INT172798

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Context Info
Confidence 0.41
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 11
Disease Relevance 4.64
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Vegfb) extracellular space (Vegfb) extracellular region (Vegfb)
intracellular (Vegfb)
Anatomy Link Frequency
eyes 1
endothelial cells 1
smooth muscle 1
HeLa 1
proximal 1
Vegfb (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 9 94.96 High High
cva 6 80.52 Quite High
cytokine 8 65.76 Quite High
Inflammatory mediators 6 65.00 Quite High
Inflammation 78 63.68 Quite High
metalloproteinase 30 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 10 5.00 Very Low Very Low Very Low
tolerance 10 5.00 Very Low Very Low Very Low
alcohol 9 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinal Neovascularization 21 98.92 Very High Very High Very High
Hypoxia 18 97.94 Very High Very High Very High
Diabetes Mellitus 272 94.96 High High
Atherosclerosis 58 94.24 High High
Corneal Neovascularization 40 93.28 High High
Candida Infection 4 91.24 High High
Diabetic Retinopathy 37 88.56 High High
Rupture 4 84.08 Quite High
Hemorrhage 2 80.52 Quite High
Keratitis 56 78.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Real-time reverse transcriptase polymerase chain reaction (RT-PCR) determined levels of genes encoding VEGF-A, VEGF-B, VEGF-C, and VEGF-D and placental growth factor in infected, mock-inoculated, and normal corneas.
Spec (determined) Gene_expression (levels) of VEGF-B in corneas
1) Confidence 0.41 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2756518 Disease Relevance 0.63 Pain Relevance 0
Compared to normal eyes, mock-inoculated controls were not significantly different in VEGF-A, VEGF-B, VEGF-C, VEGF-D, or PlGF expression levels.


Gene_expression (expression) of VEGF-B in eyes
2) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2756518 Disease Relevance 0.12 Pain Relevance 0.03
To determine whether the inhibition of proximal splice site selection by blocking SRPK1/2, and hence increased anti-angiogenic VEGF165b production, we used a mouse model of retinal neovascularization where angiogenesis is driven by hypoxia, a process known to favor proximal splice site selection.
Gene_expression (production) of VEGF165b in proximal associated with hypoxia and retinal neovascularization
3) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.29 Pain Relevance 0
It binds recombinant VEGF165b, and can be used to demonstrate expression of VEGF165b, VEGF189b, and VEGF121b (collectively termed VEGFxxxb) but does not recognize VEGF165, conclusively demonstrating that this antibody is specific for VEGFxxxb (6).
Gene_expression (expression) of VEGF165b
4) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
Interestingly, SRPK2 overexpression did not affect VEGF165b production, although it did reduce total VEGF expression.


Gene_expression (production) of VEGF165b
5) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
This is consistent with the cytoplasmic location of ASF/SF2 being associated with VEGF165b expression.


Gene_expression (expression) of VEGF165b
6) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
Epithelial cells treated with insulin-like growth factor-1 (IGF-1) increased PSS and produced more VEGF165 and less VEGF165b.
Gene_expression (produced) of VEGF165b in Epithelial cells
7) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2820781 Disease Relevance 0.07 Pain Relevance 0.05
PMA treatment resulted in a significant increase in VEGF expression as determined by Western blot, but a decrease in VEGF165b expression (Fig. 2A).
Gene_expression (expression) of VEGF165b
8) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
Fig. 4G shows that HEK cells (with cytoplasmic ASF/SF2) express VEGF165b, whereas HeLa cells (nuclear ASF/SF2) only express VEGF165.
Gene_expression (express) of VEGF165b in HeLa
9) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
The pseudohypoxia (increased ratio of NADH/NAD+ discussed by Williamson and Kilo see section (G) glucotoxicity.) in the polyol-sorbitol pathway as well as the true hypoxia induced by the increasing intima media thickness may act to induce the nuclear hypoxia inducible factor (hif-1) within the smooth muscle and endothelial cells which result in the increased expression of vascular endothelial growth factor VEGF which is so central and vital to the angiogenic process.
Gene_expression (expression) of factor VEGF in smooth muscle associated with hypoxia
10) Confidence 0.01 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.77 Pain Relevance 0.14
The pseudohypoxia (increased ratio of NADH/NAD+ discussed by Williamson and Kilo see section (G) glucotoxicity.) in the polyol-sorbitol pathway as well as the true hypoxia induced by the increasing intima media thickness may act to induce the nuclear hypoxia inducible factor (hif-1) within the smooth muscle and endothelial cells which result in the increased expression of vascular endothelial growth factor VEGF which is so central and vital to the angiogenic process.
Gene_expression (expression) of factor VEGF in endothelial cells associated with hypoxia
11) Confidence 0.00 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.77 Pain Relevance 0.14

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