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Context Info
Confidence 0.30
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.19
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax, Bcl2) endoplasmic reticulum (Bax, Bcl2) intracellular (Bax, Bcl2)
cytoplasm (Bax, Bcl2) cytosol (Bax, Bcl2) cell proliferation (Bax, Bcl2)
Bax (Mus musculus)
Bcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 3 68.76 Quite High
metalloproteinase 1 41.36 Quite Low
cINOD 19 36.08 Quite Low
COX-2 inhibitor 10 11.28 Low Low
aspirin 8 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 260 99.98 Very High Very High Very High
Death 36 98.76 Very High Very High Very High
Pancreatic Cancer 84 74.24 Quite High
Infection 52 72.88 Quite High
Toxicity 6 66.04 Quite High
Cancer 105 63.12 Quite High
Adhesions 3 60.88 Quite High
Breast Cancer 2 58.76 Quite High
Sarcoma 1 57.76 Quite High
Epstein-barr Virus 30 57.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Candidates for these binding partners are the BH3-only proteins, which like BIM, have been shown to have higher affinities for anti-apoptotic BCL2 family members and can only bind weakly to BAX [30].
BAX Binding (bind) of BCL2 associated with apoptosis
1) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.30 Pain Relevance 0.03
In particular, Bax can homodimerize with itself and heterodimerize with Bcl-2 or Bcl-xL.
Bax Binding (heterodimerize) of Bcl-2
2) Confidence 0.17 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2222640 Disease Relevance 0.70 Pain Relevance 0
HV68 vBcl-2 to interact with Bax and Bak, block apoptosis, and abrogate vBcl-2 function in persistent replication and reactivation from latency in vivo [25].
Bax Binding (interact) of vBcl-2 associated with apoptosis
3) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.68 Pain Relevance 0
We also investigated if BHRF1, in a manner similar to some mammalian [21], [25] and viral Bcl-2 proteins [26], [27], might directly bind Bax and Bak, the downstream mediators of mitochondrial damage.
Bax Spec (might) Binding (bind) of Bcl-2
4) Confidence 0.02 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009601 Disease Relevance 0.20 Pain Relevance 0
Bad is a pro-apoptotic member of the Bcl-2 family that can displace Bax from binding to Bcl-2 and Bcl-xL, resulting in cell death.
Bax Binding (binding) of Bcl-2 associated with apoptosis and death
5) Confidence 0.01 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.32 Pain Relevance 0

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