INT17274

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Context Info
Confidence 0.58
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 3.98
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Got1) biosynthetic process (Got1) cellular amino acid metabolic process (Got1)
lysosome (Got1) cytoplasm (Got1)
Anatomy Link Frequency
plasma 3
blood 1
liver 1
Got1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 4 100.00 Very High Very High Very High
Paracetamol 60 99.52 Very High Very High Very High
alcohol 3 99.28 Very High Very High Very High
Potency 156 81.64 Quite High
agonist 30 75.52 Quite High
Bile 9 71.52 Quite High
Inflammation 23 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 22 99.58 Very High Very High Very High
Hepatitis 3 98.76 Very High Very High Very High
Hepatic Encephalopathy 46 98.74 Very High Very High Very High
Cirrhosis 70 97.96 Very High Very High Very High
Poisoning 3 97.30 Very High Very High Very High
Hepatotoxicity 127 96.94 Very High Very High Very High
Body Weight 25 95.56 Very High Very High Very High
Shock 1 91.12 High High
Weight Loss 19 89.20 High High
Toxicity 88 88.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hepatotoxicity of paracetamol in mice of 2, 3, 8-10, 24-26, 32-34, and 52-54 wk of age was determined by lethality data, histopathologic examination of the liver, and appearance of glutamate-pyruvate transaminase and glutamate-oxaloacetate transaminase activities in the plasma over an 8-h exposure period.
Gene_expression (appearance) of transaminase in plasma associated with glutamate, paracetamol and hepatotoxicity
1) Confidence 0.58 Published 1991 Journal Pediatr. Res. Section Abstract Doc Link 1896254 Disease Relevance 0.32 Pain Relevance 0.35
The hepatotoxicity of paracetamol in mice of 2, 3, 8-10, 24-26, 32-34, and 52-54 wk of age was determined by lethality data, histopathologic examination of the liver, and appearance of glutamate-pyruvate transaminase and glutamate-oxaloacetate transaminase activities in the plasma over an 8-h exposure period.
Gene_expression (appearance) of transaminase in plasma associated with glutamate, paracetamol and hepatotoxicity
2) Confidence 0.58 Published 1991 Journal Pediatr. Res. Section Abstract Doc Link 1896254 Disease Relevance 0.33 Pain Relevance 0.35
Following intraperitoneal administration of CP (50-300 mg/kg), dose-dependent depletion of hepatic glutathione, increased serum transaminase (SGPT) levels and hepatic necrosis were observed.
Gene_expression (levels) of serum transaminase associated with necrosis
3) Confidence 0.44 Published 1985 Journal Br J Exp Pathol Section Abstract Doc Link 3882119 Disease Relevance 0.65 Pain Relevance 0.07
Serum alanine and aspartate transaminase levels were determined 24 h after administration of AAP.
Gene_expression (levels) of transaminase
4) Confidence 0.28 Published 1995 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 7496865 Disease Relevance 0.09 Pain Relevance 0
The effects of NAC, cimetidine and the two in combination, administered 2 h post-paracetamol dose, on mortality, plasma glutamic oxaloacetic (GOT) and glutamic pyruvic (GPT) transaminase activities and hepatic reduced glutathione (GSH) levels were investigated in mice 24 h after treatment with a single oral dose of paracetamol (400 mg/kg).
Gene_expression (activities) of transaminase in plasma associated with paracetamol
5) Confidence 0.24 Published 1997 Journal Toxicology Section Abstract Doc Link 9231700 Disease Relevance 0.17 Pain Relevance 0.35
governs metabolism of amino acids by suppressing expression of genes involved in transamination (Aspartate amino transferase (Got1), Alanine amino transferase (Gpt), Alanine glyoxylate aminotransferase (Agtx2), and deamination (Glutaminase (Gls)), as well as numerous genes that are part of the urea cycle (Cps1, Otc, Ass1, and Asl) [160, 161, 245].
Gene_expression (expression) of Got1
6) Confidence 0.16 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0 Pain Relevance 0.14
Acetaminophen (APAP) intoxication from overdosing can result in severe hepatic damage, which is characterized by hemorrhagic centrilobular necrosis and by towering the levels of transaminase.
Gene_expression (levels) of transaminase associated with necrosis, paracetamol and poisoning
7) Confidence 0.10 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410252 Disease Relevance 0.53 Pain Relevance 0.48
As part of the routine monitoring of animals during the study, plasma bilirubin and transaminase levels for all the high-dose groups were examined at Day 8 of the study in order to assess liver function.
Gene_expression (levels) of transaminase in liver
8) Confidence 0.10 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1802611 Disease Relevance 0.18 Pain Relevance 0.13
Modulation of gut flora was also associated with a significant reduction in blood ammonia levels and a reversal of minimal HE in 50% of patients [123]; improved hepatic function and serum transaminase levels in patients with alcohol- and hepatitis C-related cirrhosis have also been reported [124].
Gene_expression (levels) of transaminase in blood associated with cirrhosis, hepatic encephalopathy, hepatitis and alcohol
9) Confidence 0.08 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3017957 Disease Relevance 0.77 Pain Relevance 0.05
In contrast, the transaminase levels in mice treated with MOE ASOs were within the normal range.
Gene_expression (levels) of transaminase
10) Confidence 0.07 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1802611 Disease Relevance 0.56 Pain Relevance 0
Furthermore, organ weights, transaminase increases and histopathological observations upon necropsy were consistent with the previous results, with >50-fold increases in AST and ALT at the 1.5 and 4.5 ?
Gene_expression (increases) of transaminase
11) Confidence 0.07 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1802611 Disease Relevance 0.38 Pain Relevance 0.07

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