INT172630

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Context Info
Confidence 0.05
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 19
Disease Relevance 7.78
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HNF4A) nucleoplasm (HNF4A) nucleus (HNF4A)
DNA binding (HNF4A) cytoplasm (HNF4A)
Anatomy Link Frequency
nucleus 3
T-cell 1
HNF4A (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 63 94.52 High High
Crohn's disease 160 93.84 High High
antagonist 71 93.84 High High
cINOD 123 88.44 High High
fibrosis 2 82.24 Quite High
ischemia 4 80.44 Quite High
Nicotine 14 66.36 Quite High
Inflammation 46 49.36 Quite Low
Pain 1 42.52 Quite Low
Kinase C 54 28.24 Quite Low
Disease Link Frequency Relevance Heat
Cancer 853 98.76 Very High Very High Very High
Colorectal Cancer 162 97.52 Very High Very High Very High
Nicotine Addiction 194 94.76 High High
Disease 345 93.84 High High
Colon Cancer 226 93.80 High High
Death 18 91.60 High High
Metastasis 47 88.96 High High
Apoptosis 230 88.08 High High
Leukemia 70 85.00 Quite High
Familial Adenomatous Polyposis 75 84.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin/Tcf complex formation [96].
Tcf Binding (formation) of
1) Confidence 0.05 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.91 Pain Relevance 0.50
-catenin/Tcf interaction.
Tcf Binding (interaction) of
2) Confidence 0.05 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.54 Pain Relevance 0.05
-catenin/Tcf complex, drives these cells out of the cycle [164].
Tcf Binding (complex) of
3) Confidence 0.05 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.62 Pain Relevance 0
Although Tcf/Lef directly bind to DNA through their HMG domains, they are incapable of independently activating gene transcription [18]. ?
Tcf Binding (bind) of
4) Confidence 0.05 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0 Pain Relevance 0
-catenin/Tcf complex is thus an attractive target for anti-cancer drugs, but any such compound must selectively interfere with the complex without disrupting other essential interactions of ?
Tcf Binding (complex) of associated with cancer
5) Confidence 0.05 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.65 Pain Relevance 0
-catenin is then able to localize to the nucleus [15], form a complex with Tcf/Lef transcription factors and co-activators such as (CREB Binding Protein, CBP) [16, 17] and induce the expression of downstream target genes (see http://www.stanford.edu/~rnusse/wntwindow.html).
Tcf Binding (complex) of in nucleus
6) Confidence 0.05 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0 Pain Relevance 0
-catenin/Tcf interaction depends on a detailed understanding of the interactions of ?
Tcf Binding (interaction) of
7) Confidence 0.05 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.65 Pain Relevance 0
-catenin/Tcf complex is an enticing target for rational design of cancer therapeutics, but the promiscuity of ?
Tcf Binding (complex) of associated with cancer
8) Confidence 0.05 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.40 Pain Relevance 0.05
The interaction between Tcf transcription factors and ?
Tcf Binding (interaction) of
9) Confidence 0.05 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.67 Pain Relevance 0
-catenin/TCF interaction in other aspects.
TCF Binding (interaction) of
10) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.13 Pain Relevance 0.08
Acetylation of transcription factors can alter their ability to bind DNA (in the cases of E2F1, p53, EKLF, GATA1, and HNF-4), to interact with other proteins (c-Jun, TCF, ACTR, and HNF-4), or to remain in the nucleus (HNF-4).
TCF Binding (interact) of in nucleus
11) Confidence 0.03 Published 2002 Journal Genome Biol Section Body Doc Link PMC139359 Disease Relevance 0 Pain Relevance 0
Acetylation of transcription factors can alter their ability to bind DNA (in the cases of E2F1, p53, EKLF, GATA1, and HNF-4), to interact with other proteins (c-Jun, TCF, ACTR, and HNF-4), or to remain in the nucleus (HNF-4).
HNF-4 Binding (interact) of in nucleus
12) Confidence 0.03 Published 2002 Journal Genome Biol Section Body Doc Link PMC139359 Disease Relevance 0 Pain Relevance 0
-catenin/TCF transcriptional activity by increasing formation of the ?
TCF Binding (activity) of
13) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.25 Pain Relevance 0
Moreover, we also found that TCF binding elements existed in the promoter region of PLD1 gene and PLD1 also promotes Wnt signaling through TCF4 transcriptional activation.
TCF Binding (binding) of
14) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.30 Pain Relevance 0
-catenin/TCF complex is required for proper transcriptional activity, we examined the possibility that Wnt-induced PLDs upregulation could enhance the association of ?
TCF Spec (examined) Binding (complex) of
15) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.08 Pain Relevance 0
RNF138, initially named NARF (NLK-associated RING finger protein) [33], has been shown to ubiquitinate TCF (T-cell factor)/LEF (lymphoid enhancer factor) proteins, which leads to their degradation and hence inhibits Wnt signalling [34].
TCF Binding (leads) of in T-cell
16) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2708910 Disease Relevance 1.06 Pain Relevance 0.34
-catenin pathway, which ultimately results in an activation of the DNA bound TCF/LEF transcription factors.
TCF Binding (bound) of
17) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2708910 Disease Relevance 0.78 Pain Relevance 0.21
Nuclear receptors are ligand-dependent transcription factors, which regulate gene expression by binding to HREs (hormone response elements) located in regulatory regions of target genes (12).
transcription Binding (binding) of
18) Confidence 0.01 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
hours of troglitazone treatment while DNA binding by Tcf-4, a transcription
transcription Binding (binding) of
19) Confidence 0.00 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 0.74 Pain Relevance 0

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