INT172872

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 16
Disease Relevance 12.99
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Lox) extracellular region (Lox) proteinaceous extracellular matrix (Lox)
nucleus (Lox)
Anatomy Link Frequency
endothelial cells 1
pancreas 1
endothelium 1
extracellular matrix 1
MDA-MB-231 1
Lox (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 41 99.00 Very High Very High Very High
ischemia 6 95.68 Very High Very High Very High
antagonist 17 95.60 Very High Very High Very High
COX-2 inhibitor 50 91.16 High High
Calcitonin gene-related peptide 7 89.16 High High
qutenza 2 87.04 High High
c fibre 1 86.12 High High
metalloproteinase 23 84.96 Quite High
aspirin 51 84.36 Quite High
agonist 3 80.20 Quite High
Disease Link Frequency Relevance Heat
Cancer 1176 99.56 Very High Very High Very High
Breast Cancer 66 99.48 Very High Very High Very High
Cystic Fibrosis 35 99.00 Very High Very High Very High
Fibrosis 15 99.00 Very High Very High Very High
Metastasis 461 98.88 Very High Very High Very High
Cv Unclassified Under Development 4 95.68 Very High Very High Very High
Pancreatic Cancer 420 92.88 High High
Adhesions 66 92.32 High High
Death 45 90.88 High High
Disease 35 87.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TM treatment significantly inhibited FAK activation as well as the activation of LOX.
Positive_regulation (activation) of LOX
1) Confidence 0.49 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.18 Pain Relevance 0.03
Our findings suggest that LOX activity is required during extravasation and/or initial tissue colonization by circulating MDA-MB-231 cells, lending support to the idea that LOX inhibition might be useful in metastasis prevention.



Positive_regulation (required) of LOX in MDA-MB-231 associated with metastasis
2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2680032 Disease Relevance 1.09 Pain Relevance 0.04
LOX, an extracellular matrix-remodeling enzyme, is required for the oxidative deamination of lysine residues in collagen and elastin molecules that is required for fiber cross-linking; hence, LOX controls both the structure and the tensile strength of ECM, and thus acts to preserve tissue integrity [10].
Positive_regulation (required) of LOX in extracellular matrix
3) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 0.69 Pain Relevance 0
In blood vessels LOX is expressed both the endothelium and the vascular smooth muscle cells [14], [45], [46], [47]; LOX expression is also upregulated in invasive breast cancer cells [22], [23].
Positive_regulation (upregulated) of LOX in endothelium associated with breast cancer
4) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 0.71 Pain Relevance 0
TM treatment significantly decreased tumor cell motility and invasiveness by inhibiting lysyl oxidase (LOX) activity, FAK activation and MMP2 levels.
Positive_regulation (activation) of lysyl oxidase associated with cancer
5) Confidence 0.33 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2922193 Disease Relevance 1.55 Pain Relevance 0.03
TM treatment significantly decreased tumor cell motility and invasiveness by inhibiting lysyl oxidase (LOX) activity, FAK activation and MMP2 levels.
Positive_regulation (activation) of LOX associated with cancer
6) Confidence 0.33 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2922193 Disease Relevance 1.49 Pain Relevance 0.03
Therefore, TM may be inhibiting tumor cell migration by inhibiting FAK activation via lysyl oxidase.
Positive_regulation (activation) of lysyl oxidase associated with cancer
7) Confidence 0.33 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.02 Pain Relevance 0.04
However, recent work has shown that LOX regulates a number of cellular functions including cell migration via the activation of FAK/Src pathway [41,24].
Positive_regulation (activation) of LOX
8) Confidence 0.33 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.10 Pain Relevance 0.04
In addition to catalyzing the synthesis of mutagens, both COX-2 and LOX can be induced by carcinogens, such as NNK and BOP [131-134].
Positive_regulation (induced) of LOX
9) Confidence 0.30 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.38 Pain Relevance 0.03
Indeed, the expression level of this LOX has been shown to increase in bronchial tissues of CF patients [27].
Positive_regulation (increase) of LOX associated with fibrosis
10) Confidence 0.29 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.23 Pain Relevance 0.21
One limitation of all these studies, however, is that they are predominantly performed in glomerular cells or culture and that therefore the role of LOX for tubulo-interstitial fibrosis has to remain unclear.
Positive_regulation (role) of LOX associated with fibrosis
11) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 1.12 Pain Relevance 0.18
Our unpublished data show that both 5-LOX and 12-LOX are induced in pancreatic ductal cells following treatment with BOP or NNK.
Positive_regulation (induced) of LOX
12) Confidence 0.26 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.38 Pain Relevance 0
Our unpublished data show that both 5-LOX and 12-LOX are induced in pancreatic ductal cells following treatment with BOP or NNK.
Positive_regulation (induced) of LOX
13) Confidence 0.26 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.38 Pain Relevance 0
Several excellent studies support the use of COX inhibitors for preventing cancer of different organs including colon, lung, breast and pancreas, while exploration of the potential for LOX inhibitors as chemopreventive agents is just beginning.
Positive_regulation (potential) of LOX in pancreas associated with cancer
14) Confidence 0.21 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.25 Pain Relevance 0.13
LOX activity is required for serum- and bFGF-stimulated endothelial cell proliferation and for modified low-density lipoprotein-induced monocyte binding to endothelial cells [115]. 12(S)-HETE can directly stimulate endothelial cell mitogenesis, migration and surface expression of integrin [115-118].
Positive_regulation (required) of LOX in endothelial cells
15) Confidence 0.20 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.14 Pain Relevance 0.05
Inhibition of COX leads to increased metabolism of AA via LOX and CYP pathways.
Positive_regulation (increased) of LOX
16) Confidence 0.09 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563450 Disease Relevance 0.28 Pain Relevance 0.50

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