INT172797

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Context Info
Confidence 0.24
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.47
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp1a) extracellular region (Mmp1a) proteinaceous extracellular matrix (Mmp1a)
Anatomy Link Frequency
chondrocytes 1
cartilage 1
CCV 1
Mmp1a (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 179 100.00 Very High Very High Very High
rheumatoid arthritis 162 99.00 Very High Very High Very High
Inflammation 235 94.12 High High
Arthritis 88 84.08 Quite High
cINOD 16 76.40 Quite High
fibrosis 38 69.92 Quite High
cytokine 72 68.32 Quite High
COX-2 inhibitor 4 62.32 Quite High
antagonist 15 61.32 Quite High
Osteoarthritis 32 56.52 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 162 99.00 Very High Very High Very High
Premature Birth 40 98.40 Very High Very High Very High
Severe Combined Immunodeficiency 22 97.36 Very High Very High Very High
Disease 179 95.28 Very High Very High Very High
INFLAMMATION 243 94.12 High High
Shock 1 93.36 High High
Diabetes Mellitus 141 92.96 High High
Prediabetic State 36 88.80 High High
Insulin Resistance 50 88.64 High High
Metabolic Syndrome 49 88.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that inhibition of MMP-1 by ribozymes has a protective effect on cartilage erosion in the SCID mouse co-implantation model.14 Both MMP-1 and MMP-13 contribute to the process of cartilage destruction in RA and can therefore be targeted for treatment.
Negative_regulation (inhibition) of MMP-1 in cartilage associated with severe combined immunodeficiency and rheumatoid arthritis
1) Confidence 0.24 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 1.35 Pain Relevance 0.45
We therefore performed an assay to investigate the ability of Marimastat to inhibit gelatinase (MMP-2, MMP-9) and interstitial collagenase (MMP-1) activities.
Negative_regulation (inhibit) of MMP-1
2) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.32 Pain Relevance 0.10
Furthermore, those mice in which ECE-1 and, consequently, MMP-1 levels were reduced were largely prevented from developing preterm delivery (manuscript submitted).
Negative_regulation (reduced) of MMP-1 associated with premature birth
3) Confidence 0.10 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.76 Pain Relevance 0.16
resulted in a significant reduction in detectable MMP-1 and MMP-3 levels when compared to that elicited by the IL-1?
Negative_regulation (reduction) of MMP-1 associated with metalloproteinase
4) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.52 Pain Relevance 0.90
In addition, the level of tissue inhibitor of MMP-1 (TIMP-1), a natural protein inhibitor produced by chondrocytes, also remained stable (data not shown).
Negative_regulation (inhibitor) of MMP-1 in chondrocytes associated with metalloproteinase
5) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.32 Pain Relevance 0.24
Inhibition of MMP-1 synthesis by retroviral over-expression of ribozymes that target MMP-1 mRNA resulted in a significant reduction of the invasiveness of RASFs in the SCID mouse model for RA [15], without affecting the production of other MMPs.
Negative_regulation (Inhibition) of MMP-1 associated with severe combined immunodeficiency, metalloproteinase and rheumatoid arthritis
6) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.86 Pain Relevance 0.79
aggregation inhibiting properties [127,190] and inhibition of expression of MMP-1, -3, -9, -14 [91].
Negative_regulation (inhibition) of MMP-1
7) Confidence 0.04 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644496 Disease Relevance 0.96 Pain Relevance 0.10
As plasmin is impaired there is a reduction of the conversion of inactive or pro-MMP-1 to active MMP-1 with inhibition of ECM turnover with resultant impaired CCV formation.
Negative_regulation (reduction) of MMP-1 in CCV
8) Confidence 0.03 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.39 Pain Relevance 0

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