INT172852

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 28
Total Number 30
Disease Relevance 21.42
Pain Relevance 3.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cyct) transport (Cyct) mitochondrion (Cyct)
Anatomy Link Frequency
neuronal 2
neurons 1
cleavage 1
brain 1
Cyct (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 353 98.24 Very High Very High Very High
Electroencephalography 169 97.04 Very High Very High Very High
Neurobehavioral 26 87.60 High High
Pyramidal cell 26 87.44 High High
gABA 65 80.72 Quite High
alcohol 29 80.48 Quite High
imagery 150 80.20 Quite High
Hippocampus 73 77.80 Quite High
cytokine 19 77.76 Quite High
Inflammation 68 76.12 Quite High
Disease Link Frequency Relevance Heat
Convulsion 819 99.72 Very High Very High Very High
Apoptosis 800 99.62 Very High Very High Very High
Death 541 99.60 Very High Very High Very High
Stress 102 99.20 Very High Very High Very High
Parkinson's Disease 24 99.16 Very High Very High Very High
INFLAMMATION 82 96.72 Very High Very High Very High
Drug Induced Neurotoxicity 92 91.04 High High
Pancreatic Cancer 84 90.72 High High
Neurodegenerative Disease 28 90.48 High High
Epilepsy 247 89.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This increased pro/anti-apoptotic protein ratio triggers cytochrome C release from mitochondria, which in turn activates caspase cascade and results in apoptosis.
Localization (release) of cytochrome C associated with apoptosis
1) Confidence 0.78 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.34 Pain Relevance 0.16
R-flurbiprofen and salicylate prevent also cytochrome c release induced by A?
Localization (release) of cytochrome c
2) Confidence 0.78 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.62 Pain Relevance 0.39
For quantification of cytochrome c release by confocal microscopy, the relative abundance (%) of cells showing diffuse vs. punctate immunofluorescence was calculated [60].


Localization (release) of cytochrome c
3) Confidence 0.78 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.38 Pain Relevance 0
As for possible mechanisms underlying its anti-apoptotic action, EGb761 may maintain the integrity of the mitochondrial membrane; prevent cytochrome c release from the mitochondria, thereby blocking the formation of the apoptosome and the apoptotic caspase cascade; enhance the transcription of antiapoptotic Bcl-2-like protein; attenuate the transcription of pro-apoptotic caspase-12; inactivate pro-apoptotic c-Jun N-terminal kinase (JNK), thereby “turning off” downstream target c-Jun; inhibit the cleavage of the key effector protease caspase-3, thereby blocking the execution of apoptosis and prevent nuclear DNA fragmentation, the molecular hallmark of apoptosis [3,7,50].
Localization (release) of cytochrome c in cleavage associated with apoptosis
4) Confidence 0.78 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820992 Disease Relevance 1.30 Pain Relevance 0
Bcl-xL is a member of the Bcl-2 family that acts on the mitochondrial membrane to prevent release of caspase activators such as cytochrome-C [27].
Localization (release) of cytochrome-C
5) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 1.20 Pain Relevance 0
In particular, mitochondrial Ca2+ overload can favor cardiolipin peroxidation, thereby affecting mitochondrial permeability transition, inducing AIF and cytochrome C release, and culminating in mitochondrial dysfunction and apoptosis [61], [62].
Localization (release) of cytochrome C associated with parkinson's disease and apoptosis
6) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.45 Pain Relevance 0
Bcl-2 family members regulate apoptosis by modulating the release of cytochrome c from mitochondria to cytosol.
Localization (release) of cytochrome c associated with apoptosis
7) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.95 Pain Relevance 0
Furthermore, inhibition of mitochondrial Ca2+ uptake by low concentrations of FCCP inhibit both cytochrome c release and cell death without preventing A?
Localization (release) of cytochrome c associated with death
8) Confidence 0.78 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.60 Pain Relevance 0
Therefore, the ability of lapatinib to reduce the levels of Bcl-xL and IAP-2 should increase mitochondria outer membrane permeabilization (MOMP), release cytochrome-C, and induce apoptosis.
Localization (release) of cytochrome-C associated with apoptosis
9) Confidence 0.73 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 1.38 Pain Relevance 0.03
These observations were further confirmed in primary hippocampal neuronal cells culture by the translocation of cytochrome-c and caspase-3 using confocal microscopy which revealed a diffuse staining pattern of cytochrome-c, suggesting its release from mitochondria (cytochrome-c, green FITC-labeled) along with caspase-3 (TRITC-labeled, red) upon treatments with PTZ, ethanol and PTZ plus ethanol.
Localization (translocation) of cytochrome-c in neuronal
10) Confidence 0.73 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.28 Pain Relevance 0.06
Visualization of mitochondrial cytochrome-c release and caspase-3 expression
Localization (release) of cytochrome-c
11) Confidence 0.73 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0 Pain Relevance 0
PTZ-induced seizure enhances the release of cytochrome-c
Localization (release) of cytochrome-c associated with convulsion
12) Confidence 0.73 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.93 Pain Relevance 0.09
Cytochrome-c is a mitochondrial inner membrane protein, which upon release into the cytosol elicits a cascade of events that ultimately activates caspases-3.
Localization (release) of Cytochrome-c
13) Confidence 0.73 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.93 Pain Relevance 0.09
Our findings indicate that primary culture from PTZ-induced seizure model triggers robust caspase-3 activation, release of cytochrome-c and decrease GABAB1R expression which has further decreasing effect on PKA expression level in hippocampal neurons of prenatal rat brain, while the co treatment of baclofen and phaclofen reverse the effects of PTZ and provide neuroprotection.
Localization (release) of cytochrome-c in brain associated with convulsion
14) Confidence 0.73 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.70 Pain Relevance 0.03
Mitochondrial cytochrome-c release is a key event in the activation of caspase-3, a downstream pivotal step to initiate apoptosis [8].
Localization (release) of cytochrome-c associated with apoptosis
15) Confidence 0.73 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 1.68 Pain Relevance 0.18
The in situ analysis of cytochrome-c release and caspase-3 expression was carried out by immunofluorescence technique.
Localization (release) of cytochrome-c
16) Confidence 0.73 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0 Pain Relevance 0
Figure 2(a) illustrated that exposure of cultured hippocampal neurons to ethanol, PTZ, ethanol plus PTZ and KA caused significant increased expression of cytochrome-c in PTZ-induced seizure as compare to non PTZ treated group, suggesting that release of cytochrome-c into the cytoplasm induces the formation of apoptosome.
Localization (release) of cytochrome-c in neurons associated with convulsion
17) Confidence 0.73 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.36 Pain Relevance 0.06
We find that FCCP at 100 nM prevents both cytochrome c release induced by both A?
Localization (release) of cytochrome c
18) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.42 Pain Relevance 0
oligomers-induced cytochrome c release and cell death.
Localization (release) of cytochrome c associated with death
19) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.61 Pain Relevance 0.69
1–42 oligomers-induced cytochrome c release and cell death.
Localization (release) of cytochrome c associated with death
20) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.41 Pain Relevance 0

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