INT1727

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Context Info
Confidence 0.74
First Reported 1979
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 22
Total Number 24
Disease Relevance 4.28
Pain Relevance 3.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cndp2) peptidase activity (Cndp2) cytoplasm (Cndp2)
Anatomy Link Frequency
brain 2
bridge 2
skin 2
Cleavage 1
internal 1
Cndp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 6 100.00 Very High Very High Very High
Hippocampus 1 97.20 Very High Very High Very High
opiate 7 96.72 Very High Very High Very High
Inflammation 39 95.00 High High
headache 8 93.92 High High
Analgesic 46 93.00 High High
Opioid 29 92.44 High High
analgesia 22 90.20 High High
Antinociceptive 22 87.36 High High
narcan 21 85.96 High High
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 264 99.36 Very High Very High Very High
Neuroma 79 99.24 Very High Very High Very High
INFLAMMATION 44 95.00 High High
Attention Deficit Hyperactivity Disorder 7 94.92 High High
Headache 8 93.92 High High
Disease 63 75.60 Quite High
Friedreich Ataxia 53 59.96 Quite High
Coronary Heart Disease 6 52.80 Quite High
Cancer 11 49.36 Quite Low
Necrosis 3 48.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expressed and purified PEP-1-BoNT/A fusion proteins were efficiently transduced into cells in a time- and dose-dependent manner when added exogenously in a culture medium.
Gene_expression (expressed) of PEP-1-BoNT
1) Confidence 0.74 Published 2006 Journal J. Biochem. Mol. Biol. Section Abstract Doc Link 17002886 Disease Relevance 0.18 Pain Relevance 0.18
In this study, a BoNT/A gene were fused with PEP-1 peptide in a bacterial expression vector to produce a genetic in-frame PEP-1-BoNT/A fusion protein.
Gene_expression (produce) of PEP-1-BoNT
2) Confidence 0.74 Published 2006 Journal J. Biochem. Mol. Biol. Section Abstract Doc Link 17002886 Disease Relevance 0.18 Pain Relevance 0.18
Cn2 also produced both actions in mouse Purkinje cells.
Gene_expression (produced) of Cn2 in Purkinje cells
3) Confidence 0.67 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16702217 Disease Relevance 0 Pain Relevance 0.12
Two C. intestinalis (Cin3 and Cin4) genes are seen to cluster with the PHEX group of peptidases indicating a potential recent, gene duplication in Ciona (Figure 2 V).
Gene_expression (group) of peptidase
4) Confidence 0.65 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2259306 Disease Relevance 0 Pain Relevance 0
However, a cysteine bridge between Cys233 and Cys241 of human neprilysin is only present in mammalian neprilysins and no other M13 peptidases (Additional file 2).
Neg (no) Gene_expression (other) of peptidase in bridge
5) Confidence 0.65 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2259306 Disease Relevance 0 Pain Relevance 0
However, a cysteine bridge between Cys233 and Cys241 of human neprilysin is only present in mammalian neprilysins and no other M13 peptidases (Additional file 2).
Neg (no) Gene_expression (present) of peptidase in bridge
6) Confidence 0.65 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2259306 Disease Relevance 0 Pain Relevance 0
Expression, purification and transduction of PEP-1-botulinum neurotoxin type A (PEP-1-BoNT/A) into skin.
Gene_expression (Expression) of PEP-1-BoNT in skin
7) Confidence 0.64 Published 2006 Journal J. Biochem. Mol. Biol. Section Title Doc Link 17002886 Disease Relevance 0.19 Pain Relevance 0.18
The expressed and purified PEP-1-BoNT/A fusion proteins were efficiently transduced into cells in a time- and dose-dependent manner when added exogenously in a culture medium.
Gene_expression (expressed) of PEP-1-BoNT
8) Confidence 0.64 Published 2006 Journal J. Biochem. Mol. Biol. Section Abstract Doc Link 17002886 Disease Relevance 0.18 Pain Relevance 0.18
In this study, a BoNT/A gene were fused with PEP-1 peptide in a bacterial expression vector to produce a genetic in-frame PEP-1-BoNT/A fusion protein.
Gene_expression (produce) of PEP-1-BoNT
9) Confidence 0.64 Published 2006 Journal J. Biochem. Mol. Biol. Section Abstract Doc Link 17002886 Disease Relevance 0.18 Pain Relevance 0.18
In this study, a BoNT/A gene were fused with PEP-1 peptide in a bacterial expression vector to produce a genetic in-frame PEP-1-BoNT/A fusion protein.
Gene_expression (produce) of PEP-1
10) Confidence 0.64 Published 2006 Journal J. Biochem. Mol. Biol. Section Abstract Doc Link 17002886 Disease Relevance 0.18 Pain Relevance 0.19
PSA is a ubiquitous, 100 kDa, Zn2+ metallopeptidase present in high concentrations in the brain (especially in the striatum, the hippocampus and the cerebellum) (16,17).
Gene_expression (present) of peptidase in cerebellum associated with hippocampus
11) Confidence 0.58 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2972693 Disease Relevance 0 Pain Relevance 0.14
Fernandez and Alba (1996) further affirmed the crucial role of endogenous peptidases implicated in the inactivation of NT and NM in the prefrontal cortex by observing the inhibition of intracranial self-stimulation (ICSS) produced by injections of NT and NM into the medial prefrontal cortex of the rat.
Gene_expression (produced) of peptidase in prefrontal
12) Confidence 0.58 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0 Pain Relevance 0.86
Other metabolic or protein synthesis enzymes were identified as aspartyl-tRNA synthetase (two spots), D-3-phosphoglycerate dehydrogenase, prolyl 4-hydroxylase beta polypeptide, alpha-enolase (three spots) and gamma-enolase, all of which were more highly expressed in neuroma, whereas pyruvate kinase isozyme M2, cytosolic non-specific dipeptidase, lactate dehydrogenase B chain and carbonic anhydrase 3 (two spots) were expressed at a lower level.


Gene_expression (expressed) of cytosolic non-specific dipeptidase associated with neuroma
13) Confidence 0.58 Published 2008 Journal Mol Pain Section Body Doc Link PMC2525634 Disease Relevance 0.55 Pain Relevance 0
Expression of neutral endopeptidase activity during clinical and experimental acute lung injury

Background

Gene_expression (Expression) of peptidase in lung associated with adult respiratory distress syndrome
14) Confidence 0.58 Published 2010 Journal Respir Res Section Title Doc Link PMC3009633 Disease Relevance 1.26 Pain Relevance 0.05
Expression, purification and transduction of PEP-1-botulinum neurotoxin type A (PEP-1-BoNT/A) into skin.
Gene_expression (Expression) of PEP-1 in skin
15) Confidence 0.57 Published 2006 Journal J. Biochem. Mol. Biol. Section Title Doc Link 17002886 Disease Relevance 0.18 Pain Relevance 0.18
Regional distribution of a high-affinity enkephalin-degrading peptidase ('enkephalinase') and effects of lesions suggest localization in the vicinity of opiate receptors in brain.
Gene_expression (distribution) of peptidase in brain associated with opiate and enkephalin
16) Confidence 0.56 Published 1979 Journal Neurosci. Lett. Section Title Doc Link 229439 Disease Relevance 0 Pain Relevance 0.71
Cleavage of bovine P2 protein by cyanogen bromide (CNBr) produced peptide fractions CN1, CN2, and CN3 which were isolated by gel filtration chromatography.
Gene_expression (produced) of CN2 in Cleavage
17) Confidence 0.22 Published 1980 Journal J. Neurochem. Section Abstract Doc Link 6161221 Disease Relevance 0 Pain Relevance 0.04
The presence and regulated expression of peptidase activity is a powerful mechanism with the potential to terminate or alter receptor recognition, cell membrane signal transduction, and physiological responses of immune cells to exogenous opioid peptides.
Gene_expression (expression) of peptidase in immune cells associated with opioid
18) Confidence 0.16 Published 1997 Journal J. Leukoc. Biol. Section Abstract Doc Link 9400816 Disease Relevance 0 Pain Relevance 0.09
The mean ± SEM peptidase activity measured in 5 control mice was 2.54 ± 0.10 pmol/min/?
Gene_expression (activity) of peptidase
19) Confidence 0.15 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.27 Pain Relevance 0.05
The mean ± SEM peptidase activity measured with DAGNPG in 4 control patients was 0.31 ± 0.04 pmol/min/?
Gene_expression (activity) of peptidase
20) Confidence 0.15 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.64 Pain Relevance 0

General Comments

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