INT172808

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Context Info
Confidence 0.40
First Reported 2002
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 35
Total Number 37
Disease Relevance 31.39
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1) cell proliferation (ROS1) plasma membrane (ROS1)
Anatomy Link Frequency
brain 5
SH-SY5Y 2
macrophages 2
embryos 2
hepatocytes 2
ROS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 292 99.98 Very High Very High Very High
diclofenac 80 99.98 Very High Very High Very High
antagonist 51 98.70 Very High Very High Very High
Pain 13 96.96 Very High Very High Very High
Inflammation 346 94.92 High High
alcohol 25 87.36 High High
cytokine 178 84.80 Quite High
fibrosis 59 82.92 Quite High
Arthritis 10 81.76 Quite High
endometriosis 84 81.68 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 1984 100.00 Very High Very High Very High
Death 622 100.00 Very High Very High Very High
Infection 500 100.00 Very High Very High Very High
Urological Neuroanatomy 8 100.00 Very High Very High Very High
Targeted Disruption 55 99.88 Very High Very High Very High
Lung Cancer 53 99.86 Very High Very High Very High
Cancer 381 99.84 Very High Very High Very High
Toxicity 106 99.80 Very High Very High Very High
Stress 887 99.56 Very High Very High Very High
Mycobacterial Infection 987 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We next investigated whether the ROS accumulation is required for the potentiated cytotoxicity induced by saikosaponins and cisplatin co-treatment.
Spec (whether) Positive_regulation (required) of Spec (whether) Positive_regulation (accumulation) of ROS
1) Confidence 0.40 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3006358 Disease Relevance 0.32 Pain Relevance 0
increase towards the late secretory phase and ROS triggers the release of prostaglandin F2 ?
Positive_regulation (triggers) of Positive_regulation (increase) of ROS
2) Confidence 0.37 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.50 Pain Relevance 0.13
Poor quality embryos may be associated with increased generation of ROS [173].
Positive_regulation (increased) of Positive_regulation (generation) of ROS in embryos
3) Confidence 0.37 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0 Pain Relevance 0.08
ROS accumulation contributes to the synergistic cytotoxicity induced by saikosaponins plus cisplatin
Positive_regulation (contributes) of Positive_regulation (accumulation) of ROS
4) Confidence 0.29 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3006358 Disease Relevance 0.31 Pain Relevance 0
Our finding in this study also showed that both SSa and SSd induced significant cellular ROS accumulation in cancer cells, which substantially contribute to synergistic cytotoxicity in saikosaponin and cisplatin cotreated cell.
Positive_regulation (induced) of Positive_regulation (accumulation) of ROS associated with cancer
5) Confidence 0.27 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3006358 Disease Relevance 0.71 Pain Relevance 0
Importantly, we found that the chemosensitization effect of saikosaponin is mainly mediated by the induction of cellular reactive oxygen species (ROS) accumulation in cancer cells.
Positive_regulation (induction) of Positive_regulation (accumulation) of ROS associated with cancer
6) Confidence 0.27 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3006358 Disease Relevance 0.67 Pain Relevance 0
Probably the best detailed example of ROS involvement in cell death is related to the activation of death receptors, the mitochondria-related generation of ROS and the subsequent sustained activation of JNK.
Positive_regulation (activation) of Positive_regulation (generation) of ROS associated with death
7) Confidence 0.27 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.99 Pain Relevance 0.03
ROS activation of TRPV1 on vascular membranes also increases local blood flow [15].
Positive_regulation (increases) of Positive_regulation (activation) of ROS in blood
8) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC2924298 Disease Relevance 0.68 Pain Relevance 0.56
Other researchers have provided similar evidence for the HCV non-structural protein 5A (NS5A), which has been shown to associate with the membranes of endoplasmic reticulum (ER) and increase generation of ROS and activation of NF-?
Positive_regulation (increase) of Positive_regulation (activation) of ROS in reticulum associated with hepatitis c virus infection
9) Confidence 0.25 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.91 Pain Relevance 0.10
However, experimental studies have proposed that HCV core protein may induce mitochondrial injury in hepatocytes, leading to increased generation of ROS [163,164].
Positive_regulation (increased) of Positive_regulation (generation) of ROS in hepatocytes associated with injury and hepatitis c virus infection
10) Confidence 0.25 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 2.08 Pain Relevance 0.13
Moreover, heparin that is routinely used for anticoagulation during hemodialysis is known to activate MPO leading to increased ROS production [71].
Positive_regulation (activate) of Positive_regulation (increased) of ROS associated with urological neuroanatomy
11) Confidence 0.25 Published 2011 Journal Cardiology Research and Practice Section Body Doc Link PMC3022166 Disease Relevance 0.84 Pain Relevance 0.07
While treatment of cancer cells with sulindac or TBHP individually leads to a modest increase in the level of ROS (Figure 5B and [27], [32]), there is a dramatic increase in the intracellular levels of ROS in cells pretreated with sulindac and then exposed to TBHP (Figure 5D).
Positive_regulation (leads) of Positive_regulation (increase) of ROS associated with cancer
12) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2686156 Disease Relevance 1.17 Pain Relevance 0.06
Sulindac pretreatment of lung cancer cells leads to elevated levels of ROS and loss of mitochondrial membrane potential
Positive_regulation (leads) of Positive_regulation (elevated) of ROS in lung associated with lung cancer
13) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2686156 Disease Relevance 0.92 Pain Relevance 0
suggesting that ROS-mediated transcriptional activation of DR5 is important for
Positive_regulation (suggesting) of Positive_regulation (activation) of ROS-mediated
14) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.24 Pain Relevance 0.03
Indeed, we found that cocaine induces endogenous ROS accumulation as early as 15 min after treatment of AF5 cells (Figure 6D).
Positive_regulation (induces) of Positive_regulation (accumulation) of ROS associated with cocaine
15) Confidence 0.15 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.10 Pain Relevance 0.28
nuoG induces phagosomal ROS accumulation
Positive_regulation (phagosomal) of Positive_regulation (accumulation) of ROS
16) Confidence 0.14 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858756 Disease Relevance 1.42 Pain Relevance 0
This data also revealed that the DiI fluorescence is quenched in the presence of ROS and thus the bacterial staining is lost during infection with Mtb?
Positive_regulation (quenched) of Positive_regulation (presence) of ROS associated with mycobacterial infection and infection
17) Confidence 0.14 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858756 Disease Relevance 1.08 Pain Relevance 0
However, our data suggests that ROS signaling may also play a role at later stages of infection as NOX2-derived ROS are necessary for induction of apoptosis several days post infection (Figure 3).
Positive_regulation (necessary) of Positive_regulation (derived) of ROS associated with apoptosis and infection
18) Confidence 0.14 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858756 Disease Relevance 1.06 Pain Relevance 0
Thus, the increase of intracellular ROS induced by infection of cells with the nuoG mutant is required for the increase in TNF-?
Positive_regulation (increase) of Positive_regulation (induced) of ROS associated with infection
19) Confidence 0.13 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858756 Disease Relevance 0.87 Pain Relevance 0.03
Thus, the increase of intracellular ROS induced by infection of cells with the nuoG mutant is required for the increase in TNF-?
Positive_regulation (induced) of Positive_regulation (increase) of ROS associated with infection
20) Confidence 0.13 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858756 Disease Relevance 0.87 Pain Relevance 0.03

General Comments

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