INT172759

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Context Info
Confidence 0.03
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.64
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS, REN) extracellular region (INS, REN) small molecule metabolic process (INS)
intracellular (REN) carbohydrate metabolic process (INS) response to stress (REN)
Anatomy Link Frequency
AT-1 2
INS (Homo sapiens)
REN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 26 5.00 Very Low Very Low Very Low
metalloproteinase 14 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 5 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
bradykinin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 136 68.24 Quite High
Prediabetic State 36 67.84 Quite High
Insulin Resistance 50 67.68 Quite High
Metabolic Syndrome 49 67.52 Quite High
Hypertension 27 67.36 Quite High
Toxicity 23 65.12 Quite High
Coronary Artery Disease 4 58.76 Quite High
Stress 68 50.00 Quite Low
Atherosclerosis 29 50.00 Quite Low
Hyperinsulinism 7 49.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Currently, there is evidence that a local tissue renin angiotensin aldosterone system (RAAS) is operative within the intima and islet as angiotensin type one (AT-1) receptors have been identified as being present on smooth muscle cells, endothelial cells, and the beta cells within the intima and islet [20,21] Insulin is known to upregulate the AT-1 receptor [22] and there exists cross talk between the insulin and the Ang II signaling systems [23] In 1995, Copper et al. were able to demonstrate that amylin activates the RAAS with elevations in renin and aldosterone in humans [24] and, in 2001, Ikeda et al. were able to demonstrate that insulin, proinsulin and amylin infusions resulted in significant increases in renin release and that proinsulin and amylin enhanced this insulin-stimulated renin release in the perfused rat kidney [25].
proinsulin Positive_regulation (enhanced) of Localization (release) of renin in AT-1
1) Confidence 0.03 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 0.64 Pain Relevance 0

General Comments

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