INT172801

Context Info Confidence 0.08 First Reported 2002 Last Reported 2003 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 7.95 Pain Relevance 0.44

extracellular space (Tnfsf4)

Tnfsf4 (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 5 98.78 Inflammation 126 98.52 tolerance 21 72.24 cytokine 84 47.24 metalloproteinase 44 5.00 chemokine 16 5.00 Tetrahydrobiopterin 15 5.00 Angina 12 5.00 cva 9 5.00 Pain 9 5.00

Disease Link Frequency Relevance Heat Atherosclerosis 143 100.00 Hyperglycemia 31 99.98 Diabetes Mellitus 512 99.90 Disease 64 99.78 Metabolic Syndrome 149 98.68 Insulin Resistance 154 98.52 INFLAMMATION 148 98.52 Prediabetic State 110 98.36 Stress 206 98.16 Coronary Artery Disease 46 92.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Atheroscleropathy: The term used to describe the unique accelerated atherosclerosis observed in and associated with MS, IR, PD, and overt T2DM.

Positive_regulation (accelerated) of atherosclerosis associated with diabetes mellitus, atherosclerosis, prediabetic state, metabolic syndrome and insulin resistance

1) Confidence 0.08 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 2.82 Pain Relevance 0.12

In summary, there are two common threads that weave these two diseases (T2DM and accelerated atherosclerosis) together, resulting in the complex mosaic fabric of atheroscleropathy: Redox stress and inflamation.

Positive_regulation (accelerated) of atherosclerosis associated with stress, atherosclerosis, diabetes mellitus and disease

2) Confidence 0.05 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.89 Pain Relevance 0.12

Furthermore, there are advanced fructosylation endproducts (AFEs), which actually have a greater affinity binding to proteins than glucose and follow a similar pattern in the production of the ROS. [30-33] An excellent in depth review of AGE can be found in an article by Aronson and Rayfield where they discuss how hyperglycemia promotes atherosclerosis [34].

Positive_regulation (promotes) of atherosclerosis associated with hyperglycemia and atherosclerosis

3) Confidence 0.05 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 0.82 Pain Relevance 0.07

Atherosclerosis and diabetes present a pleiotropic progression in which inflammation appears to be a common background, and patients with diabetes experience accelerated atherosclerosis, which has been termed atheroscleropathy [72,73].

Positive_regulation (accelerated) of atherosclerosis associated with inflammation, diabetes mellitus and atherosclerosis

4) Confidence 0.04 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 1.15 Pain Relevance 0.05

Moreover, sequelae of chronic hyperglycemia, such as oxidative stress and increased protein kinase C production, are widely invoked as pathogenic mechanisms for accelerated atherosclerosis [75].

Positive_regulation (accelerated) of atherosclerosis associated with stress, hyperglycemia, kinase c and atherosclerosis

5) Confidence 0.03 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 1.28 Pain Relevance 0.08

General Comments

This test has worked.