INT172788

Context Info Confidence 0.01 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 3.54 Pain Relevance 0.28

cell differentiation (Vegfb) extracellular space (Vegfb) extracellular region (Vegfb) intracellular (Vegfb)

Anatomy Link Frequency smooth muscle 3 endothelial cells 1 Vegfb (Mus musculus)

Pain Link Frequency Relevance Heat cva 6 80.92 cytokine 4 66.16 Inflammatory mediators 4 65.40 Inflammation 52 64.08 metalloproteinase 28 5.00 Tetrahydrobiopterin 10 5.00 tolerance 10 5.00 Pain 6 5.00 ischemia 4 5.00 bradykinin 4 5.00

Disease Link Frequency Relevance Heat Hypoxia 4 98.14 Diabetes Mellitus 272 94.96 Atherosclerosis 58 94.24 Diabetic Retinopathy 2 88.56 Rupture 4 84.48 Hemorrhage 2 80.92 Prediabetic State 72 75.00 Insulin Resistance 100 74.84 Metabolic Syndrome 98 74.68 Stress 136 69.56

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Event

Anatomy

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The pseudohypoxia (increased ratio of NADH/NAD+ discussed by Williamson and Kilo see section (G) glucotoxicity.) in the polyol-sorbitol pathway as well as the true hypoxia induced by the increasing intima media thickness may act to induce the nuclear hypoxia inducible factor (hif-1) within the smooth muscle and endothelial cells which result in the increased expression of vascular endothelial growth factor VEGF which is so central and vital to the angiogenic process.

Positive_regulation (increased) of Gene_expression (expression) of factor VEGF in smooth muscle associated with hypoxia

1) Confidence 0.01 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.77 Pain Relevance 0.14

The pseudohypoxia (increased ratio of NADH/NAD+ discussed by Williamson and Kilo see section (G) glucotoxicity.) in the polyol-sorbitol pathway as well as the true hypoxia induced by the increasing intima media thickness may act to induce the nuclear hypoxia inducible factor (hif-1) within the smooth muscle and endothelial cells which result in the increased expression of vascular endothelial growth factor VEGF which is so central and vital to the angiogenic process.

Positive_regulation (increased) of in endothelial cells Gene_expression (expression) of factor VEGF in smooth muscle associated with hypoxia

2) Confidence 0.00 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.77 Pain Relevance 0.14

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