INT17277

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 21.79
Pain Relevance 6.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HIVEP1) intracellular (HIVEP1) DNA binding (HIVEP1)
cytoplasm (HIVEP1)
Anatomy Link Frequency
HeLa 6
macrophages 5
lymphocytes 2
spinal cord 2
cleavage 2
HIVEP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 25 100.00 Very High Very High Very High
Opioid 25 99.92 Very High Very High Very High
Inflammation 42 99.60 Very High Very High Very High
chemokine 55 98.92 Very High Very High Very High
cytokine 54 97.20 Very High Very High Very High
MU agonist 3 94.92 High High
fibrosis 2 94.76 High High
Spinal cord 2 92.72 High High
opioid receptor 10 92.52 High High
antagonist 4 91.80 High High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 1270 100.00 Very High Very High Very High
Infection 653 100.00 Very High Very High Very High
Malaria 55 99.96 Very High Very High Very High
Hepatitis C Virus Infection 378 99.84 Very High Very High Very High
INFLAMMATION 45 99.60 Very High Very High Very High
Toxicity 5 99.60 Very High Very High Very High
Death 117 99.40 Very High Very High Very High
Apoptosis 584 98.48 Very High Very High Very High
Dementia 51 98.48 Very High Very High Very High
Encephalopathy 1 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, overexpression of human and viral GAAPs provides partial protection against apoptosis triggered by the extrinsic pathway, and this inhibition takes place downstream of caspase-8 cleavage.


Positive_regulation (overexpression) of Gene_expression (overexpression) of GAAP in cleavage associated with apoptosis
1) Confidence 0.67 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.40 Pain Relevance 0
Overexpression of h-GAAP or v-GAAP rendered cells resistant to induction of apoptosis, while knock down of expression of the human gene by siRNA caused cells to die by apoptosis.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of v-GAAP associated with targeted disruption and apoptosis
2) Confidence 0.59 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 1.00 Pain Relevance 0.03
Stimulation of HIV1 production was observed for all the concentrations of morphine used (0.05 to 0.5 mg/ml).
Positive_regulation (Stimulation) of Gene_expression (production) of HIV1 associated with acquired immune deficiency syndrome or hiv infection and morphine
3) Confidence 0.55 Published 1991 Journal Res. Virol. Section Abstract Doc Link 1896643 Disease Relevance 0.63 Pain Relevance 0.42
Strikingly, transfection of HeLa cells with GAAP siRNAs 1 and 3, but not GAAP siRNA2, induced cell death by 56 h post transfection (Figure 4B).
Positive_regulation (transfection) of Gene_expression (transfection) of GAAP siRNAs 1 in HeLa associated with death
4) Confidence 0.48 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.17 Pain Relevance 0.03
Strikingly, transfection of HeLa cells with GAAP siRNAs 1 and 3, but not GAAP siRNA2, induced cell death by 56 h post transfection (Figure 4B).
Positive_regulation (transfection) of Gene_expression (transfection) of GAAP siRNA2 in HeLa associated with death
5) Confidence 0.48 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.17 Pain Relevance 0.03
GAAP was transfected into CV-1 cells that were infected with VACV Evans, and a deletion mutant (v-?
Positive_regulation (transfected) of Gene_expression (transfected) of GAAP
6) Confidence 0.48 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0 Pain Relevance 0
Overexpression of h-GAAP or v-GAAP rendered cells resistant to induction of apoptosis, while knock down of expression of the human gene by siRNA caused cells to die by apoptosis.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of h-GAAP associated with targeted disruption and apoptosis
7) Confidence 0.42 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 1.00 Pain Relevance 0.03
Primers were h-GAAP forward: 5?
Positive_regulation (were) of Gene_expression (were) of h-GAAP
8) Confidence 0.42 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.08 Pain Relevance 0
Consistent with the cell morphology and the result of HeLa cell transfection (Figure 4B), U2OS-h-GAAP cells transfected with GAAP siRNAs 1 and 3 and U2OS-v-GAAP transfected with GAAP siRNA1 showed reduced uptake of TMRE (unpublished data).
Positive_regulation (transfected) of Gene_expression (transfected) of U2OS-v-GAAP in HeLa
9) Confidence 0.39 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.24 Pain Relevance 0
Our results indicate that treatment of U373 cells with morphine significantly downregulated the gene expression of the beta chemokine, MIP-1 beta, while reciprocally upregulating the expression of its specific receptors, CCR3 and CCR5 suggesting that the capacity of mu-opioids to increase HIV-1 co-receptor expression may promote viral binding, trafficking of HIV-1-infected cells, and enhanced disease progression.
Positive_regulation (increase) of Gene_expression (expression) of HIV-1 co-receptor associated with chemokine, acquired immune deficiency syndrome or hiv infection, opioid, disease progression and morphine
10) Confidence 0.15 Published 2005 Journal Curr. HIV Res. Section Abstract Doc Link 16022659 Disease Relevance 1.37 Pain Relevance 0.96
Our results support the hypothesis that opioids play a significant role in the susceptibility of the CNS to HIV-1 infection and subsequent encephalopathy by inhibiting local production of HIV-1-protective chemokines (IL-8 and macrophage-inflammatory protein-1beta) and enhancing expression of HIV-1 entry coreceptor genes (CCR3, CCR5, and CXCR2) within the CNS.
Positive_regulation (enhancing) of Gene_expression (expression) of HIV-1 in macrophage associated with chemokine, inflammation, encephalopathy, acquired immune deficiency syndrome or hiv infection, opioid and infection
11) Confidence 0.13 Published 2002 Journal J. Immunol. Section Abstract Doc Link 12244149 Disease Relevance 0.83 Pain Relevance 1.29
HIV-1 infection and Vpr protein potentiate the neuroimmune activation and neurotoxic effects of HCV core protein
Positive_regulation (potentiate) of Gene_expression (infection) of HIV associated with acquired immune deficiency syndrome or hiv infection, hepatitis c virus infection and infection
12) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.91 Pain Relevance 0.12
HIV-1 infection and Vpr protein potentiate the neuroimmune activation and neurotoxic effects of HCV core protein
Positive_regulation (potentiate) of Gene_expression (effects) of HIV associated with acquired immune deficiency syndrome or hiv infection, hepatitis c virus infection and infection
13) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.96 Pain Relevance 0.13
Survival of maC46-expressing primary human lymphocytes following HIV-1 infection
Positive_regulation (following) of Gene_expression (infection) of HIV-1 in lymphocytes associated with acquired immune deficiency syndrome or hiv infection and infection
14) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925957 Disease Relevance 0.77 Pain Relevance 0
However, in practice a number of factors may limit the ability of genetically-modified cells to expand and restore immune function in vivo, including the ongoing production of unmodified CD4+ T cells susceptible to HIV-1 infection, limitations in the proliferative capacity of modified cells, indirect mechanisms of cell death, and processes such as lymph node fibrosis that may affect the efficiency of CD4+ T cell reconstitution [29].
Positive_regulation (susceptible) of Gene_expression (infection) of HIV-1 in T cell associated with fibrosis, acquired immune deficiency syndrome or hiv infection, death and infection
15) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925957 Disease Relevance 1.00 Pain Relevance 0.11
and leads to an increase in HIV-1 gene expression [179] (Fig. 4).
Positive_regulation (increase) of Gene_expression (expression) of HIV associated with acquired immune deficiency syndrome or hiv infection
16) Confidence 0.04 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.67 Pain Relevance 0.07
Might reduced activation and lower CSF HIV levels relate to reduced fitness of the resistant viruses [52] or simply to a quantitative decrement in systemic infection?
Positive_regulation (activation) of Gene_expression (levels) of HIV associated with acquired immune deficiency syndrome or hiv infection and infection
17) Confidence 0.04 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 0.95 Pain Relevance 0.08
MGMT-mediated increase in marking of a lentiviral anti-HIV vector
Positive_regulation (increase) of Gene_expression (vector) of HIV associated with acquired immune deficiency syndrome or hiv infection
18) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765621 Disease Relevance 0.41 Pain Relevance 0
Construction of a mutant lentiviral rev helper plasmid for efficient production of anti-HIV vectors containing rev-specific shRNAs
Positive_regulation (Construction) of Gene_expression (vectors) of HIV associated with acquired immune deficiency syndrome or hiv infection
19) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765621 Disease Relevance 0.49 Pain Relevance 0
, IL-1, and IL-6, which are upregulated during malaria, increase HIV proviral expression through the provirus modulatory enhancer region (reviewed in [41]).
Positive_regulation (increase) of Gene_expression (expression) of HIV associated with malaria and acquired immune deficiency syndrome or hiv infection
20) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2744481 Disease Relevance 2.10 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox