INT17268

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Context Info
Confidence 0.78
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 11.71
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PLG) extracellular space (PLG) extracellular region (PLG)
plasma membrane (PLG)
Anatomy Link Frequency
endothelial cells 2
colon 2
extracellular matrix 2
plasma 1
blood 1
PLG (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 5 98.12 Very High Very High Very High
rheumatoid arthritis 122 96.32 Very High Very High Very High
Pain 20 93.24 High High
headache 1 85.32 High High
Inflammation 88 85.16 High High
depression 25 84.48 Quite High
metalloproteinase 13 82.56 Quite High
cytokine 25 79.44 Quite High
cINOD 4 69.68 Quite High
aspirin 1 67.48 Quite High
Disease Link Frequency Relevance Heat
Metastasis 100 99.92 Very High Very High Very High
Colon Cancer 46 99.84 Very High Very High Very High
Cancer 238 99.76 Very High Very High Very High
Obesity 52 99.14 Very High Very High Very High
Skin Cancer 204 98.96 Very High Very High Very High
Angina 5 98.12 Very High Very High Very High
Critical Illness 18 97.12 Very High Very High Very High
Osteoarthritis 18 96.72 Very High Very High Very High
Rheumatoid Arthritis 122 96.32 Very High Very High Very High
Prostate Cancer 1 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, tetranectin exhibited a similar IHC staining pattern as plasminogen in colon cancer and co-localized with plasminogen/plasmin at the invasive front of cutaneous melanoma lesions, indicating a coordinated role of these proteins in the invasive process [57,58].
Localization (localized) of plasmin in colon associated with colon cancer and skin cancer
1) Confidence 0.78 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 1.38 Pain Relevance 0
Other enzymes such as heparanase and plasmin are produced and secreted from endothelial cells.
Localization (secreted) of plasmin in endothelial cells
2) Confidence 0.78 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.86 Pain Relevance 0.58
In vitro, the fungal enzyme preparation stimulated elastase release from isolated neutrophils and eliminated plasmatic inhibitors and plasminogen in normal plasma and whole blood.
Localization (release) of plasminogen in blood
3) Confidence 0.53 Published 1989 Journal Toxicology Section Abstract Doc Link 2469140 Disease Relevance 0.77 Pain Relevance 0.09
In addition, tetranectin exhibited a similar IHC staining pattern as plasminogen in colon cancer and co-localized with plasminogen/plasmin at the invasive front of cutaneous melanoma lesions, indicating a coordinated role of these proteins in the invasive process [57,58].
Localization (localized) of plasminogen in colon associated with colon cancer and skin cancer
4) Confidence 0.32 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 1.38 Pain Relevance 0
Plasminogen activators released from cancer cells may catalyze the proteolytic conversion of the inactive zymogen plasminogen to the active protease plasmin, which in turn catalyzes degradation of proteins in basement membranes and extracellular matrix (ECM) and thus facilitates cancer cell invasion into the surrounding tissue.
Localization (released) of Plasminogen in basement membranes associated with cancer
5) Confidence 0.28 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 0.98 Pain Relevance 0
Adipose tissue is now regarded as an endocrine organ and secretes several adipokines, such as adiponectin, resistin, plasminogen activating inhibitor-1 (PAI-1) and retinol binding protein 4 (RBP4) [29]–[31].
Localization (secretes) of plasminogen in endocrine organ associated with obesity
6) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148106 Disease Relevance 1.35 Pain Relevance 0.36
Plasminogen activators released from cancer cells may catalyze the proteolytic conversion of the inactive zymogen plasminogen to the active protease plasmin, which in turn catalyzes degradation of proteins in basement membranes and extracellular matrix (ECM) and thus facilitates cancer cell invasion into the surrounding tissue.
Localization (released) of Plasminogen in extracellular matrix associated with cancer
7) Confidence 0.10 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 0.98 Pain Relevance 0
Patients on extracorporeal circuits may also experience a marked activation of fibrinolysis due to release of plasminogen activators from endothelial cells.
Localization (release) of plasminogen in endothelial cells
8) Confidence 0.10 Published 2006 Journal Crit Care Section Body Doc Link PMC1750988 Disease Relevance 1.14 Pain Relevance 0.17
Staphylokinase (SAK) is a secreted protein that binds and activates surface-bound plasminogen into plasmin, which may enhance bacterial invasion through host tissues.
Localization (secreted) of plasminogen
9) Confidence 0.04 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.07 Pain Relevance 0
They did not diminish plasminogen activator release during exercise in patients with pre-exercise unstable angina.
Localization (release) of plasminogen associated with angina
10) Confidence 0.04 Published 1991 Journal Kardiologiia Section Abstract Doc Link 1895656 Disease Relevance 0.54 Pain Relevance 0.45
Measurements were performed for (1) platelet surface activation, assessing flow cytometric expression of activated integrin alpha(IIb)beta(3) receptor (GPIIb/IIIa, CD41a) and P-selectin (CD62p); (2) platelet and erythrocyte surface procoagulant activities, measuring flow cytometric binding of activated factor (FVa) and annexin V; (3) plasma levels of platelet-specific secreted proteins platelet factor 4 (PF4) and beta-thromboglobulin (betaTG); (4) plasma markers of thrombin generation, prothrombin activation fragment (F(1.2)), and thrombin: antithrombin complex (TAT); and (5) plasma markers of fibrinolysis, D -dimer, and plasmin:antiplasmin complex (PAP).
Localization (assessing) of plasmin in plasma
11) Confidence 0.03 Published 2001 Journal J. Lab. Clin. Med. Section Abstract Doc Link 11385360 Disease Relevance 0.73 Pain Relevance 0.32
For example when the streptococcal spreading factor known as streptokinase (SK) combines with host plasminogen, plasmin is released.
Localization (released) of plasminogen
12) Confidence 0.01 Published 2006 Journal J Transl Med Section Body Doc Link PMC1479838 Disease Relevance 1.51 Pain Relevance 0.09

General Comments

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