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Context Info
Confidence 0.23
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.96
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger3)
Anatomy Link Frequency
stomach 1
theca 1
cortex 1
Ptger3 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 59 99.68 Very High Very High Very High
Inflammation 44 95.16 Very High Very High Very High
Hippocampus 17 93.52 High High
cOX1 2 93.20 High High
calcitonin gene related peptide 14 89.24 High High
Central nervous system 3 82.80 Quite High
Pain 36 82.72 Quite High
qutenza 74 71.76 Quite High
cytokine 22 71.08 Quite High
antagonist 35 65.84 Quite High
Disease Link Frequency Relevance Heat
Fever 14 98.90 Very High Very High Very High
Cv General 2 Under Development 1 98.88 Very High Very High Very High
Hemorrhage 2 98.08 Very High Very High Very High
Infection 35 96.76 Very High Very High Very High
INFLAMMATION 51 95.16 Very High Very High Very High
Cancer 78 94.00 High High
Targeted Disruption 57 93.60 High High
Nociception 16 89.44 High High
Pancreatic Cancer 84 86.08 High High
Hypothermia 19 86.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that both EP2 and EP3, but not EP1 or EP4, are involved in the LTP in the visual cortex.

Negative_regulation (involved) of EP3 in cortex associated with long-term potentiation
1) Confidence 0.23 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0.06 Pain Relevance 0.14
The TBS that induces LTP causes bidirectional trafficking of EP2 and EP3 into the membrane and the cytosol, respectively, which results in an increase in EP2 and a decrease in EP3 at the membrane.
Negative_regulation (decrease) of EP3 associated with long-term potentiation
2) Confidence 0.20 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.40
Recently, theca cells have also been suggested as a target for PGE2 action, with detection of mRNA for EP2, EP3, and EP4 in bovine theca [32] and EP2 mRNA in mouse theca cells [9].
Negative_regulation (detection) of EP3 in theca
3) Confidence 0.20 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
PGE2 receptors are a family of G-protein-coupled receptors, namely, EP1, EP2, EP3, and EP4 [68].
Negative_regulation (family) of EP3
4) Confidence 0.09 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.25 Pain Relevance 0.03
However, this effect has been attributed to a lack of PG synthesis and action on their receptors (IP, EP2 and EP3 in the duodenum and EP1 in the stomach) [12, 126, 178], which causes an increase in the acid secretion.
Negative_regulation (lack) of EP3 in stomach
5) Confidence 0.08 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.65 Pain Relevance 0.71
PGE2 produces fever when injected intracerebroventricularly [27] and mice lacking the EP3 receptor also lacked an appropriate febrile response to PGE2 [28].
Negative_regulation (lacking) of EP3 receptor associated with cv general 2 under development and fever
6) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904706 Disease Relevance 1.00 Pain Relevance 0.20

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