INT17290

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Context Info
Confidence 0.68
First Reported 1982
Last Reported 2010
Negated 1
Speculated 0
Reported most in Title
Documents 11
Total Number 11
Disease Relevance 1.73
Pain Relevance 3.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt2b)
Anatomy Link Frequency
liver 6
fat 1
Ugt2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 10 100.00 Very High Very High Very High
Paracetamol 172 98.86 Very High Very High Very High
Opioid 13 98.24 Very High Very High Very High
Arthritis 7 91.12 High High
MU agonist 1 88.84 High High
antagonist 1 88.24 High High
Buprenorphine 5 87.80 High High
Bile 3 68.20 Quite High
cINOD 6 66.84 Quite High
Dopamine 1 49.28 Quite Low
Disease Link Frequency Relevance Heat
Van Bogaert's Disease 7 100.00 Very High Very High Very High
Arthritis 11 98.20 Very High Very High Very High
Toxicity 19 90.12 High High
Overdose 9 86.28 High High
Liver Failure 1 85.32 High High
INFLAMMATION 6 66.12 Quite High
Stress 2 63.12 Quite High
Hepatotoxicity 5 54.72 Quite High
Apoptosis 16 50.00 Quite Low
Drug Induced Neurotoxicity 6 43.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
UDP-glucuronosyltransferase activities toward estrone, bilirubin, 4-nitrophenol, and morphine did not co-purify with the activity toward chenodeoxycholic acid and testosterone and were not detectable in the pure enzyme in the presence or absence of phospholipids.
Neg (not) Gene_expression (detectable) of UDP-glucuronosyltransferase associated with van bogaert's disease and morphine
1) Confidence 0.68 Published 1982 Journal J. Biol. Chem. Section Abstract Doc Link 6806274 Disease Relevance 0.53 Pain Relevance 0.10
A recombinant phenobarbital-inducible rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 2B1) stably expressed in V79 cells catalyzes the glucuronidation of morphine, phenols, and carboxylic acids.
Gene_expression (expressed) of UDP-glucuronosyltransferase in liver associated with morphine
2) Confidence 0.59 Published 1994 Journal Mol. Pharmacol. Section Title Doc Link 8302279 Disease Relevance 0.07 Pain Relevance 0.25
V79 (Chinese hamster lung fibroblast) cell lines expressing a functional recombinant phenobarbital-inducible rat liver UDP-glucuronosyltransferase (UGT), i.e., UGT2B1, were established.
Gene_expression (expressing) of UDP-glucuronosyltransferase in liver
3) Confidence 0.59 Published 1994 Journal Mol. Pharmacol. Section Abstract Doc Link 8302279 Disease Relevance 0.05 Pain Relevance 0.15
A recombinant phenobarbital-inducible rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 2B1) stably expressed in V79 cells catalyzes the glucuronidation of morphine, phenols, and carboxylic acids.
Gene_expression (expressed) of UDP-glucuronosyltransferase in liver associated with morphine
4) Confidence 0.59 Published 1994 Journal Mol. Pharmacol. Section Title Doc Link 8302279 Disease Relevance 0.07 Pain Relevance 0.25
Cloning and stable expression of a cDNA encoding a rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 1.1) that catalyzes the glucuronidation of opioids and bilirubin.
Gene_expression (expression) of UDP-glucuronosyltransferase in liver associated with opioid
5) Confidence 0.58 Published 1995 Journal Mol. Pharmacol. Section Title Doc Link 7603447 Disease Relevance 0 Pain Relevance 0.25
Cloning and stable expression of a cDNA encoding a rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 1.1) that catalyzes the glucuronidation of opioids and bilirubin.
Gene_expression (expression) of UDP-glucuronosyltransferase in liver associated with opioid
6) Confidence 0.58 Published 1995 Journal Mol. Pharmacol. Section Title Doc Link 7603447 Disease Relevance 0 Pain Relevance 0.25
With respect to its influence on UDP-glucuronosyltransferase isoenzymes, PFDA may be classified as a clofibrate-type inducer.
Gene_expression (influence) of UDP-glucuronosyltransferase
7) Confidence 0.46 Published 1991 Journal Chem. Biol. Interact. Section Abstract Doc Link 1898504 Disease Relevance 0 Pain Relevance 0.08
Expression of hepatic UDP-glucuronosyltransferase 1A1 and 1A6 correlated with increased expression of the nuclear constitutive androstane receptor and peroxisome proliferator-activated receptor alpha in male rats fed a high-fat and high-sucrose diet.
Gene_expression (Expression) of UDP-glucuronosyltransferase in fat
8) Confidence 0.34 Published 2008 Journal Drug Metab. Dispos. Section Title Doc Link 17967931 Disease Relevance 0 Pain Relevance 0.16
The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1.
Gene_expression (expressed) of UDP-glucuronosyltransferase
9) Confidence 0.19 Published 1996 Journal Arch. Biochem. Biophys. Section Title Doc Link 8806713 Disease Relevance 0 Pain Relevance 0.60
Acetaminophen is mainly metabolised, in the liver, via conjugation by sulphotransferase and UDP-glucuronosyltransferase and then excreted, but a small fraction of it is metabolised by CYP2E1 [7], [35].
Gene_expression (sulphotransferase) of UDP-glucuronosyltransferase in liver associated with paracetamol
10) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.44 Pain Relevance 1.03
In addition, uridine 5'-diphosphate-glucuronosyltransferase activity toward bilirubin and p-nitrophenol, as well as levels of cytochrome P-450 and beta-glucuronidase were determined in these microsomal preparations.
Gene_expression (levels) of diphosphate-glucuronosyltransferase
11) Confidence 0.06 Published 1999 Journal Drug Metab. Dispos. Section Abstract Doc Link 9884306 Disease Relevance 0.57 Pain Relevance 0.33

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