INT172915

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Context Info
Confidence 0.31
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 6.84
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Iapp) extracellular region (Iapp)
Anatomy Link Frequency
beta cells 2
Iapp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 6 95.44 Very High Very High Very High
Somatostatin 6 93.16 High High
abdominal pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 420 100.00 Very High Very High Very High
Insulin Resistance 42 99.12 Very High Very High Very High
Cancer 96 96.12 Very High Very High Very High
Diabetes Mellitus 216 95.52 Very High Very High Very High
Impaired Glucose Tolerance 36 95.44 Very High Very High Very High
Alzheimer's Dementia 12 78.40 Quite High
Congenital Anomalies 6 73.40 Quite High
Death 18 67.04 Quite High
Disease 24 5.00 Very Low Very Low Very Low
Hyperinsulinism 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the increased IAPP secretion found in pancreatic cancer patients is unlikely to be responsible for their peripheral insulin resistance.


Positive_regulation (responsible) of Localization (secretion) of IAPP associated with pancreatic cancer and insulin resistance
1) Confidence 0.31 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149418 Disease Relevance 1.54 Pain Relevance 0.08
Thus, the increased IAPP secretion found in pancreatic cancer patients is unlikely to be responsible for their peripheral insulin resistance.


Positive_regulation (increased) of Localization (secretion) of IAPP associated with pancreatic cancer and insulin resistance
2) Confidence 0.31 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149418 Disease Relevance 1.44 Pain Relevance 0.08
Therefore, the increased IAPP release seen in pancreatic cancer patients may be responsible, at least in part, for the islet dysfunction seen in these individuals.
Positive_regulation (increased) of Localization (release) of IAPP associated with pancreatic cancer
3) Confidence 0.31 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149418 Disease Relevance 1.00 Pain Relevance 0.09
In a similar co-culture model, Ding et al. found that culture media conditioned by human pancreatic cancer cells contained a soluble molecule that selectively enhanced IAPP release from BRIN-BD11 beta cells [28].
Positive_regulation (enhanced) of Localization (release) of IAPP in beta cells associated with pancreatic cancer
4) Confidence 0.31 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149418 Disease Relevance 0.92 Pain Relevance 0.06
In contrast, the expression of IAPP mRNA in these islets is unchanged, suggesting normal production but increased release of IAPP [25].
Positive_regulation (increased) of Localization (release) of IAPP
5) Confidence 0.27 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149418 Disease Relevance 0.97 Pain Relevance 0
In contrast, the expression of IAPP mRNA in these islets is unchanged, suggesting normal production but increased release of IAPP [25].
Positive_regulation (increased) of Localization (release) of IAPP
6) Confidence 0.19 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149418 Disease Relevance 0.97 Pain Relevance 0

General Comments

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