INT172801

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Context Info
Confidence 0.08
First Reported 2002
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 7.95
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfsf4)
Tnfsf4 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 5 98.78 Very High Very High Very High
Inflammation 126 98.52 Very High Very High Very High
tolerance 21 72.24 Quite High
cytokine 84 47.24 Quite Low
metalloproteinase 44 5.00 Very Low Very Low Very Low
chemokine 16 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 15 5.00 Very Low Very Low Very Low
Angina 12 5.00 Very Low Very Low Very Low
cva 9 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerosis 143 100.00 Very High Very High Very High
Hyperglycemia 31 99.98 Very High Very High Very High
Diabetes Mellitus 512 99.90 Very High Very High Very High
Disease 64 99.78 Very High Very High Very High
Metabolic Syndrome 149 98.68 Very High Very High Very High
Insulin Resistance 154 98.52 Very High Very High Very High
INFLAMMATION 148 98.52 Very High Very High Very High
Prediabetic State 110 98.36 Very High Very High Very High
Stress 206 98.16 Very High Very High Very High
Coronary Artery Disease 46 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Atheroscleropathy: The term used to describe the unique accelerated atherosclerosis observed in and associated with MS, IR, PD, and overt T2DM.
Positive_regulation (accelerated) of atherosclerosis associated with diabetes mellitus, atherosclerosis, prediabetic state, metabolic syndrome and insulin resistance
1) Confidence 0.08 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 2.82 Pain Relevance 0.12
In summary, there are two common threads that weave these two diseases (T2DM and accelerated atherosclerosis) together, resulting in the complex mosaic fabric of atheroscleropathy:


Redox stress and inflamation.

Positive_regulation (accelerated) of atherosclerosis associated with stress, atherosclerosis, diabetes mellitus and disease
2) Confidence 0.05 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.89 Pain Relevance 0.12
Furthermore, there are advanced fructosylation endproducts (AFEs), which actually have a greater affinity binding to proteins than glucose and follow a similar pattern in the production of the ROS. [30-33] An excellent in depth review of AGE can be found in an article by Aronson and Rayfield where they discuss how hyperglycemia promotes atherosclerosis [34].
Positive_regulation (promotes) of atherosclerosis associated with hyperglycemia and atherosclerosis
3) Confidence 0.05 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 0.82 Pain Relevance 0.07
Atherosclerosis and diabetes present a pleiotropic progression in which inflammation appears to be a common background, and patients with diabetes experience accelerated atherosclerosis, which has been termed atheroscleropathy [72,73].
Positive_regulation (accelerated) of atherosclerosis associated with inflammation, diabetes mellitus and atherosclerosis
4) Confidence 0.04 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 1.15 Pain Relevance 0.05
Moreover, sequelae of chronic hyperglycemia, such as oxidative stress and increased protein kinase C production, are widely invoked as pathogenic mechanisms for accelerated atherosclerosis [75].
Positive_regulation (accelerated) of atherosclerosis associated with stress, hyperglycemia, kinase c and atherosclerosis
5) Confidence 0.03 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 1.28 Pain Relevance 0.08

General Comments

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