 0.02 Published 2002 Journal Genome Biol Section Body Doc Link PMC139359 Disease Relevance 0 Pain Relevance 0

General Comments

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