INT172625

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Context Info
Confidence 0.35
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 9.21
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HAT1) nucleolus (HAT1) nucleus (HAT1)
transferase activity, transferring acyl groups (HAT1) cytoplasm (HAT1)
Anatomy Link Frequency
reservoirs 1
HAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 1 90.08 High High
pruritus 1 88.88 High High
headache 6 87.08 High High
Central nervous system 4 67.88 Quite High
Potency 10 54.00 Quite High
Bioavailability 10 40.32 Quite Low
intrathecal 1 33.32 Quite Low
cytokine 15 32.80 Quite Low
Inflammation 11 30.08 Quite Low
depression 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
African Trypanosomiasis 511 100.00 Very High Very High Very High
Disease 336 99.28 Very High Very High Very High
Cancer 27 96.16 Very High Very High Very High
Infection 94 90.72 High High
Angina 1 90.08 High High
Pruritus 1 88.88 High High
Diarrhoea 1 87.48 High High
Headache 5 87.08 High High
Fever 10 86.68 High High
Eczema 1 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some authors [7], [8] have notably argued that the burden of the rhodesiense form of HAT can be significantly reduced by treating domestic livestock reservoirs as this can play an important role in controlling HAT in humans.
Regulation (controlling) of HAT in reservoirs associated with african trypanosomiasis
1) Confidence 0.35 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970539 Disease Relevance 1.62 Pain Relevance 0
One of the major control challenges for HAT is the resurgence of both the gambiense and rhodesiense forms of the disease, which has been observed for rhodesiense in Tanzania as well as in many other disease endemic countries of sub-Saharan Africa.
Regulation (control) of HAT associated with african trypanosomiasis and disease
2) Confidence 0.30 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970539 Disease Relevance 0.53 Pain Relevance 0
With only six years remaining to the year targeted by World Health Organization (WHO) for HAT elimination, the disease situation is still unclear in about one third of the countries where it is endemic [11].
Regulation (targeted) of HAT associated with african trypanosomiasis and disease
3) Confidence 0.30 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970539 Disease Relevance 1.61 Pain Relevance 0
Some evidence indicates that the activity of HATs is regulated by proliferation and differentiation signals [23], via phosphorylation or hormonal signaling.
Regulation (regulated) of HAT
4) Confidence 0.26 Published 2002 Journal Genome Biol Section Body Doc Link PMC139359 Disease Relevance 0 Pain Relevance 0
Finally, FIND will collaborate with WHO, other agencies and national programmes to demonstrate the impact that use of these products has on HAT control.
Regulation (control) of HAT associated with african trypanosomiasis
5) Confidence 0.21 Published 2006 Journal Kinetoplastid Biol Dis Section Body Doc Link PMC1464096 Disease Relevance 0.35 Pain Relevance 0.03
Accurate estimates of incidence and effective control of HAT, especially of the chronic West and Central African form caused by T. b. gambiense, depend on active surveillance which is expensive and requires a high level of organization.
Regulation (control) of HAT associated with african trypanosomiasis
6) Confidence 0.18 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970539 Disease Relevance 1.56 Pain Relevance 0
Of the drugs currently in clinical use (Table 1), only melarsoprol is effective in this experimental stage 2 HAT model.


Regulation (effective) of HAT associated with african trypanosomiasis
7) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3006138 Disease Relevance 0.45 Pain Relevance 0.03
To change the dynamics of HAT control and access more patients while improving their case-management, a safe, effective, affordable, and easy-to-use (short course, preferably oral) treatment is urgently needed.
Regulation (control) of HAT associated with african trypanosomiasis
8) Confidence 0.02 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3006138 Disease Relevance 0.77 Pain Relevance 0
If fexinidazole successfully completes clinical development, it will represent a real breakthrough for the control of HAT in rural Africa for several reasons.
Regulation (control) of HAT associated with african trypanosomiasis
9) Confidence 0.02 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3006138 Disease Relevance 0.44 Pain Relevance 0
Drug resistance in trypanosomes appears to be increasing in the field and is now hindering efforts to control the HAT.
Regulation (control) of HAT associated with african trypanosomiasis
10) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 1.68 Pain Relevance 0.22
Moreover, given that the balance of acetylation and deacetylation, under the control of HAT and HDAC, is not restricted to histones [29], it can be hypothesized that VPA, like other HDACi, could modulate molecular activity in addition to transcription.
Regulation (control) of HAT
11) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.19 Pain Relevance 0

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