INT172809

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Context Info
Confidence 0.40
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 33
Total Number 37
Disease Relevance 21.63
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ISL1) cytoplasm (ISL1)
Anatomy Link Frequency
amacrine cells 5
retina 2
pancreas 2
pancreatic islet 1
liver 1
ISL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 72 95.98 Very High Very High Very High
Inflammation 89 95.40 Very High Very High Very High
tolerance 25 92.92 High High
Neurotransmitter 48 88.64 High High
Serotonin 3 88.56 High High
Dopamine 24 86.56 High High
Enkephalin 36 84.96 Quite High
Somatostatin 25 82.32 Quite High
Spinal cord 93 81.36 Quite High
cytokine 8 76.52 Quite High
Disease Link Frequency Relevance Heat
Adenocarcinoma 678 100.00 Very High Very High Very High
Islet Cell Adenoma 290 100.00 Very High Very High Very High
Ganglion Cysts 288 100.00 Very High Very High Very High
Lymphatic System Cancer 50 100.00 Very High Very High Very High
Alzheimer's Dementia 39 100.00 Very High Very High Very High
Sarcoma 20 100.00 Very High Very High Very High
Cancer 453 99.96 Very High Very High Very High
Toxicity 71 99.16 Very High Very High Very High
Insulinoma 20 99.12 Very High Very High Very High
Diabetes Mellitus 517 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All of them expressed transcription factors pax-6, pdx 1, and isl-1 (Figure 2).
Gene_expression (expressed) of isl-1
1) Confidence 0.40 Published 2010 Journal Stem Cells International Section Body Doc Link PMC3010655 Disease Relevance 0.21 Pain Relevance 0.03
These cells expressed transcription factors pdx-1, pax-6, and isl-1, all three are central controlling genes capable of reprogramming nonpancreatic cells to surrogate ?
Gene_expression (expressed) of isl-1
2) Confidence 0.40 Published 2010 Journal Stem Cells International Section Body Doc Link PMC3010655 Disease Relevance 0.25 Pain Relevance 0
Coinciding with the onset of high insulin expression levels in mouse islets, ngn3 expression is virtually extinguished [25], while expression of Pdx1, FoxA3, Isl1, and Nkx6.1 in islet ?
Gene_expression (expression) of Isl1 associated with hyperinsulinism
3) Confidence 0.36 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.33 Pain Relevance 0
Cell pellet was then diluted with equal amount of medium and after testing for sterility, viability, and cell counts, subjected to immunofluorescence test for expression of transcription factors, paired box 6 (Pax-6), marker for glucagon production, isl-1, key regulator for normal islet cell development, which is the gene upregulating expression of insulin, and pancreatic duodenal homeobox gene (pdx-1) which is the regulator of ?
Gene_expression (production) of isl-1 associated with infertility
4) Confidence 0.31 Published 2010 Journal Stem Cells International Section Body Doc Link PMC3010655 Disease Relevance 0.15 Pain Relevance 0
mL, expressing Pax-6, Isl-1, and pdx-1, cell counts: 2.1 × 103/?
Gene_expression (expressing) of Isl-1
5) Confidence 0.31 Published 2010 Journal Stem Cells International Section Abstract Doc Link PMC3010655 Disease Relevance 0.66 Pain Relevance 0
Similarly, we noted that IPC maturation from stage 3 to 4 was accompanied by increased insulin expression, reduced ngn3 expression, and increased or maintained levels of Isl1, FoxA3, and Pdx1 expression (see Figure 1B and 1C).
Gene_expression (expression) of Isl1 in stage 3 associated with hyperinsulinism
6) Confidence 0.31 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.37 Pain Relevance 0
0.44% of cells expressed the MNP marker Isl-1, 98.8+/?
Gene_expression (expressed) of Isl-1
7) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0.13 Pain Relevance 0.06
Human cells (Fig. 4a) within the ventral horns double stained with Isl-1 (Fig. 4b), p75 (Fig. 4c; p75 in red, human nuclei in green), neurofilament or ChAT (Fig. 4d; ChAT in blue, human nuclei in brown), consistent with a MN lineage of mixed maturation state.
Gene_expression (stained) of Isl-1 in horns
8) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0.60 Pain Relevance 0.08
These cells were intermingled with Islet1-expressing cells in the GCL, suggesting that the cholinergic cells begin to differentiate among a heterogeneous pool of post-mitotic Islet1+/ChAT- cells.
Gene_expression (expressing) of Islet1
9) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0.16 Pain Relevance 0
The cholinergic cells may be among the first types of amacrine cell to differentiate, with the onset of ChAT and Islet1 expression occurring while these cells are interspersed among the developing ganglion cells at E6.
Gene_expression (expression) of Islet1 in amacrine cell associated with ganglion cysts
10) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0.17 Pain Relevance 0.21
Unlike other types of amacrine cells, the cholinergic cells express Islet1 with the onset of differentiation and into the mature retina, consistent with reports in the embryonic rat retina [28].
Gene_expression (express) of Islet1 in retina
11) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0 Pain Relevance 0
Islet1 is a homeotic LIM-domain transcription factor that is known to be expressed by bipolar, horizontal, and ganglion cells in the retina [29].
Gene_expression (expressed) of Islet1 in retina associated with ganglion cysts
12) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0.19 Pain Relevance 0
However, we found that muscarinic compounds did not affect non-cholinergic cells expressing calretinin, Islet1 or Brn3a-positive ganglion cells, and we failed to observe an increase in immunolabeling for cleaved-caspase 3.
Gene_expression (expressing) of Islet1 in ganglion cells associated with ganglion cysts
13) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0.10 Pain Relevance 0
At E6, Islet1 was expressed by ChAT-immunoreactive cells prior to the formation of the presumptive IPL (Figs. 1c–e).
Gene_expression (expressed) of Islet1
14) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0.17 Pain Relevance 0
Genes specifying transcription factors essential for in vivo differentiation of lineage-restricted neural progenitors and their differentiated progeny [21,22,23], including En1, Hb9, Isl1, Hoxc6, NRSF/REST, and Nkx6.1, were expressed at low or undetectable levels in stage 1 (see Figure 1B–1C), consistent with the reported multipotency of proliferating NSs grown in high glucose [14].
Gene_expression (expressed) of Isl1 in stage 1
15) Confidence 0.12 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0 Pain Relevance 0
In the developing rodent retina, cholinergic amacrine cells are known to express Islet1 [28].
Gene_expression (express) of Islet1 in amacrine cells
16) Confidence 0.12 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0.17 Pain Relevance 0
Cholinergic amacrine cells express Islet1 and Pax6 as they differentiate
Gene_expression (express) of Islet1 in amacrine cells
17) Confidence 0.10 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0.15 Pain Relevance 0
We found that as ChAT-immunoreactive cells differentiate they expressed the homeodomain transcription factors Pax6 and Islet1, and the cell-cycle inhibitor p27kip1.
Gene_expression (expressed) of Islet1
18) Confidence 0.10 Published 2008 Journal BMC Dev Biol Section Abstract Doc Link PMC2267169 Disease Relevance 0.09 Pain Relevance 0
To test whether homeodomain transcription factors in addition to Islet1 are expressed by developing cholinergic amacrine cells, we double-labeled sections with antibodies to ChAT and Pax6, AP2?
Gene_expression (expressed) of Islet1 in amacrine cells
19) Confidence 0.10 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0.22 Pain Relevance 0
Accordingly, this microenvironment may promote the expression of genes common to both ganglion and type-II cells (including Pax6, Islet1 and neurofilament).
Gene_expression (expression) of Islet1 in ganglion associated with ganglion cysts
20) Confidence 0.10 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0.54 Pain Relevance 0.15

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