INT172863

Context Info Confidence 0.04 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.76 Pain Relevance 0

signal transduction (Ltb4r1) plasma membrane (Ltb4r1) signal transducer activity (Ltb4r1)

Anatomy Link Frequency platelet 2 Ltb4r1 (Mus musculus)

Pain Link Frequency Relevance Heat cINOD 18 25.52 COX-2 inhibitor 10 11.04 aspirin 8 5.00 cytokine 3 5.00 Inflammation 3 5.00 antagonist 3 5.00 Paracetamol 1 5.00 metalloproteinase 1 5.00

Disease Link Frequency Relevance Heat Leukemia 1 93.60 Colon Cancer 5 92.32 Apoptosis 39 90.60 Cancer 76 76.80 Prostate Cancer 6 69.68 Pancreatic Cancer 84 52.56 INFLAMMATION 5 24.08 Targeted Disruption 4 21.92 Adenocarcinoma 8 5.00 Metastasis 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Evidence also indicates that 15-S-HETE may have anti-tumorigenic effects by antagonizing other LOX products, such as LTB4 and 12-S-HETE [28]. 15-HETE inhibits LTB4 production and reduces LTB4 binding to its receptors and thereby blocks cellular responses to LTB4. 15-HETE also blocks platelet-type 12-LOX activity and reduces 5-LOX activity in rat basophilic leukemia cells [28,32].

Negative_regulation (reduces) of LTB4 Binding (binding) of in platelet associated with leukemia

1) Confidence 0.04 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.76 Pain Relevance 0

General Comments

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