INT17276

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Context Info
Confidence 0.42
First Reported 1991
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 26.85
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HIVEP1) intracellular (HIVEP1) DNA binding (HIVEP1)
cytoplasm (HIVEP1)
Anatomy Link Frequency
T cells 6
plasma 4
microglial cell 2
HIVEP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 99.28 Very High Very High Very High
Kappa opioid receptor 3 99.10 Very High Very High Very High
Dismenorea 10 98.80 Very High Very High Very High
Neuronal excitability 1 98.48 Very High Very High Very High
Morphine 5 98.24 Very High Very High Very High
anticonvulsant 1 97.96 Very High Very High Very High
Leflunomide 54 97.44 Very High Very High Very High
headache 30 97.40 Very High Very High Very High
methadone 21 97.20 Very High Very High Very High
nociceptor 1 96.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 1656 100.00 Very High Very High Very High
Infection 989 100.00 Very High Very High Very High
Repression 2 100.00 Very High Very High Very High
Apoptosis 509 99.96 Very High Very High Very High
Leukocytosis 140 99.56 Very High Very High Very High
Reprotox - General 2 39 99.44 Very High Very High Very High
Viremia 30 98.92 Very High Very High Very High
Reprotox - General 1 13 98.80 Very High Very High Very High
Disease 85 97.94 Very High Very High Very High
Headache 30 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoblot analysis demonstrated that expression of GAAPs did not interfere with Bax expression levels (Figure 5B, right panel).
Neg (not) Negative_regulation (interfere) of Gene_expression (expression) of GAAP
1) Confidence 0.42 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.92 Pain Relevance 0
Immunofluorescence using U2OS-h-GAAP cells confirmed that h-GAAP protein expression was reduced to background by 36 h after transfection with GAAP siRNAs 1 and 3, but not with siRNA2 or GFP-siRNA (Figure 4E).
Neg (not) Negative_regulation (reduced) of Gene_expression (expression) of GAAP protein
2) Confidence 0.41 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.37 Pain Relevance 0.05
Immunoblotting demonstrated that h-GAAP protein expression was undetectable 56 h after transfection with GAAP siRNAs 1 and 3, but not with siRNA2 and GFP-siRNA (Figure 4F).
Negative_regulation (undetectable) of Gene_expression (expression) of GAAP protein
3) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.56 Pain Relevance 0.04
Stable expression of both viral GAAP (v-GAAP) and human GAAP (h-GAAP), which is expressed in all human tissues tested, inhibited apoptosis induced by intrinsic and extrinsic apoptotic stimuli.
Negative_regulation (inhibited) of Gene_expression (expression) of v-GAAP associated with apoptosis
4) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Abstract Doc Link PMC1803007 Disease Relevance 1.22 Pain Relevance 0
Stable expression of both viral GAAP (v-GAAP) and human GAAP (h-GAAP), which is expressed in all human tissues tested, inhibited apoptosis induced by intrinsic and extrinsic apoptotic stimuli.
Negative_regulation (inhibited) of Gene_expression (expression) of GAAP associated with apoptosis
5) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Abstract Doc Link PMC1803007 Disease Relevance 1.22 Pain Relevance 0
Stable expression of both viral GAAP (v-GAAP) and human GAAP (h-GAAP), which is expressed in all human tissues tested, inhibited apoptosis induced by intrinsic and extrinsic apoptotic stimuli.
Negative_regulation (inhibited) of Gene_expression (expression) of h-GAAP associated with apoptosis
6) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Abstract Doc Link PMC1803007 Disease Relevance 1.22 Pain Relevance 0
Stable expression of both viral GAAP (v-GAAP) and human GAAP (h-GAAP), which is expressed in all human tissues tested, inhibited apoptosis induced by intrinsic and extrinsic apoptotic stimuli.
Negative_regulation (inhibited) of Gene_expression (expression) of GAAP associated with apoptosis
7) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Abstract Doc Link PMC1803007 Disease Relevance 1.22 Pain Relevance 0
Stimulation of HIV1 production was observed for all the concentrations of morphine used (0.05 to 0.5 mg/ml).
Negative_regulation (Stimulation) of Gene_expression (production) of HIV1 associated with acquired immune deficiency syndrome or hiv infection and morphine
8) Confidence 0.34 Published 1991 Journal Res. Virol. Section Abstract Doc Link 1896643 Disease Relevance 0.63 Pain Relevance 0.42
The kappa opioid receptor (KOR) agonist U50,488 recently has been shown to inhibit HIV-1 p24 antigen production in acutely infected microglial cell cultures.
Negative_regulation (inhibit) of Gene_expression (production) of HIV-1 p24 in microglial cell associated with acquired immune deficiency syndrome or hiv infection, agonist and kappa opioid receptor
9) Confidence 0.29 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10665828 Disease Relevance 0.87 Pain Relevance 0.25
Unfortunately, no clinical studies to date have demonstrated that these products can prevent HIV infection, [5] and spermicides with the surfactant nonoxynol-9 (N-9) have caused mucosal erosion and ulceration, which may increase the risk of HIV acquisition. [6], [7]
Negative_regulation (prevent) of Gene_expression (infection) of HIV associated with acquired immune deficiency syndrome or hiv infection and infection
10) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2190795 Disease Relevance 1.18 Pain Relevance 0
This poses a number of constraints on programmes addressing the prevention of HIV transmission through contaminated injecting equipment as well as the operation of methadone maintenance programmes.
Negative_regulation (prevention) of Gene_expression (transmission) of HIV associated with acquired immune deficiency syndrome or hiv infection and methadone
11) Confidence 0.21 Published 2008 Journal Confl Health Section Body Doc Link PMC2330023 Disease Relevance 0.36 Pain Relevance 0.10
Although there were no HIV seroconversions during our study, only 15 women received an HIV test ?
Negative_regulation (received) of Gene_expression (test) of HIV associated with acquired immune deficiency syndrome or hiv infection
12) Confidence 0.07 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913674 Disease Relevance 0.99 Pain Relevance 0
In 2005, the United States Department of Health and Human Services Centers for Disease Control (CDC) outlined recommendations for the provision of combination antiretroviral medications to prevent HIV infection after unanticipated sexual exposure [1].
Negative_regulation (prevent) of Gene_expression (infection) of HIV associated with acquired immune deficiency syndrome or hiv infection, disease and infection
13) Confidence 0.07 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913674 Disease Relevance 1.27 Pain Relevance 0
As shown in Figure 2, control T cells, either untransduced or transduced with a lentivirus expressing GFP alone, supported vigorous HIV-1 replication, with peak HIV-1 p24 antigen production exceeding 1000 ng/ml.
Negative_regulation (supported) of Gene_expression (production) of HIV-1 in T cells associated with acquired immune deficiency syndrome or hiv infection
14) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925957 Disease Relevance 0.77 Pain Relevance 0
We show for the first time that the expression of ZAS3 and its related genes, ZAS1 and ZAS2, is decreased in the ipsilateral versus contralateral L6 DRG seven days after SpNL (Figure 8).
Negative_regulation (decreased) of Gene_expression (expression) of ZAS1
15) Confidence 0.05 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0.73 Pain Relevance 0.85
The following NRTI inhibitors of HIV-1 RT were tested in our XMRV replication assays: ZDV, 3?
Negative_regulation (inhibitors) of Gene_expression (tested) of HIV-1 associated with acquired immune deficiency syndrome or hiv infection
16) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2848589 Disease Relevance 0.36 Pain Relevance 0
Inhibitors of viruses other than HIV-1
Negative_regulation (Inhibitors) of Gene_expression (other) of HIV-1 associated with acquired immune deficiency syndrome or hiv infection
17) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2848589 Disease Relevance 0.61 Pain Relevance 0
In addition to the disproportionate CSF HIV response, CSF WBC counts were also suppressed in these subjects.
Negative_regulation (suppressed) of Gene_expression (response) of HIV associated with acquired immune deficiency syndrome or hiv infection
18) Confidence 0.03 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 0.43 Pain Relevance 0
When can pleocytosis be attributed to the underlying HIV infection and thus not warrant further diagnostic evaluations?
Negative_regulation (underlying) of Gene_expression (infection) of HIV associated with acquired immune deficiency syndrome or hiv infection, leukocytosis and infection
19) Confidence 0.03 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 1.78 Pain Relevance 0.28
His CSF VL was high (19,700 cpm), his plasma HIV level was nearly tenfold lower (2,800 cpm), and the usual ?
Negative_regulation (his) of Gene_expression (level) of HIV in plasma associated with acquired immune deficiency syndrome or hiv infection
20) Confidence 0.03 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 0.32 Pain Relevance 0

General Comments

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