INT172796

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Context Info
Confidence 0.16
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.40
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) Golgi apparatus (Nos3) cytoplasm (Nos3)
signal transduction (Nos3) oxidoreductase activity (Nos3) nucleolus (Nos3)
Anatomy Link Frequency
endothelial cell 2
Nos3 (Mus musculus)
Pain Link Frequency Relevance Heat
Tetrahydrobiopterin 10 82.28 Quite High
Bioavailability 2 74.00 Quite High
Inflammation 52 68.40 Quite High
metalloproteinase 28 5.00 Very Low Very Low Very Low
tolerance 10 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 136 99.36 Very High Very High Very High
Hyperglycemia 18 96.56 Very High Very High Very High
Diabetes Mellitus 272 91.12 High High
Atherosclerosis 58 89.92 High High
Disease 24 82.24 Quite High
Hyperhomocysteinemia 6 80.20 Quite High
INFLAMMATION 56 68.40 Quite High
Metabolic Syndrome 98 50.88 Quite High
Insulin Resistance 100 50.56 Quite High
Prediabetic State 72 50.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ROS stemming from the A-FLIGHT toxicities additionally play a role in the competitive inhibition of eNOS.
Regulation (role) of Negative_regulation (inhibition) of eNOS
1) Confidence 0.16 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 0.56 Pain Relevance 0.13
This uncoupling of eNOS plays an important role in endothelial cell dysfunction and increased oxidative stress. [47] Hyperglycemia and peroxynitrite (ONOO') also induce eNOS uncoupling with increases in O2' production. [48] Just published, Verma S and colleagues reported that CRP caused a marked down regulation of eNOS mRNA and protein expression with subsequent lower eNO production.
Regulation (regulation) of Negative_regulation (regulation) of eNOS in endothelial cell associated with hyperglycemia and stress
2) Confidence 0.11 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 0.84 Pain Relevance 0.10

General Comments

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