INT172788

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Context Info
Confidence 0.01
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.54
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Vegfb) extracellular space (Vegfb) extracellular region (Vegfb)
intracellular (Vegfb)
Anatomy Link Frequency
smooth muscle 3
endothelial cells 1
Vegfb (Mus musculus)
Pain Link Frequency Relevance Heat
cva 6 80.92 Quite High
cytokine 4 66.16 Quite High
Inflammatory mediators 4 65.40 Quite High
Inflammation 52 64.08 Quite High
metalloproteinase 28 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 10 5.00 Very Low Very Low Very Low
tolerance 10 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
bradykinin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 4 98.14 Very High Very High Very High
Diabetes Mellitus 272 94.96 High High
Atherosclerosis 58 94.24 High High
Diabetic Retinopathy 2 88.56 High High
Rupture 4 84.48 Quite High
Hemorrhage 2 80.92 Quite High
Prediabetic State 72 75.00 Quite High
Insulin Resistance 100 74.84 Quite High
Metabolic Syndrome 98 74.68 Quite High
Stress 136 69.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pseudohypoxia (increased ratio of NADH/NAD+ discussed by Williamson and Kilo see section (G) glucotoxicity.) in the polyol-sorbitol pathway as well as the true hypoxia induced by the increasing intima media thickness may act to induce the nuclear hypoxia inducible factor (hif-1) within the smooth muscle and endothelial cells which result in the increased expression of vascular endothelial growth factor VEGF which is so central and vital to the angiogenic process.
Positive_regulation (increased) of Gene_expression (expression) of factor VEGF in smooth muscle associated with hypoxia
1) Confidence 0.01 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.77 Pain Relevance 0.14
The pseudohypoxia (increased ratio of NADH/NAD+ discussed by Williamson and Kilo see section (G) glucotoxicity.) in the polyol-sorbitol pathway as well as the true hypoxia induced by the increasing intima media thickness may act to induce the nuclear hypoxia inducible factor (hif-1) within the smooth muscle and endothelial cells which result in the increased expression of vascular endothelial growth factor VEGF which is so central and vital to the angiogenic process.
Positive_regulation (increased) of in endothelial cells Gene_expression (expression) of factor VEGF in smooth muscle associated with hypoxia
2) Confidence 0.00 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.77 Pain Relevance 0.14

General Comments

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