INT172853

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 10.48
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cyct) transport (Cyct) mitochondrion (Cyct)
Anatomy Link Frequency
neurons 2
brain 2
Cyct (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 241 98.56 Very High Very High Very High
Electroencephalography 65 97.56 Very High Very High Very High
Neurobehavioral 10 90.24 High High
alcohol 11 83.12 Quite High
gABA 25 81.92 Quite High
Inflammation 42 76.44 Quite High
Hippocampus 32 74.80 Quite High
cytokine 8 63.52 Quite High
Central nervous system 20 62.88 Quite High
ischemia 3 49.80 Quite Low
Disease Link Frequency Relevance Heat
Convulsion 315 99.98 Very High Very High Very High
Apoptosis 353 99.70 Very High Very High Very High
Death 300 99.60 Very High Very High Very High
Stress 49 99.20 Very High Very High Very High
Parkinson's Disease 14 99.16 Very High Very High Very High
Pancreatic Cancer 84 91.08 High High
Neurodegenerative Disease 12 90.80 High High
Epilepsy 95 89.40 High High
Neurological Disease 10 87.28 High High
Fetal Alcohol Syndrome 20 83.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This increased pro/anti-apoptotic protein ratio triggers cytochrome C release from mitochondria, which in turn activates caspase cascade and results in apoptosis.
Positive_regulation (triggers) of Localization (release) of cytochrome C associated with apoptosis
1) Confidence 0.67 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.35 Pain Relevance 0.16
R-flurbiprofen and salicylate prevent also cytochrome c release induced by A?
Positive_regulation (induced) of Localization (release) of cytochrome c
2) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.62 Pain Relevance 0.39
In particular, mitochondrial Ca2+ overload can favor cardiolipin peroxidation, thereby affecting mitochondrial permeability transition, inducing AIF and cytochrome C release, and culminating in mitochondrial dysfunction and apoptosis [61], [62].
Positive_regulation (inducing) of Localization (release) of cytochrome C associated with parkinson's disease and apoptosis
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.45 Pain Relevance 0
Figure 2(a) illustrated that exposure of cultured hippocampal neurons to ethanol, PTZ, ethanol plus PTZ and KA caused significant increased expression of cytochrome-c in PTZ-induced seizure as compare to non PTZ treated group, suggesting that release of cytochrome-c into the cytoplasm induces the formation of apoptosome.
Positive_regulation (induces) of Localization (release) of cytochrome-c in neurons associated with convulsion
4) Confidence 0.49 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.36 Pain Relevance 0.06
Mitochondrial cytochrome-c release is a key event in the activation of caspase-3, a downstream pivotal step to initiate apoptosis [8].
Positive_regulation (activation) of Localization (release) of cytochrome-c associated with apoptosis
5) Confidence 0.49 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 1.70 Pain Relevance 0.19
Our findings indicate that primary culture from PTZ-induced seizure model triggers robust caspase-3 activation, release of cytochrome-c and decrease GABAB1R expression which has further decreasing effect on PKA expression level in hippocampal neurons of prenatal rat brain, while the co treatment of baclofen and phaclofen reverse the effects of PTZ and provide neuroprotection.
Positive_regulation (triggers) of Localization (release) of cytochrome-c in brain associated with convulsion
6) Confidence 0.49 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.70 Pain Relevance 0.03
PTZ-induced seizure enhances the release of cytochrome-c
Positive_regulation (enhances) of Localization (release) of cytochrome-c associated with convulsion
7) Confidence 0.49 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.94 Pain Relevance 0.09
In the former case, release of cytochrome-c and activation of caspase-3 might be a significant stage in the mechanism of apoptotic neurodegeneration.
Positive_regulation (activation) of Localization (release) of cytochrome-c associated with apoptosis
8) Confidence 0.49 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 1.07 Pain Relevance 0.10
oligomers-induced cytochrome c release and cell death.
Positive_regulation (induced) of Localization (release) of cytochrome c associated with death
9) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.62 Pain Relevance 0.69
We found that 1 µM R-flurbiprofen and 100 µM salicylate prevent cytochrome c release induced by A?
Positive_regulation (induced) of Localization (release) of cytochrome c
10) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.55 Pain Relevance 0.46
1–42 oligomers-induced cytochrome c release and cell death.
Positive_regulation (induced) of Localization (release) of cytochrome c associated with death
11) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.41 Pain Relevance 0
1–42 oligomers-induced cytochrome c release and cell death.
Positive_regulation (induced) of Localization (release) of cytochrome c associated with death
12) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.48 Pain Relevance 0.48
We find that FCCP at 100 nM prevents both cytochrome c release induced by both A?
Positive_regulation (induced) of Localization (release) of cytochrome c
13) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.42 Pain Relevance 0
To confirm As-induced mitochondria-dependent apoptosis, we determined the mitochondrial membrane potential, intracellular ATP level as well as expressions of Bcl-2 family and BH-3 only proteins, cytochrome c, caspase 3, caspase 9, Apaf1 and PARP in arsenic-induced hepatic pathophysiology and observed that As significantly up-regulated pro-apoptotic (Bad, Bax, Bim) and down-regulated anti-apoptotic (Bcl-2, Bcl-xL) proteins, reduced mitochondrial membrane potential and intracellular ATP level, increased cytochrome c release and protein level of Apaf-1 in the cytosol.
Positive_regulation (increased) of Localization (release) of cytochrome c associated with apoptosis
14) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.81 Pain Relevance 0

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