INT172802

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Context Info
Confidence 0.01
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.21
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CCV 1
T2dm2 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 3 63.84 Quite High
agonist 34 58.72 Quite High
cytokine 5 49.08 Quite Low
Inflammatory mediators 2 48.32 Quite Low
Inflammation 35 47.00 Quite Low
tolerance 8 7.36 Low Low
metalloproteinase 14 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 5 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 279 100.00 Very High Very High Very High
Atherosclerosis 39 98.76 Very High Very High Very High
Diabetic Retinopathy 1 91.96 High High
Weight Loss 15 88.60 High High
Hypoglycemia 30 84.00 Quite High
Obesity 49 83.36 Quite High
Metabolic Syndrome 55 82.88 Quite High
Insulin Resistance 58 82.56 Quite High
Prediabetic State 36 82.24 Quite High
Hypoxia 2 79.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After the study by Fukuhara suggested a role of visfatin on glucose metabolism, others have investigated its relationship with T2DM, insulin secretion and sensitivity, and also with other adipokines such as adiponectin.
Localization (secretion) of T2DM associated with diabetes mellitus
1) Confidence 0.01 Published 2010 Journal Diabetol Metab Syndr Section Body Doc Link PMC2857825 Disease Relevance 0.75 Pain Relevance 0
Even though patients with diabetes (both T1DM and T2DM) have a much higher number of atherosclerotic diseased arteries, mean coronary collateral vessels (CCV) are significantly decreased. [63]
Localization (diabetes) of T2DM in CCV associated with atherosclerosis and diabetes mellitus
2) Confidence 0.01 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.69 Pain Relevance 0.03
Furthermore, higher doses, and combinations, of OHA are progressively required in the majority of patients.4 The reasons for this are diverse and include difficulty in compliance with lifestyle modifications (diet, exercise) and medications; but perhaps, most importantly, the failure of these OHAs to target several underlying pathophysiologic mechanisms of T2DM, particularly inappropriately high glucagon secretion, impaired first-phase insulin secretion, and progressive ?
Localization (secretion) of T2DM associated with diabetes mellitus
3) Confidence 0.01 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2731024 Disease Relevance 0.77 Pain Relevance 0.03

General Comments

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