INT172816

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Context Info
Confidence 0.06
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.91
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) Golgi apparatus (Nos3) cytoplasm (Nos3)
signal transduction (Nos3) extracellular space (Crp) oxidoreductase activity (Nos3)
Anatomy Link Frequency
endothelial cell 2
Crp (Mus musculus)
Nos3 (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 1 76.24 Quite High
Inflammation 26 70.64 Quite High
Tetrahydrobiopterin 5 55.64 Quite High
metalloproteinase 14 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 9 97.06 Very High Very High Very High
Stress 68 96.66 Very High Very High Very High
Atherosclerosis 29 92.16 High High
Disease 12 84.48 Quite High
INFLAMMATION 28 70.64 Quite High
Diabetes Mellitus 136 64.48 Quite High
Hyperhomocysteinemia 3 53.56 Quite High
Metabolic Syndrome 49 53.12 Quite High
Insulin Resistance 50 52.80 Quite High
Prediabetic State 36 52.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This uncoupling of eNOS plays an important role in endothelial cell dysfunction and increased oxidative stress. [47] Hyperglycemia and peroxynitrite (ONOO') also induce eNOS uncoupling with increases in O2' production. [48] Just published, Verma S and colleagues reported that CRP caused a marked down regulation of eNOS mRNA and protein expression with subsequent lower eNO production.
CRP Positive_regulation (caused) of Transcription (expression) of eNOS in endothelial cell associated with hyperglycemia and stress
1) Confidence 0.06 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 0.91 Pain Relevance 0.10

General Comments

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