INT172866

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Context Info
Confidence 0.19
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.81
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Lox) extracellular region (Lox) proteinaceous extracellular matrix (Lox)
nucleus (Lox)
Lox (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 30 99.04 Very High Very High Very High
cINOD 72 82.88 Quite High
COX-2 inhibitor 40 61.12 Quite High
Bile 1 55.80 Quite High
aspirin 32 51.32 Quite High
antagonist 12 37.76 Quite Low
cytokine 12 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 304 99.64 Very High Very High Very High
Pancreatic Cancer 336 99.60 Very High Very High Very High
INFLAMMATION 38 99.04 Very High Very High Very High
Chronic Renal Failure 10 98.28 Very High Very High Very High
Apoptosis 156 92.40 High High
Intestinal Cancer 8 89.04 High High
Carcinoma 4 84.92 Quite High
Lung Cancer 12 79.88 Quite High
Targeted Disruption 17 65.52 Quite High
Albuminuria 10 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further work is needed to target LOX enzymes chemoprevention, including the validation of these targets and the establishment of useful LOX modulators.
Regulation (target) of Gene_expression (chemoprevention) of LOX
1) Confidence 0.19 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.00 Pain Relevance 0.22
Molecular mechanisms of COX and LOX-mediated pancreatic cancer development
Regulation (Molecular) of Gene_expression (mechanisms) of LOX associated with pancreatic cancer
2) Confidence 0.17 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.28 Pain Relevance 0.05
Mitogenic effects of COX and LOX metabolites
Regulation (metabolites) of Gene_expression (effects) of LOX
3) Confidence 0.17 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.21 Pain Relevance 0.03
To further elucidate the lack of beneficial effects of sEH inhibition on the progression of chronic renal failure, we investigated the pro-inflammatory lipoxygenase system. 5/6-Nx had no significant effect on the renal expression of 5-Lox and 12-Lox, whereas a trend towards increased expression of 15-Lox was observed.
Neg (no) Regulation (effect) of Gene_expression (expression) of Lox associated with chronic renal failure and inflammation
4) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.20 Pain Relevance 0.08
We recently explored the effect of LOX inhibition on pancreatic cancer cell proliferation and survival using pharmacological LOX inhibitors and a FLAP inhibitor, as well as antisense oligonucleotides targeting 5-LOX, 12-LOX or 15-LOX expression [45,52].
Regulation (targeting) of Gene_expression (expression) of LOX associated with pancreatic cancer
5) Confidence 0.10 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.13 Pain Relevance 0.08

General Comments

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