INT17283

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Context Info
Confidence 0.59
First Reported 1982
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 37
Total Number 37
Disease Relevance 24.16
Pain Relevance 10.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (CSF1) cell proliferation (CSF1) extracellular space (CSF1)
extracellular region (CSF1) plasma membrane (CSF1)
Anatomy Link Frequency
macrophage 10
plasma 4
monocyte 4
osteoclasts 3
CSF 2
CSF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 171 100.00 Very High Very High Very High
metalloproteinase 50 100.00 Very High Very High Very High
endometriosis 504 99.96 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 11 99.82 Very High Very High Very High
Migraine 12 99.68 Very High Very High Very High
spinal inflammation 4 99.68 Very High Very High Very High
Angina 5 99.28 Very High Very High Very High
Cluster headache 8 99.16 Very High Very High Very High
rheumatoid arthritis 47 97.16 Very High Very High Very High
withdrawal 4 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Endometriosis 672 99.96 Very High Very High Very High
Syndrome 13 99.90 Very High Very High Very High
Colorectal Cancer 95 99.84 Very High Very High Very High
Sepsis 35 99.84 Very High Very High Very High
Pancreatic Cancer 19 99.84 Very High Very High Very High
Headache 20 99.68 Very High Very High Very High
Low Back Pain 6 99.68 Very High Very High Very High
Sleep Disorders 16 99.56 Very High Very High Very High
Cardiovascular Disease 6 99.40 Very High Very High Very High
Myocardial Infarction 11 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CSF-HA was found to be increased after all premedications with great individual variation (range 0.07-7.4 pmol/ml).
Positive_regulation (increased) of CSF-HA
1) Confidence 0.59 Published 1991 Journal Agents Actions Section Abstract Doc Link 1897441 Disease Relevance 0 Pain Relevance 0.68
There were no increased plasma levels of interleukin-6 or macrophage colony-stimulating factor (M-CSF) during rhIL-3.
Neg (no) Positive_regulation (increased) of M-CSF in macrophage
2) Confidence 0.47 Published 1993 Journal Ann. Hematol. Section Abstract Doc Link 8218538 Disease Relevance 0.73 Pain Relevance 0.28
PTCA induced increases in plasma levels of M-CSF in the coronary circulation.
Positive_regulation (increases) of M-CSF in plasma associated with percutaneous transluminal coronary angioplasty
3) Confidence 0.47 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11369010 Disease Relevance 0.23 Pain Relevance 0.52
Clinical significance of increased plasma concentration of macrophage colony-stimulating factor in patients with angina pectoris.
Positive_regulation (increased) of macrophage colony-stimulating factor in plasma associated with angina
4) Confidence 0.45 Published 2000 Journal J. Am. Coll. Cardiol. Section Title Doc Link 10716468 Disease Relevance 0.38 Pain Relevance 0.10
An examination of the plasma from the HM patient revealed that monocyte colony stimulating factor (MCSF) levels were elevated (6.4 and 5.78 compared to a control range of 1-1.75 ng/ml).
Positive_regulation (elevated) of MCSF in monocyte
5) Confidence 0.44 Published 1997 Journal Am. J. Hematol. Section Abstract Doc Link 9395179 Disease Relevance 0.07 Pain Relevance 0.54
CONCLUSIONS: These findings suggest that an increased circulating MCSF concentration reflects atherosclerotic progression in patients with CAD and predicts future cardiac events.


Positive_regulation (increased) of MCSF
6) Confidence 0.39 Published 2000 Journal J. Am. Coll. Cardiol. Section Body Doc Link 10716468 Disease Relevance 0.05 Pain Relevance 0
There were no increased plasma levels of interleukin-6 or macrophage colony-stimulating factor (M-CSF) during rhIL-3.
Neg (no) Positive_regulation (increased) of macrophage colony-stimulating factor in macrophage
7) Confidence 0.36 Published 1993 Journal Ann. Hematol. Section Abstract Doc Link 8218538 Disease Relevance 0.73 Pain Relevance 0.28
Receptor activator of nuclear factor kappa-B ligand (RANKL), macrophage colony-stimulating factor (M-CSF), and TNF?
Positive_regulation (activator) of macrophage colony-stimulating factor in macrophage
8) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: These findings suggest that among the studied inflammatory indices only increased admission levels of MCSF are strongly and independently related with adverse short-term prognosis in patients with severe unstable angina.


Positive_regulation (increased) of MCSF
9) Confidence 0.30 Published 2002 Journal Clin Cardiol Section Body Doc Link 12430780 Disease Relevance 0 Pain Relevance 0
In addition, serum levels of M-CSF are more associated with lymph node metastasis than CEA and CA 19-9, which suggests that serum M-CSF elevation in CRC patients might help predict the risk of lymph node metastasis of this tumor.
Positive_regulation (elevation) of M-CSF in lymph node associated with colorectal cancer, cancer and metastasis
10) Confidence 0.30 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.44 Pain Relevance 0
OBJECTIVE: To assess the usefulness of measuring serum matrix metalloproteinase 3 (MMP-3) and macrophage colony-stimulating factor (M-CSF) in patients with ankylosing spondylitis (AS).
Positive_regulation (measuring) of macrophage colony-stimulating factor in macrophage associated with spinal inflammation and metalloproteinase
11) Confidence 0.25 Published 2004 Journal Arthritis Rheum. Section Abstract Doc Link 15478146 Disease Relevance 0.25 Pain Relevance 0.26
There were significant differences in the levels of circulating SCF, M-CSF, CEA and CA 19-9 in the pancreatic cancer patients compared to the control group, but only the serum levels of M-CSF, CEA and CA 19-9 were significantly higher in pancreatic cancer patients compared to the pancreatitis group.
Positive_regulation (circulating) of M-CSF associated with pancreatitis and pancreatic cancer
12) Confidence 0.24 Published 2004 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 15080556 Disease Relevance 1.22 Pain Relevance 0.37
There were significant differences in the levels of circulating SCF, M-CSF, CEA and CA 19-9 in the pancreatic cancer patients compared to the control group, but only the serum levels of M-CSF, CEA and CA 19-9 were significantly higher in pancreatic cancer patients compared to the pancreatitis group.
Positive_regulation (higher) of M-CSF associated with pancreatitis and pancreatic cancer
13) Confidence 0.24 Published 2004 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 15080556 Disease Relevance 1.23 Pain Relevance 0.35
macrophages, as previously stated for macrophage colony-stimulating factor [36].
Positive_regulation (stated) of macrophage colony-stimulating factor in macrophage
14) Confidence 0.23 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.31 Pain Relevance 0
OBJECTIVE: To assess the usefulness of measuring serum matrix metalloproteinase 3 (MMP-3) and macrophage colony-stimulating factor (M-CSF) in patients with ankylosing spondylitis (AS).
Positive_regulation (measuring) of M-CSF in macrophage associated with spinal inflammation and metalloproteinase
15) Confidence 0.22 Published 2004 Journal Arthritis Rheum. Section Abstract Doc Link 15478146 Disease Relevance 0.25 Pain Relevance 0.26
Estradiol appears to decrease the responsiveness of osteoclasts to factors such as receptor activator of nuclear factor kappa B ligand (RANKL) and macrophage-colony stimulating factor (M-CSF), released in the bone microenvironment by osteogenic cells and by marrow stroma (Hughes et al 1996; Taranta et al 2002).
Positive_regulation (activator) of macrophage-colony stimulating factor in osteoclasts
16) Confidence 0.22 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684086 Disease Relevance 0.66 Pain Relevance 0.12
Activated progenitor cells can produce numerous cytokines such as IL-6, IL-11, macrophage colony stimulating factor (M-CSF), GM-CSF and SCF.41 These cytokines can further activate more limbal stem cells, neutrophils and macrophages.
Positive_regulation (activate) of macrophage colony stimulating factor in macrophages associated with cytokine
17) Confidence 0.19 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815811 Disease Relevance 0.43 Pain Relevance 0.19
Estradiol appears to decrease the responsiveness of osteoclasts to factors such as receptor activator of nuclear factor kappa B ligand (RANKL) and macrophage-colony stimulating factor (M-CSF), released in the bone microenvironment by osteogenic cells and by marrow stroma (Hughes et al 1996; Taranta et al 2002).
Positive_regulation (activator) of M-CSF in osteoclasts
18) Confidence 0.19 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684086 Disease Relevance 0.66 Pain Relevance 0.12
Activated progenitor cells can produce numerous cytokines such as IL-6, IL-11, macrophage colony stimulating factor (M-CSF), GM-CSF and SCF.41 These cytokines can further activate more limbal stem cells, neutrophils and macrophages.
Positive_regulation (activate) of M-CSF in macrophages associated with cytokine
19) Confidence 0.17 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815811 Disease Relevance 0.37 Pain Relevance 0.16
This pathological process consists of active phagocytosis of megakaryocytes and other hematopoietic cells by monocytes and macrophages, hypothetically in response to high levels of macrophage colony stimulating factor in sepsis [16].
Positive_regulation (levels) of macrophage colony stimulating factor in macrophages associated with sepsis
20) Confidence 0.12 Published 2006 Journal Crit Care Section Body Doc Link PMC1750988 Disease Relevance 1.92 Pain Relevance 0.09

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