INT172901

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.13
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 6.51
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Bad, Bcl2l1) cytosol (Bad, Bcl2l1) mitochondrion (Bad, Bcl2l1)
cytoplasm (Bad, Bcl2l1) lipid binding (Bad) growth (Bcl2l1)
Bad (Mus musculus)
Bcl2l1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 15 100.00 Very High Very High Very High
withdrawal 3 91.20 High High
agonist 3 73.20 Quite High
metalloproteinase 2 53.04 Quite High
cINOD 36 38.80 Quite Low
COX-2 inhibitor 20 22.96 Low Low
imagery 15 7.20 Low Low
addiction 3 5.52 Low Low
aspirin 16 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 159 100.00 Very High Very High Very High
Death 11 100.00 Very High Very High Very High
Prostate Cancer 114 91.92 High High
Pancreatic Cancer 168 85.92 High High
Cancer 227 74.88 Quite High
Adhesions 6 72.56 Quite High
Repression 2 19.28 Low Low
Adenocarcinoma 16 5.00 Very Low Very Low Very Low
Metastasis 10 5.00 Very Low Very Low Very Low
Colon Cancer 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, when Bcl-2 or BclXL forms a heterodimeric complex with BAD, cells can overcome the G0/G1 growth arrest and enter into S phase [17], [18].
BAD Binding (complex) of BclXL
1) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.78 Pain Relevance 0
BAD, bcl-xl/bcl-2- antagonist causing cell death, was initially identified in a yeast two hybrid screen interacting with Bcl-2 or Bcl-xl [10].
BAD Binding (interacting) of Bcl-xl associated with antagonist and death
2) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 1.70 Pain Relevance 0.12
Phosphorylated BAD fails to bind Bcl-XL or Bcl-2 proteins, and has been considered an apoptosis sentinel inactivated by anti-apoptotic signals.
BAD Binding (bind) of Bcl-XL associated with apoptosis
3) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 1.44 Pain Relevance 0.12
Bad is a pro-apoptotic member of the Bcl-2 family that can displace Bax from binding to Bcl-2 and Bcl-xL, resulting in cell death.
Bad Binding (binding) of Bcl-xL associated with apoptosis and death
4) Confidence 0.01 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.35 Pain Relevance 0
Phosphorylation of Bad results in its binding to 14-3-3 proteins and prevents it binding to Bcl-2 and Bcl-xL.
Bad Binding (binding) of Bcl-xL
5) Confidence 0.01 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.24 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox