INT172876

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Context Info
Confidence 0.03
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.66
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnfrsf10b)
Tnfrsf10b (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 17 97.24 Very High Very High Very High
cytokine 56 96.64 Very High Very High Very High
Inflammation 47 82.04 Quite High
cINOD 19 75.84 Quite High
Multiple sclerosis 48 69.16 Quite High
rheumatoid arthritis 88 68.16 Quite High
Central nervous system 2 51.36 Quite High
antagonist 8 45.60 Quite Low
Arthritis 26 15.88 Low Low
psoriasis 44 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 65 100.00 Very High Very High Very High
Death 17 100.00 Very High Very High Very High
Repression 1 99.92 Very High Very High Very High
Apoptosis 80 99.64 Very High Very High Very High
Cancer 160 93.96 High High
INFLAMMATION 50 82.04 Quite High
Glioblastoma 38 79.44 Quite High
Influenza Virus Infection 2 75.80 Quite High
Diabetes Mellitus 8 70.04 Quite High
Multiple Sclerosis 57 69.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Forced COX-2 expression significantly attenuated TRAIL-induced apoptosis and was associated with transcriptional repression of death receptor-5 and up-regulation of Bcl-2 [89].
Positive_regulation (regulation) of death receptor-5 associated with repression, apoptosis and death
1) Confidence 0.03 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.21 Pain Relevance 0.21
Among the genes upregulated in SLE were TNF/death receptor genes such as TNFRII, and the death receptor ligand TNF-related apoptosis-inducing ligand (TRAIL) (TNFSF10).
Positive_regulation (upregulated) of death receptor associated with apoptosis, systemic lupus erythematosus and death
2) Confidence 0.02 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.88 Pain Relevance 0.33
In addition, activation of death receptor-induced apoptosis-related caspase 8 protein was monitored.
Positive_regulation (activation) of death receptor associated with apoptosis and death
3) Confidence 0.01 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.58 Pain Relevance 0

General Comments

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