INT172789

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Context Info
Confidence 0.53
First Reported 2002
Last Reported 2010
Negated 6
Speculated 3
Reported most in Body
Documents 15
Total Number 21
Disease Relevance 16.23
Pain Relevance 7.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) Golgi apparatus (Nos3) cytoplasm (Nos3)
signal transduction (Nos3) oxidoreductase activity (Nos3) nucleolus (Nos3)
Anatomy Link Frequency
sciatic nerve 6
endothelial cell 6
spinal cord 4
spinal nerve 2
sympathetic 2
Nos3 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 341 100.00 Very High Very High Very High
acular 50 100.00 Very High Very High Very High
dorsal root ganglion 45 99.68 Very High Very High Very High
Neuropathic pain 152 99.52 Very High Very High Very High
cytokine 23 99.46 Very High Very High Very High
Sciatic nerve 465 99.40 Very High Very High Very High
Inflammation 173 98.24 Very High Very High Very High
IPN 17 98.20 Very High Very High Very High
Eae 21 97.32 Very High Very High Very High
Analgesic 38 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 265 99.98 Very High Very High Very High
Ganglion Cysts 47 99.68 Very High Very High Very High
Targeted Disruption 649 99.64 Very High Very High Very High
Hypertension 161 99.60 Very High Very High Very High
Neuropathic Pain 364 99.52 Very High Very High Very High
Sciatic Neuropathy 6 99.40 Very High Very High Very High
INFLAMMATION 192 98.24 Very High Very High Very High
Inflammatory Pain 33 98.20 Very High Very High Very High
Increased Venous Pressure Under Development 70 97.84 Very High Very High Very High
Obesity 176 97.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results did not show significant changes in the expression of NOS2 and NOS3, mRNA and protein, on day 21th after sciatic nerve injury.
Neg (not) Regulation (changes) of Gene_expression (expression) of NOS3 in sciatic nerve associated with nervous system injury and sciatic nerve
1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 0.86 Pain Relevance 0.78
These results indicated that the compensatory changes in the spinal cord expression of NOS3 in NOS1-KO under basal conditions does not fully compensate for NOS1 function in neuropathic pain, which is mainly produced by NOS2.
Regulation (changes) of Gene_expression (expression) of NOS3 in spinal cord associated with targeted disruption, neuropathic pain and spinal cord
2) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.05 Pain Relevance 0.85
In support of this concept, estrogens have been shown to attenuate the severity of PH in rats [22], although the mechanism by which this occurs does not appear to be associated with alterations in eNOS expression [22].
Regulation (alterations) of Gene_expression (expression) of eNOS associated with hypertension
3) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982841 Disease Relevance 0.46 Pain Relevance 0
Another interesting finding in the present study is the correlation between nNOS and eNOS expression in the placebo, but not in the ketorolac treatment group, which suggests an inhibitory effect of ketorolac on eNOS gene expression.
Regulation (effect) of Gene_expression (expression) of eNOS gene associated with acular
4) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949722 Disease Relevance 0.46 Pain Relevance 0.64
Another interesting finding in the present study is the correlation between nNOS and eNOS expression in the placebo, but not in the ketorolac treatment group, which suggests an inhibitory effect of ketorolac on eNOS gene expression.
Regulation (correlation) of Gene_expression (expression) of eNOS associated with acular
5) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949722 Disease Relevance 0.47 Pain Relevance 0.58
The possible alterations in NOS2 and NOS3 expression induced by neuropathic pain have been also evaluated in this study.
Spec (possible) Regulation (alterations) of Gene_expression (expression) of NOS3 associated with neuropathic pain
6) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 0.86 Pain Relevance 0.76
Of note, the abolition of NOx release may also reflect the fact that the exasperated inflammation due to the lack of iNOS may trigger the release of cytokines (including TNFalpha) down-regulating the expression of eNOS [40].
Regulation (regulating) of Gene_expression (expression) of eNOS associated with inflammation and cytokine
7) Confidence 0.37 Published 2010 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2796899 Disease Relevance 0.61 Pain Relevance 0.18
The direct effects of estrogen on the vascular system which modulate_the vascular tonus comprise I) acute vasodilatation, increasing the synthesis and bioactivity of nitric oxide [7], II) long-term modulation of vascular tonus, regulating the production of prostaglandins and expression of eNOS and the endothelin gene [8], III) inhibition of endothelin-induced vasoconstriction [9], and IV) inhibition of sympathetic activity [8].
Regulation (regulating) of Gene_expression (expression) of eNOS in sympathetic associated with increased venous pressure under development
8) Confidence 0.30 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2923338 Disease Relevance 0.95 Pain Relevance 0.07
Our results revealed that
                   either obesity or age independently dampened the phosphorylation of Akt and its
                   downstream signaling molecule eNOS without affecting expression of Akt and eNOS.
                   
Neg (without) Regulation (affecting) of Gene_expression (expression) of eNOS associated with obesity
9) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.92 Pain Relevance 0
On the contrary, there was no difference in NOS-3 or NOS-1 mRNA levels between infected and control mice (data not shown).
Neg (no) Regulation (difference) of Gene_expression (levels) of NOS-3
10) Confidence 0.28 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2295255 Disease Relevance 0.06 Pain Relevance 0.03
Finally, we examined whether peripheral spinal nerve injury altered the expression of nNOS, iNOS, or eNOS in the DRG and spinal cord of WT mice.
Spec (whether) Regulation (altered) of Gene_expression (expression) of eNOS in spinal nerve associated with dorsal root ganglion, nervous system injury and spinal cord
11) Confidence 0.27 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.26 Pain Relevance 0.57
Estrogen has been shown to influence the expression and activity of endothelial nitric oxide synthase (eNOS) which is associated with increased S-nitrosothiol production.
Regulation (influence) of Gene_expression (expression) of eNOS
12) Confidence 0.25 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2982841 Disease Relevance 0.33 Pain Relevance 0
This uncoupling of eNOS plays an important role in endothelial cell dysfunction and increased oxidative stress. [47] Hyperglycemia and peroxynitrite (ONOO') also induce eNOS uncoupling with increases in O2' production. [48] Just published, Verma S and colleagues reported that CRP caused a marked down regulation of eNOS mRNA and protein expression with subsequent lower eNO production.
Regulation (regulation) of Gene_expression (expression) of eNOS in endothelial cell associated with hyperglycemia and stress
13) Confidence 0.24 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 0.90 Pain Relevance 0.10
However, the possible changes in the expression of NOS1, NOS2 and NOS3 isoforms that might occurs in the spinal cord of NOS1 and NOS2 knockout mice after total sciatic nerve ligation remains unknown.
Spec (possible) Regulation (changes) of Gene_expression (expression) of NOS3 in sciatic nerve associated with targeted disruption, sciatic nerve and spinal cord
14) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.02 Pain Relevance 0.94
In contrast to NOS1 and NOS2, the non significant changes in the spinal cord expression of NOS3 in the early (7 and 14 days) or late (21 days) phases of nerve injury suggest that this isoenzyme did not play an essential role in the development or maintenance of neuropathic pain [5], [11].
Regulation (changes) of Gene_expression (expression) of NOS3 in spinal cord associated with nervous system injury, neuropathic pain and spinal cord
15) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.06 Pain Relevance 0.70
In the present study, we also demonstrated that no compensatory changes in the spinal cord expression of NOS3 take place in sciatic nerve-injured NOS1 and NOS2 knockout mice as well as in sham-operated NOS2-KO mice [12].
Neg (no) Regulation (changes) of Gene_expression (expression) of NOS3 in sciatic nerve associated with targeted disruption, sciatic nerve and spinal cord
16) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.36 Pain Relevance 0.91
Reduced expression of eNOS could be responsible for decreased NO production, but in most situations where endothelial dysfunction is encountered, the expression of eNOS is increased paradoxically, most likely because oxidative stress generates hydrogen peroxide, which increases the expression of the enzyme.
Regulation (responsible) of Gene_expression (expression) of eNOS associated with stress
17) Confidence 0.23 Published 2010 Journal Curr Hypertens Rep Section Body Doc Link PMC2910890 Disease Relevance 0.66 Pain Relevance 0.09
HDL have been shown to activate also the protein kinase network Raf-1, MEK1/2, and ERK1/2 (Nofer, Junker, et al 2001; Norata, Callegari, et al 2004) that is responsible for the cell cycle entry and for eNOS activation (Nofer, Junker, et al 2001; Mineo et al 2003).
Regulation (responsible) of Gene_expression (activation) of eNOS associated with disorder of lipid metabolism
18) Confidence 0.22 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.10 Pain Relevance 0.08
However, the effects of androgens on eNOS expression and activity are in contrast to published data.
Regulation (effects) of Gene_expression (expression) of eNOS
19) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982841 Disease Relevance 0.48 Pain Relevance 0.03
High dose ASA, but not NCX 4016, inhibited endothelial cell expression of VCAM-1 and thrombomodulin in the carotid arteries at 4 weeks after irradiation; eNOS and ICAM-1 levels were unchanged.
Neg (unchanged) Regulation (unchanged) of Gene_expression (levels) of eNOS in endothelial cell
20) Confidence 0.21 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2943480 Disease Relevance 0.50 Pain Relevance 0.26

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