INT172896

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Context Info
Confidence 0.05
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.13
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Lox, Mcl1) cell differentiation (Mcl1) mitochondrion (Mcl1)
oxidoreductase activity (Lox) extracellular region (Lox) proteinaceous extracellular matrix (Lox)
Anatomy Link Frequency
cleavage 2
Lox (Mus musculus)
Mcl1 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 8 55.84 Quite High
COX-2 inhibitor 10 34.16 Quite Low
cINOD 18 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 84 98.24 Very High Very High Very High
Apoptosis 39 97.68 Very High Very High Very High
Fibrosis 1 69.92 Quite High
Insulin Resistance 1 68.64 Quite High
Cancer 76 49.60 Quite Low
Adenocarcinoma 8 5.00 Very Low Very Low Very Low
Prostate Cancer 6 5.00 Very Low Very Low Very Low
Metastasis 5 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Colon Cancer 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To confirm that apoptosis occurs in pancreatic cancer cells following LOX inhibitor treatment, we conducted further studies that showed that LOX inhibitors reduce expression of Bcl-2 and Mcl-1 and induce activation of caspase-3 and -9 as well as cleavage of the caspase-3 target, PARP [53,54].


LOX Negative_regulation (reduce) of Gene_expression (expression) of Mcl-1 in cleavage associated with pancreatic cancer and apoptosis
1) Confidence 0.05 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.13 Pain Relevance 0.03

General Comments

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