INT172899

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Context Info
Confidence 0.02
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 5.54
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2, Bcl2l1) intracellular (Bcl2, Bcl2l1) cytoplasm (Bcl2, Bcl2l1)
cell proliferation (Bcl2, Bcl2l1) cytosol (Bcl2, Bcl2l1) growth (Bcl2, Bcl2l1)
Bcl2 (Mus musculus)
Bcl2l1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 6 100.00 Very High Very High Very High
agonist 1 72.72 Quite High
withdrawal 1 71.92 Quite High
chemokine 42 50.00 Quite Low
metalloproteinase 1 42.24 Quite Low
cINOD 18 37.32 Quite Low
COX-2 inhibitor 10 12.16 Low Low
imagery 13 5.00 Very Low Very Low Very Low
aspirin 8 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 19 100.00 Very High Very High Very High
Apoptosis 158 99.98 Very High Very High Very High
Prostate Cancer 40 91.44 High High
Carcinoma 51 83.20 Quite High
Pancreatic Cancer 84 75.12 Quite High
Cancer 137 72.16 Quite High
Adhesions 73 61.76 Quite High
Colon Cancer 55 51.96 Quite High
Repression 11 17.80 Low Low
Metastasis 55 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anti-apoptotic Bcl-2 proteins such as Bcl-2, Mcl-1, and Bcl-XL heterodimerize with pro-apoptotic proteins to inhibit their function [8].
Bcl-2 Binding (heterodimerize) of Bcl-XL associated with apoptosis
1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.26 Pain Relevance 0
BAD, bcl-xl/bcl-2- antagonist causing cell death, was initially identified in a yeast two hybrid screen interacting with Bcl-2 or Bcl-xl [10].
bcl-2 Binding (interacting) of Bcl-xl associated with antagonist and death
2) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 1.69 Pain Relevance 0.12
Anti-apoptotic Bcl-2 proteins such as Bcl-2, Mcl-1, and Bcl-XL heterodimerize with pro-apoptotic proteins to inhibit their function [8].
Bcl-2 Binding (heterodimerize) of Bcl-XL associated with apoptosis
3) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.25 Pain Relevance 0
Bad is a pro-apoptotic member of the Bcl-2 family that can displace Bax from binding to Bcl-2 and Bcl-xL, resulting in cell death.
Bcl-2 Binding (binding) of Bcl-xL associated with apoptosis and death
4) Confidence 0.01 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.34 Pain Relevance 0

General Comments

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