INT172863

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Context Info
Confidence 0.04
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.76
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ltb4r1) plasma membrane (Ltb4r1) signal transducer activity (Ltb4r1)
Anatomy Link Frequency
platelet 2
Ltb4r1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 18 25.52 Quite Low
COX-2 inhibitor 10 11.04 Low Low
aspirin 8 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 1 93.60 High High
Colon Cancer 5 92.32 High High
Apoptosis 39 90.60 High High
Cancer 76 76.80 Quite High
Prostate Cancer 6 69.68 Quite High
Pancreatic Cancer 84 52.56 Quite High
INFLAMMATION 5 24.08 Low Low
Targeted Disruption 4 21.92 Low Low
Adenocarcinoma 8 5.00 Very Low Very Low Very Low
Metastasis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence also indicates that 15-S-HETE may have anti-tumorigenic effects by antagonizing other LOX products, such as LTB4 and 12-S-HETE [28]. 15-HETE inhibits LTB4 production and reduces LTB4 binding to its receptors and thereby blocks cellular responses to LTB4. 15-HETE also blocks platelet-type 12-LOX activity and reduces 5-LOX activity in rat basophilic leukemia cells [28,32].
Negative_regulation (reduces) of LTB4 Binding (binding) of in platelet associated with leukemia
1) Confidence 0.04 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.76 Pain Relevance 0

General Comments

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